249137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1107843..1108510 Replicon chromosome
Accession NZ_CP099588
Organism Escherichia coli strain EMG2

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag NHF38_RS05310 Protein ID WP_001094400.1
Coordinates 1107843..1108172 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag NHF38_RS05315 Protein ID WP_000072690.1
Coordinates 1108193..1108510 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF38_RS05305 (1102899) 1102899..1107479 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
NHF38_RS05310 (1107843) 1107843..1108172 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
NHF38_RS05315 (1108193) 1108193..1108510 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NHF38_RS05320 (1108548) 1108548..1108748 - 201 WP_001395452.1 DUF987 domain-containing protein -
NHF38_RS05325 (1108757) 1108757..1109239 - 483 WP_001407480.1 RadC family protein -
NHF38_RS05330 (1109248) 1109248..1109706 - 459 WP_000211841.1 antirestriction protein -
NHF38_RS05335 (1109809) 1109809..1109993 - 185 Protein_1051 DUF905 family protein -
NHF38_RS05340 (1110604) 1110604..1112307 - 1704 WP_000896263.1 protein YfjW -
NHF38_RS05345 (1112449) 1112449..1113458 + 1010 Protein_1053 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1098191..1130071 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T249137 WP_001094400.1 NZ_CP099588:c1108172-1107843 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT249137 WP_000072690.1 NZ_CP099588:c1108510-1108193 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References