24906

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3165550..3166103 Replicon chromosome
Accession NC_014500
Organism Dickeya dadantii 3937

Toxin (Protein)


Gene name ccdB Uniprot ID E0SJK1
Locus tag DDA3937_RS13920 Protein ID WP_013318612.1
Coordinates 3165550..3165864 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID E0SJK2
Locus tag DDA3937_RS13925 Protein ID WP_013318613.1
Coordinates 3165867..3166103 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDA3937_RS13895 (Dda3937_04167) 3160573..3161811 + 1239 WP_033111949.1 IS110 family transposase -
DDA3937_RS22350 (Dda3937_04168) 3161932..3162798 - 867 WP_202796554.1 hypothetical protein -
DDA3937_RS23495 (Dda3937_04169) 3163024..3163671 - 648 WP_033112357.1 hypothetical protein -
DDA3937_RS13905 (Dda3937_04347) 3163984..3164427 - 444 WP_013318608.1 hypothetical protein -
DDA3937_RS13910 3164636..3165183 - 548 Protein_2791 hypothetical protein -
DDA3937_RS22355 3165419..3165553 + 135 Protein_2792 mobilization protein mobC -
DDA3937_RS13920 (Dda3937_04171) 3165550..3165864 - 315 WP_013318612.1 CcdB family protein Toxin
DDA3937_RS13925 (Dda3937_04172) 3165867..3166103 - 237 WP_013318613.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
DDA3937_RS13930 (Dda3937_04173) 3166374..3166659 + 286 Protein_2795 transposase -
DDA3937_RS13935 (Dda3937_04174) 3167522..3167932 + 411 WP_148226884.1 hypothetical protein -
DDA3937_RS13940 (Dda3937_04175) 3167995..3168390 + 396 WP_013318616.1 hypothetical protein -
DDA3937_RS13945 (Dda3937_04176) 3168404..3169720 + 1317 WP_013318617.1 hypothetical protein -
DDA3937_RS22360 (Dda3937_04177) 3169733..3170605 + 873 WP_071819884.1 deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - vgrG2 / hcp 3126494..3201103 74609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11412.32 Da        Isoelectric Point: 7.9859

>T24906 WP_013318612.1 NC_014500:c3165864-3165550 [Dickeya dadantii 3937]
MQFTVYGNTGKSAIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRPVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASPYRSQVKAAIDFLIDGI

Download         Length: 315 bp

>T24906 NC_014500:c3165864-3165550 [Dickeya dadantii 3937]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCCATTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTATCCGGCAGGCCGCCGACCGGATCGCCCTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGCATCCCTGTGCAGGCCCTGGGG
GCTGTGTTTTGTGATGCGTCGCCGTACCGTTCTCAGGTAAAGGCCGCAATAGACTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8973.99 Da        Isoelectric Point: 6.0711

>AT24906 WP_013318613.1 NC_014500:c3166103-3165867 [Dickeya dadantii 3937]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTAALDAELRHHEAKKWQEENRESIDALNRFHDEHGCFSDEYLTF

Download         Length: 237 bp

>AT24906 NC_014500:c3166103-3165867 [Dickeya dadantii 3937]
ATGACCGCGAAACAACGTAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTGCTGGTCCGTGCGCGTGAAGCGGG
GATTAACCTGAGTGCTACCCTGACAGCCGCTCTGGATGCAGAGCTTCGCCACCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAATCCATCGACGCATTAAATCGTTTTCATGATGAACACGGCTGTTTCAGCGATGAATACCTGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SJK1

Antitoxin

Source ID Structure
AlphaFold DB E0SJK2

References