Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid pAR13438_2
Accession NZ_CP097172
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag M3M51_RS24605 Protein ID WP_001384452.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag M3M51_RS24600 Protein ID WP_000079928.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS24590 (46) 46..1077 + 1032 WP_000907874.1 plasmid replication initiator RepA -
M3M51_RS24595 (1773) 1773..1931 + 159 WP_000841008.1 hypothetical protein -
M3M51_RS24600 (1986) 1986..2255 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
M3M51_RS24605 (2255) 2255..2533 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
M3M51_RS24610 (2573) 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
M3M51_RS24615 (3538) 3538..4011 + 474 WP_001334658.1 hypothetical protein -
M3M51_RS24620 (4488) 4488..4754 - 267 Protein_6 hypothetical protein -
M3M51_RS24625 (4754) 4754..5248 - 495 WP_023278058.1 hypothetical protein -
M3M51_RS24630 (5304) 5304..5792 - 489 Protein_8 ProQ/FINO family protein -
M3M51_RS24635 (5964) 5964..7163 - 1200 WP_000948429.1 IS91 family transposase -
M3M51_RS24640 (7173) 7173..7361 - 189 WP_000957857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-33 - 1..96934 96934
flank IS/Tn blaCMY-33 - 5964..8894 2930


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T244857 WP_001384452.1 NZ_CP097172:2255-2533 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT244857 WP_000079928.1 NZ_CP097172:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References