Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1111411..1112078 Replicon chromosome
Accession NZ_CP107005
Organism Escherichia coli strain SY22A1

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag OFB12_RS05395 Protein ID WP_001094400.1
Coordinates 1111411..1111740 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag OFB12_RS05400 Protein ID WP_000072690.1
Coordinates 1111761..1112078 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB12_RS05390 (1106467) 1106467..1111047 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
OFB12_RS05395 (1111411) 1111411..1111740 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
OFB12_RS05400 (1111761) 1111761..1112078 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OFB12_RS05405 (1112116) 1112116..1112316 - 201 WP_001395452.1 DUF987 domain-containing protein -
OFB12_RS05410 (1112325) 1112325..1112807 - 483 WP_001407480.1 RadC family protein -
OFB12_RS05415 (1112816) 1112816..1113274 - 459 WP_000211841.1 antirestriction protein -
OFB12_RS05420 (1113377) 1113377..1113561 - 185 Protein_1058 DUF905 family protein -
OFB12_RS05425 (1114172) 1114172..1115875 - 1704 WP_000896263.1 protein YfjW -
OFB12_RS05430 (1116017) 1116017..1117026 + 1010 Protein_1060 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1101759..1133639 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T260374 WP_001094400.1 NZ_CP107005:c1111740-1111411 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT260374 WP_000072690.1 NZ_CP107005:c1112078-1111761 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References