Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3628365..3628892 Replicon chromosome
Accession NC_014228
Organism Xenorhabdus nematophila ATCC 19061

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag XNC1_RS15870 Protein ID WP_041573958.1
Coordinates 3628365..3628664 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag XNC1_RS21785 Protein ID WP_193785801.1
Coordinates 3628701..3628892 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC1_RS15850 (XNC1_3766) 3624314..3625540 + 1227 WP_013185287.1 alpha-xenorhabdolysin subunit XaxA -
XNC1_RS15855 (XNC1_3767) 3625581..3626633 + 1053 WP_013185288.1 alpha-xenorhabdolysin subunit XaxB -
XNC1_RS15860 (XNC1_3768) 3626779..3627456 - 678 WP_041573746.1 hypothetical protein -
XNC1_RS15865 (XNC1_3769) 3627715..3628035 - 321 Protein_3147 transposase -
XNC1_RS15870 3628365..3628664 - 300 WP_041573958.1 CcdB family protein Toxin
XNC1_RS21785 3628701..3628892 - 192 WP_193785801.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
XNC1_RS23520 3629322..3629555 + 234 WP_038251312.1 hypothetical protein -
XNC1_RS15880 (XNC1_3773) 3629800..3630438 - 639 WP_010846277.1 TetR/AcrR family transcriptional regulator -
XNC1_RS15885 (XNC1_3774) 3630985..3632130 + 1146 WP_167335074.1 porin -
XNC1_RS15890 (XNC1_3775) 3632205..3633116 - 912 WP_010846279.1 recombination-associated protein RdgC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3627715..3628080 365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-98)

Antitoxin

Post-segregation antitoxin CcdA

(2-64)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11273.91 Da        Isoelectric Point: 7.1998

>T24804 WP_041573958.1 NC_014228:c3628664-3628365 [Xenorhabdus nematophila ATCC 19061]
FVYQYKRSGSKYSMFVDVQSDIIETLGRRIVIPLIEANHFSNKVNRQLFPVVQLRGENYRLLTTEISGVAESVIGHEIAD
VNPFSSDIKNALNILFWGV

Download         Length: 300 bp

>T24804 NC_014228:c3628664-3628365 [Xenorhabdus nematophila ATCC 19061]
TTTGTTTATCAATACAAACGTAGTGGAAGTAAATACAGCATGTTTGTCGATGTCCAGAGTGATATCATTGAAACATTAGG
AAGGCGGATCGTTATTCCTTTGATTGAAGCAAATCATTTCTCAAATAAAGTCAATCGTCAGTTATTCCCTGTAGTGCAAC
TCAGAGGTGAGAATTACCGGCTTTTAACAACTGAAATTTCAGGTGTGGCTGAAAGTGTCATAGGTCACGAAATTGCTGAT
GTAAACCCATTCTCATCAGATATTAAGAACGCGCTTAATATCTTGTTTTGGGGCGTTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7291.30 Da        Isoelectric Point: 7.2022

>AT24804 WP_193785801.1 NC_014228:c3628892-3628701 [Xenorhabdus nematophila ATCC 19061]
MKHRVNVTVDKENYLILSSAGVNISGFVNELMSKEAQRIKAENWKKDNLEGMEEVAQFIKQHGS

Download         Length: 192 bp

>AT24804 NC_014228:c3628892-3628701 [Xenorhabdus nematophila ATCC 19061]
ATGAAACATAGAGTTAATGTAACAGTTGATAAAGAGAATTATCTCATCCTGAGTTCTGCCGGGGTCAATATTTCAGGTTT
TGTTAATGAGCTCATGAGCAAGGAAGCTCAACGTATCAAAGCCGAGAATTGGAAAAAAGATAATTTGGAAGGCATGGAAG
AAGTGGCTCAATTTATCAAACAGCATGGTTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References