246492

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1732281..1732948 Replicon chromosome
Accession NZ_CP097884
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag NAG72_RS08255 Protein ID WP_001094400.1
Coordinates 1732281..1732610 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag NAG72_RS08260 Protein ID WP_000072690.1
Coordinates 1732631..1732948 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG72_RS08250 (1727337) 1727337..1731917 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
NAG72_RS08255 (1732281) 1732281..1732610 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
NAG72_RS08260 (1732631) 1732631..1732948 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NAG72_RS08265 (1732986) 1732986..1733186 - 201 WP_001395452.1 DUF987 domain-containing protein -
NAG72_RS08270 (1733195) 1733195..1733677 - 483 WP_001407480.1 RadC family protein -
NAG72_RS08275 (1733686) 1733686..1734144 - 459 WP_000211841.1 antirestriction protein -
NAG72_RS08280 (1734247) 1734247..1734470 - 224 Protein_1597 DUF905 domain-containing protein -
NAG72_RS08285 (1735042) 1735042..1736745 - 1704 WP_000896263.1 protein YfjW -
NAG72_RS08290 (1736887) 1736887..1737896 + 1010 Protein_1599 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1722629..1754509 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T246492 WP_001094400.1 NZ_CP097884:c1732610-1732281 [Escherichia coli str. K-12 substr. MG1655]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT246492 WP_000072690.1 NZ_CP097884:c1732948-1732631 [Escherichia coli str. K-12 substr. MG1655]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References