Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3234400..3236120 Replicon chromosome
Accession NC_013508
Organism Edwardsiella tarda EIB202

Toxin (Protein)


Gene name pmenT Uniprot ID D0ZER0
Locus tag ETAE_RS14270 Protein ID WP_012849887.1
Coordinates 3234400..3235056 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag ETAE_RS14275 Protein ID WP_012849888.1
Coordinates 3235053..3236120 (+) Length 356 a.a.

Genomic Context

ETAE_RS14255ETAE_RS14260ETAE_RS14265ETAE_RS17590ETAE_RS14270ETAE_RS14275ETAE_RS14280ETAE_RS14285ETAE_RS14290
Location: 3229764..3230003 (240 bp)
Type: Others
Protein ID: WP_012849883.1
Location: 3230042..3232480 (2439 bp)
Type: Others
Protein ID: WP_012849884.1
Location: 3232492..3233817 (1326 bp)
Type: Others
Protein ID: WP_012849885.1
Location: 3233822..3234397 (576 bp)
Type: Others
Protein ID: WP_012849886.1
Location: 3234400..3235056 (657 bp)
Type: Toxin
Protein ID: WP_012849887.1
Location: 3235053..3236120 (1068 bp)
Type: Antitoxin
Protein ID: WP_012849888.1
Location: 3236284..3239379 (3096 bp)
Type: Others
Protein ID: WP_012849889.1
Location: 3239379..3240095 (717 bp)
Type: Others
Protein ID: WP_012849890.1
Location: 3240340..3240807 (468 bp)
Type: Others
Protein ID: Protein_2846
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ETAE_RS14255 (ETAE_3068)3229764..3230003+240WP_012849883.1hypothetical protein-
ETAE_RS14260 (ETAE_3069)3230042..3232480+2439WP_012849884.1type I restriction-modification system subunit M-
ETAE_RS14265 (ETAE_3070)3232492..3233817+1326WP_012849885.1restriction endonuclease subunit S-
ETAE_RS17590 (ETAE_3071)3233822..3234397+576WP_012849886.1DUF4433 domain-containing protein-
ETAE_RS14270 (ETAE_3072)3234400..3235056+657WP_012849887.1DUF4433 domain-containing proteinToxin
ETAE_RS14275 (ETAE_3073)3235053..3236120+1068WP_012849888.1macro domain-containing proteinAntitoxin
ETAE_RS14280 (ETAE_3074)3236284..3239379+3096WP_012849889.1HsdR family type I site-specific deoxyribonuclease-
ETAE_RS14285 (ETAE_3075)3239379..3240095+717WP_012849890.1M48 family metallopeptidase-
ETAE_RS14290 (ETAE_3076)3240340..3240807+468Protein_2846transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--3201940..325758855648
flankIS/Tn--3240893..3241774881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25146.59 Da        Isoelectric Point: 6.7624

>T24439 WP_012849887.1 NC_013508:3234400-3235056 [Edwardsiella tarda EIB202]
VAYDYSANLNPEKALIWRIVHRDNIPWILDHGLHCGNSPVQAANWINIGNPELIGKRAGHPVPVGMGGTLHDYVPFYFTP
FSPMLMNIHSGRGGITQRPNEEIVILVSNLRNVAAQNIPFVFTDSHAYYNWVNYYTRLDDLNQIDWSILQARDFRRDPDD
PAKFERYQAEALIWQHCPITLLVGMICYNDGVRLQLEQWLSQRNLTMPVHARAGWYFS

Download         Length: 657 bp

>T24439 NC_013508:3234400-3235056 [Edwardsiella tarda EIB202]
GTGGCCTACGACTACAGCGCCAACCTCAACCCGGAAAAAGCCCTGATTTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACCACGGTCTGCACTGCGGCAACAGCCCGGTGCAGGCGGCAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGTATGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAATGAGGAAATCGTCATTCTGGT
CAGCAACCTGCGAAACGTGGCGGCGCAGAACATCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAACTGGGTCAACT
ACTACACCCGTCTGGACGATCTGAACCAGATCGACTGGTCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCAGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40713.02 Da        Isoelectric Point: 6.9067

>AT24439 WP_012849888.1 NC_013508:3235053-3236120 [Edwardsiella tarda EIB202]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKAYAHACKQKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMAWIEDGLQDLRRFLIEKKVRSIAIPPLGAGNGGLNWPDVRARIESTLGDLQDTEILIYEPTEKYQNVAKSS
GVKKLTPARAMIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHINLWLNSEAKAWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGQCQPTLDSVKEG
LHQWPAGEPWASRKIKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT24439 NC_013508:3235053-3236120 [Edwardsiella tarda EIB202]
ATGATCACATATACACAAGGCAATTTACTGGACGCGCCTGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCCCGACAATATGAAAGCCTATGCCCACGCCTGCAAACAAAAGC
AGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCGAGCTGATGGGGCCACGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGCGTGGATCGAAGACGGTTTGCAGGACTTGCGCCGCTTTTTGATCGAAAAGAA
AGTGCGGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCGGACGTCCGGGCGCGGATTGAAT
CTACGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAGAATGTCGCCAAGAGCAGC
GGTGTAAAAAAGCTCACGCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGTATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGCTACAACGCGCCATTGAACAGCACCAGCAGGAGGACGTGTTAAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACCTGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGTATCCCGGACAGCCAGCCACTGGATGTGATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTATG
GCTGAACAGCGAAGCCAAAGCGTGGTTGCCAGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTG
GTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCCGGGGACAATGCCAGCCGACGCTGGACTCGGTGAAAGAGGGG
TTGCATCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGTAAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCAT
TAACCGCGTGATGGAGTTTCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD0ZER0

Antitoxin

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Source
ID
Structure
No matching records found

References