246413

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1105947..1106614 Replicon chromosome
Accession NZ_CP097881
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag NAG69_RS05310 Protein ID WP_001094400.1
Coordinates 1105947..1106276 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag NAG69_RS05315 Protein ID WP_000072690.1
Coordinates 1106297..1106614 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG69_RS05305 (1101003) 1101003..1105583 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
NAG69_RS05310 (1105947) 1105947..1106276 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
NAG69_RS05315 (1106297) 1106297..1106614 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NAG69_RS05320 (1106652) 1106652..1106852 - 201 WP_001395452.1 DUF987 domain-containing protein -
NAG69_RS05325 (1106861) 1106861..1107343 - 483 WP_001407480.1 RadC family protein -
NAG69_RS05330 (1107352) 1107352..1107810 - 459 WP_000211841.1 antirestriction protein -
NAG69_RS05335 (1107913) 1107913..1108097 - 185 Protein_1040 DUF905 domain-containing protein -
NAG69_RS05340 (1108708) 1108708..1110411 - 1704 WP_000896263.1 protein YfjW -
NAG69_RS05345 (1110553) 1110553..1111562 + 1010 Protein_1042 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1096295..1128175 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T246413 WP_001094400.1 NZ_CP097881:c1106276-1105947 [Escherichia coli str. K-12 substr. MG1655]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT246413 WP_000072690.1 NZ_CP097881:c1106614-1106297 [Escherichia coli str. K-12 substr. MG1655]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References