Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 18060..18788 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP104747 | ||
| Organism | Erwinia pyrifoliae strain CP20113301 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | NYP80_RS19535 | Protein ID | WP_261648176.1 |
| Coordinates | 18474..18788 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NYP80_RS19530 | Protein ID | WP_011113999.1 |
| Coordinates | 18060..18473 (-) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NYP80_RS19515 (NYP80_19515) | 13310..14167 | - | 858 | WP_012814642.1 | LysR family transcriptional regulator | - |
| NYP80_RS19520 (NYP80_19520) | 14308..15696 | + | 1389 | WP_041473957.1 | NAD-dependent succinate-semialdehyde dehydrogenase | - |
| NYP80_RS19525 (NYP80_19525) | 15996..17552 | - | 1557 | WP_041473953.1 | methyl-accepting chemotaxis protein | - |
| NYP80_RS19530 (NYP80_19530) | 18060..18473 | - | 414 | WP_011113999.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NYP80_RS19535 (NYP80_19535) | 18474..18788 | - | 315 | WP_261648176.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NYP80_RS19540 (NYP80_19540) | 19052..19336 | - | 285 | WP_011078079.1 | VF530 family DNA-binding protein | - |
| NYP80_RS19545 (NYP80_19545) | 19496..19783 | - | 288 | WP_011078058.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| NYP80_RS19550 (NYP80_19550) | 19773..20027 | - | 255 | WP_011078059.1 | plasmid stabilization protein | - |
| NYP80_RS19555 (NYP80_19555) | 20238..21203 | - | 966 | WP_011078060.1 | ThiF family adenylyltransferase | - |
| NYP80_RS19560 (NYP80_19560) | 21219..21977 | - | 759 | WP_012814638.1 | thiazole synthase | - |
| NYP80_RS19565 (NYP80_19565) | 21981..22178 | - | 198 | WP_012814637.1 | sulfur carrier protein ThiS | - |
| NYP80_RS19570 (NYP80_19570) | 22175..23107 | - | 933 | WP_041473952.1 | FAD-dependent oxidoreductase | - |
| NYP80_RS19575 (NYP80_19575) | 23483..23644 | - | 162 | Protein_27 | Txe/YoeB family addiction module toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Non-Mobilizable plasmid | - | pla | 1..34637 | 34637 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12226.38 Da Isoelectric Point: 10.4274
>T259101 WP_261648176.1 NZ_CP104747:c18788-18474 [Erwinia pyrifoliae]
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPKALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPKALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK
Download Length: 315 bp
Antitoxin
Download Length: 138 a.a. Molecular weight: 14905.32 Da Isoelectric Point: 4.6233
>AT259101 WP_011113999.1 NZ_CP104747:c18473-18060 [Erwinia pyrifoliae]
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID
Download Length: 414 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|