24907

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3188751..3189304 Replicon chromosome
Accession NC_014500
Organism Dickeya dadantii 3937

Toxin (Protein)


Gene name ccdB Uniprot ID E0SJL3
Locus tag DDA3937_RS13965 Protein ID WP_013318624.1
Coordinates 3188751..3189065 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID E0SJL4
Locus tag DDA3937_RS13970 Protein ID WP_013318625.1
Coordinates 3189068..3189304 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDA3937_RS23525 3188191..3188484 + 294 Protein_2803 integrase -
DDA3937_RS23270 (Dda3937_01877) 3188482..3188754 + 273 Protein_2804 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
DDA3937_RS13965 (Dda3937_01876) 3188751..3189065 - 315 WP_013318624.1 CcdB family protein Toxin
DDA3937_RS13970 (Dda3937_01875) 3189068..3189304 - 237 WP_013318625.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
DDA3937_RS13975 (Dda3937_01874) 3189619..3190563 - 945 WP_033111950.1 DUF1738 domain-containing protein -
DDA3937_RS13980 (Dda3937_01873) 3191278..3192597 + 1320 Protein_2808 TerB N-terminal domain-containing protein -
DDA3937_RS22365 3192585..3193010 + 426 Protein_2809 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - vgrG2 / hcp 3126494..3201103 74609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11564.48 Da        Isoelectric Point: 7.9859

>T24907 WP_013318624.1 NC_014500:c3189065-3188751 [Dickeya dadantii 3937]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPERFVPVVRLTDGKEYAVMTHELASIPVQALG
TVFCDASQYRNQIKAAIDFLIDGI

Download         Length: 315 bp

>T24907 NC_014500:c3189065-3188751 [Dickeya dadantii 3937]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCCGTTTATCCGTTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTACTCCCTGTTGAAAAGTATCCGGCAGGCCGCCGACCGGAGCGCTTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGTATTCCTGTGCAGGCTCTGGGG
ACTGTGTTTTGTGATGCGTCGCAGTACCGTAATCAGATAAAGGCCGCAATAGACTTCCTCATCGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9017.02 Da        Isoelectric Point: 6.4792

>AT24907 WP_013318625.1 NC_014500:c3189304-3189068 [Dickeya dadantii 3937]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRHHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT24907 NC_014500:c3189304-3189068 [Dickeya dadantii 3937]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGAGCCTTACTGGTCCGGGCGCGTGAGGCGGG
TATTAACCTGAGTGCTACCCTGTCAACCGCACTGGATGCAGAGCTTCGTCACCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAGGCCATCGACGCATTAAATCGTTTTCATGATGAACACGGCTGTTTCAGTGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SJL3

Antitoxin

Source ID Structure
AlphaFold DB E0SJL4

References