257622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1108289..1108956 Replicon chromosome
Accession NZ_CP104328
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag N0499_RS05320 Protein ID WP_001094400.1
Coordinates 1108289..1108618 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag N0499_RS05325 Protein ID WP_000072690.1
Coordinates 1108639..1108956 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS05315 (1103345) 1103345..1107925 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
N0499_RS05320 (1108289) 1108289..1108618 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
N0499_RS05325 (1108639) 1108639..1108956 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N0499_RS05330 (1108994) 1108994..1109194 - 201 WP_001395452.1 DUF987 domain-containing protein -
N0499_RS05335 (1109203) 1109203..1109685 - 483 WP_001407480.1 RadC family protein -
N0499_RS05340 (1109694) 1109694..1110152 - 459 WP_000211841.1 antirestriction protein -
N0499_RS05345 (1110255) 1110255..1110478 - 224 Protein_1042 DUF905 domain-containing protein -
N0499_RS05350 (1111050) 1111050..1112753 - 1704 WP_000896263.1 protein YfjW -
N0499_RS05355 (1112895) 1112895..1113904 + 1010 Protein_1044 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1098637..1130517 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T257622 WP_001094400.1 NZ_CP104328:c1108618-1108289 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT257622 WP_000072690.1 NZ_CP104328:c1108956-1108639 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References