Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4234174..4234701 Replicon chromosome
Accession NZ_CP032329
Organism Xenorhabdus nematophila strain YL001

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag D3790_RS19475 Protein ID WP_038251308.1
Coordinates 4234393..4234701 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag D3790_RS19470 Protein ID WP_038219275.1
Coordinates 4234174..4234392 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3790_RS19450 4229951..4230862 + 912 WP_010846279.1 recombination-associated protein RdgC -
D3790_RS19455 4230937..4232082 - 1146 WP_162903994.1 porin -
D3790_RS19460 4232629..4233267 + 639 WP_010846277.1 TetR/AcrR family transcriptional regulator -
D3790_RS20050 4233512..4233745 - 234 WP_038251312.1 hypothetical protein -
D3790_RS20055 4233888..4234064 - 177 WP_161783437.1 hypothetical protein -
D3790_RS19470 4234174..4234392 + 219 WP_038219275.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
D3790_RS19475 4234393..4234701 + 309 WP_038251308.1 CcdB family protein Toxin
D3790_RS19480 4234986..4235351 + 366 WP_081990783.1 transposase -
D3790_RS19485 4235610..4236287 + 678 WP_010846273.1 hypothetical protein -
D3790_RS19490 4236433..4237485 - 1053 WP_013185288.1 alpha-xenorhabdolysin subunit XaxB -
D3790_RS19495 4237526..4238752 - 1227 WP_041976500.1 alpha-xenorhabdolysin subunit XaxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4234986..4235351 365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11680.41 Da        Isoelectric Point: 7.1998

>T111667 WP_038251308.1 NZ_CP032329:4234393-4234701 [Xenorhabdus nematophila]
MQFFVYQYKRSGSKYSMFVDVQSDIIETLGRRIVIPLIEANHFSNKVNRQLFPVVQLRGENYRLLTTEISGVAESVIGHE
IADVNPFSSDIKNALNILFWGV

Download         Length: 309 bp

>T111667 NZ_CP032329:4234393-4234701 [Xenorhabdus nematophila]
ATGCAATTTTTTGTTTATCAATACAAACGTAGTGGAAGTAAATACAGCATGTTTGTCGATGTCCAGAGTGATATCATTGA
AACATTAGGAAGGCGGATCGTTATTCCTTTGATTGAAGCAAATCATTTCTCAAATAAAGTCAATCGTCAGTTATTCCCTG
TAGTGCAACTCAGAGGTGAGAATTACCGGCTTTTAACAACTGAAATTTCAGGTGTGGCTGAAAGTGTCATAGGTCACGAA
ATTGCTGATGTAAACCCATTCTCATCAGATATTAAGAACGCGCTTAATATCTTGTTTTGGGGCGTTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8325.35 Da        Isoelectric Point: 5.6805

>AT111667 WP_038219275.1 NZ_CP032329:4234174-4234392 [Xenorhabdus nematophila]
MKHRVNVTVDKENYLILSSAGVNISGFVNELMSKEAQRIKAENWKKDNLEGMEEVAQFIKQHGSFADENRDW

Download         Length: 219 bp

>AT111667 NZ_CP032329:4234174-4234392 [Xenorhabdus nematophila]
ATGAAACATAGAGTTAATGTAACAGTTGATAAAGAGAATTATCTCATCCTGAGTTCTGCCGGGGTCAATATTTCAGGTTT
TGTTAATGAGCTCATGAGCAAGGAAGCTCAACGTATCAAAGCCGAGAATTGGAAAAAAGATAATTTGGAAGGCATGGAAG
AAGTGGCTCAATTTATCAAACAGCATGGTTCATTTGCTGATGAAAACAGGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References