Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 3243800..3244599 Replicon chromosome
Accession NC_013508
Organism Edwardsiella tarda EIB202

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag ETAE_RS14315 Protein ID WP_041692550.1
Coordinates 3244066..3244599 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ETAE_RS14310 Protein ID WP_041692549.1
Coordinates 3243800..3244069 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETAE_RS14285 (ETAE_3075) 3239379..3240095 + 717 WP_012849890.1 M48 family metallopeptidase -
ETAE_RS14290 (ETAE_3076) 3240340..3240807 + 468 Protein_2846 transposase -
ETAE_RS14295 (ETAE_3077) 3240893..3241690 + 798 Protein_2847 IS21 family transposase -
ETAE_RS14300 (ETAE_3078) 3241927..3242142 - 216 WP_012849893.1 Na(+)-translocating NADH-quinone reductase subunit C -
ETAE_RS14305 3242154..3242417 - 264 WP_041692548.1 DUF2442 domain-containing protein -
ETAE_RS17595 (ETAE_3079) 3242377..3242616 - 240 WP_012849894.1 DUF4160 domain-containing protein -
ETAE_RS17600 (ETAE_3080) 3243110..3243706 + 597 WP_071818540.1 helix-turn-helix domain-containing protein -
ETAE_RS14310 3243800..3244069 + 270 WP_041692549.1 DUF1778 domain-containing protein Antitoxin
ETAE_RS14315 3244066..3244599 + 534 WP_041692550.1 GNAT family N-acetyltransferase Toxin
ETAE_RS14320 (ETAE_3082) 3244697..3245440 - 744 WP_012849897.1 hypothetical protein -
ETAE_RS17815 3247438..3247689 + 252 Protein_2855 IS21 family transposase -
ETAE_RS14330 (ETAE_3084) 3247686..3248468 + 783 WP_012846920.1 IS21-like element ISSen3 family helper ATPase IstB -
ETAE_RS14335 (ETAE_3085) 3248573..3249376 + 804 WP_012849899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3201940..3257588 55648
flank IS/Tn - - 3240893..3241774 881
flank IS/Tn - - 3247689..3248468 779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19938.93 Da        Isoelectric Point: 7.0275

>T24440 WP_041692550.1 NC_013508:3244066-3244599 [Edwardsiella tarda EIB202]
MNSGTEFKELSKADHDRDSFDCGEIELNNFIKNFALKHMRVGISKTMVLPATDALPNNKHPICAFYTVAPSSITRNSLPD
DLGKKLPHYPVPVFLLAQLSVHIDNQGDGLGKITLIKALEYLWNVNYFLHAYAVVVDCLNDKAESFYRKYGFETLCSYDG
RVRLFLPMKTVAGLFSD

Download         Length: 534 bp

>T24440 NC_013508:3244066-3244599 [Edwardsiella tarda EIB202]
ATGAATAGTGGGACAGAGTTTAAGGAGCTGAGTAAAGCTGATCACGACAGAGATTCTTTCGACTGCGGCGAAATAGAGCT
AAACAATTTTATTAAAAATTTCGCGTTAAAACACATGCGAGTGGGCATCAGTAAGACAATGGTTTTACCTGCTACTGATG
CCCTACCCAATAACAAACATCCCATCTGTGCTTTCTATACCGTAGCCCCAAGTTCAATTACCCGAAACTCACTCCCGGAC
GATCTAGGGAAGAAACTACCTCACTACCCTGTTCCCGTTTTCCTGCTTGCTCAGCTATCTGTTCACATTGACAATCAGGG
GGATGGATTAGGGAAAATAACGCTAATAAAAGCATTAGAGTATCTATGGAATGTTAACTACTTCTTACACGCTTATGCTG
TGGTAGTGGATTGTTTAAATGACAAGGCGGAGAGTTTCTACCGCAAGTATGGGTTCGAGACGCTATGCTCTTATGACGGT
CGCGTGAGGCTATTTTTACCCATGAAGACGGTAGCAGGACTGTTCTCTGACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9827.37 Da        Isoelectric Point: 7.1662

>AT24440 WP_041692549.1 NC_013508:3243800-3244069 [Edwardsiella tarda EIB202]
MATARLDLRLDPEIKAKAEKASALLGLKTLTEYIVHIVDNDAKRVIAAHESMALPNDIFDQFMNACEQAKEPNSALKSAL
SFTREKGIK

Download         Length: 270 bp

>AT24440 NC_013508:3243800-3244069 [Edwardsiella tarda EIB202]
ATGGCTACAGCTCGCTTAGACCTGCGGTTAGACCCAGAAATCAAAGCGAAAGCAGAGAAAGCATCCGCTCTGCTCGGTTT
AAAAACTCTAACGGAATATATCGTTCATATTGTTGATAATGATGCAAAGAGAGTAATCGCTGCGCATGAAAGCATGGCTC
TACCAAACGACATTTTTGACCAATTTATGAATGCTTGTGAGCAGGCAAAAGAGCCGAATTCTGCCCTGAAATCAGCCCTA
TCATTTACTCGTGAAAAGGGCATTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References