Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4234217..4234744 Replicon chromosome
Accession NZ_CP060401
Organism Xenorhabdus nematophila strain SII

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag H8F46_RS19070 Protein ID WP_038251308.1
Coordinates 4234436..4234744 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag H8F46_RS19065 Protein ID WP_038219275.1
Coordinates 4234217..4234435 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F46_RS19035 4229994..4230905 + 912 WP_010846279.1 recombination-associated protein RdgC -
H8F46_RS19040 4230980..4232125 - 1146 WP_162903994.1 porin -
H8F46_RS19045 4232672..4233310 + 639 WP_010846277.1 TetR/AcrR family transcriptional regulator -
H8F46_RS19050 4233555..4233788 - 234 WP_038251312.1 hypothetical protein -
H8F46_RS19055 4233787..4233888 + 102 Protein_3706 transposase -
H8F46_RS19060 4233931..4234107 - 177 WP_161783437.1 hypothetical protein -
H8F46_RS19065 4234217..4234435 + 219 WP_038219275.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
H8F46_RS19070 4234436..4234744 + 309 WP_038251308.1 CcdB family protein Toxin
H8F46_RS19075 4235029..4235394 + 366 WP_081990783.1 transposase -
H8F46_RS19080 4235653..4236330 + 678 WP_010846273.1 hypothetical protein -
H8F46_RS19085 4236476..4237528 - 1053 WP_013185288.1 alpha-xenorhabdolysin subunit XaxB -
H8F46_RS19090 4237569..4238795 - 1227 WP_041976500.1 alpha-xenorhabdolysin subunit XaxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4235029..4235394 365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11680.41 Da        Isoelectric Point: 7.1998

>T170339 WP_038251308.1 NZ_CP060401:4234436-4234744 [Xenorhabdus nematophila]
MQFFVYQYKRSGSKYSMFVDVQSDIIETLGRRIVIPLIEANHFSNKVNRQLFPVVQLRGENYRLLTTEISGVAESVIGHE
IADVNPFSSDIKNALNILFWGV

Download         Length: 309 bp

>T170339 NZ_CP077291:2261088-2261279 [Citrobacter farmeri]
GTGAAGCAGAGCGAATTCAGACGCTGGCTGGAATCTCAGGGTGTCGGGGTAACGAATGGATCGCACCATTTGAAGCTCAG
ATATCGCGGAAAACGCAGCGTCATGCCCAGACATCCAGGTGATGAGATCAAAGAGGCCTTGCGTAAAGCGATTTTAAAGC
AATTGGGTCTGTCTCCATCATCACTGATATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8325.35 Da        Isoelectric Point: 5.6805

>AT170339 WP_038219275.1 NZ_CP060401:4234217-4234435 [Xenorhabdus nematophila]
MKHRVNVTVDKENYLILSSAGVNISGFVNELMSKEAQRIKAENWKKDNLEGMEEVAQFIKQHGSFADENRDW

Download         Length: 219 bp

>AT170339 NZ_CP077291:2261308-2261724 [Citrobacter farmeri]
ATGCGCTATCCCGTTCATCTCGTTCCTGCGCCAGAAGGTGGCTATGTGGTTTCGTTTCCGGATATTCCGGAAGCGCTCAC
CCAGGGGGAGACCCGCCAGCAAGCCATTGATACCGCACTGGAAGCGTTGATCACCGCCTTTGAATTCTATTTCGAAGATA
ACCAGTCCGTCCCGTTACCTACGCCGGTGAAGGAGGGCGATGATTTTGTTGAGATCCCGCTCAGCGTTGCGTCAAAAGTT
CTTTTACTCAACGCATTCCTGGCATCAAAAATCAGCCAGCAGGAGTTAGCGAAACGCATAGGCAGACCGAAACAGGAAAT
TACCCGTCTGTTCGACTTGCGGCATGCGACAAAAATTGATGCTGTGCAGACGGCGGCGCGCGCGCTCGGCAAAGAACTGT
CGCTTACGTTGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References