285378

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2628417..2630137 Replicon chromosome
Accession NZ_LC127084
Organism Edwardsiella tarda strain ET-1

Toxin (Protein)


Gene name pmenT Uniprot ID D0ZER0
Locus tag SAMD00131843_RS12065 Protein ID WP_012849887.1
Coordinates 2628417..2629073 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag SAMD00131843_RS12070 Protein ID WP_012849888.1
Coordinates 2629070..2630137 (+) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMD00131843_RS12045 2623781..2624020 + 240 WP_012849883.1 hypothetical protein -
SAMD00131843_RS12050 2624059..2626497 + 2439 WP_012849884.1 type I restriction-modification system subunit M -
SAMD00131843_RS12055 2626509..2627834 + 1326 WP_012849885.1 restriction endonuclease subunit S -
SAMD00131843_RS12060 2627839..2628414 + 576 WP_012849886.1 DUF4433 domain-containing protein -
SAMD00131843_RS12065 2628417..2629073 + 657 WP_012849887.1 DUF4433 domain-containing protein Toxin
SAMD00131843_RS12070 2629070..2630137 + 1068 WP_012849888.1 macro domain-containing protein Antitoxin
SAMD00131843_RS12075 2630301..2633396 + 3096 WP_012849889.1 HsdR family type I site-specific deoxyribonuclease -
SAMD00131843_RS12080 2633396..2634112 + 717 WP_012849890.1 M48 family metallopeptidase -
SAMD00131843_RS12085 2634357..2634824 + 468 Protein_2321 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2595957..2651606 55649
flank IS/Tn - - 2634910..2635791 881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25146.59 Da        Isoelectric Point: 6.7624

>T285378 WP_012849887.1 NZ_LC127084:2628417-2629073 [Edwardsiella tarda]
VAYDYSANLNPEKALIWRIVHRDNIPWILDHGLHCGNSPVQAANWINIGNPELIGKRAGHPVPVGMGGTLHDYVPFYFTP
FSPMLMNIHSGRGGITQRPNEEIVILVSNLRNVAAQNIPFVFTDSHAYYNWVNYYTRLDDLNQIDWSILQARDFRRDPDD
PAKFERYQAEALIWQHCPITLLVGMICYNDGVRLQLEQWLSQRNLTMPVHARAGWYFS

Download         Length: 657 bp

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40713.02 Da        Isoelectric Point: 6.9067

>AT285378 WP_012849888.1 NZ_LC127084:2629070-2630137 [Edwardsiella tarda]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKAYAHACKQKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMAWIEDGLQDLRRFLIEKKVRSIAIPPLGAGNGGLNWPDVRARIESTLGDLQDTEILIYEPTEKYQNVAKSS
GVKKLTPARAMIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHINLWLNSEAKAWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGQCQPTLDSVKEG
LHQWPAGEPWASRKIKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0ZER0

Antitoxin

Source ID Structure

References