Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 2637817..2638616 Replicon chromosome
Accession NZ_LC127084
Organism Edwardsiella tarda strain ET-1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag SAMD00131843_RS12120 Protein ID WP_041692550.1
Coordinates 2638083..2638616 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag SAMD00131843_RS12115 Protein ID WP_041692549.1
Coordinates 2637817..2638086 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMD00131843_RS12080 2633396..2634112 + 717 WP_012849890.1 M48 family metallopeptidase -
SAMD00131843_RS12085 2634357..2634824 + 468 Protein_2321 transposase -
SAMD00131843_RS12090 2634910..2635707 + 798 Protein_2322 IS21 family transposase -
SAMD00131843_RS12095 2635944..2636159 - 216 WP_012849893.1 Na(+)-translocating NADH-quinone reductase subunit C -
SAMD00131843_RS12100 2636171..2636434 - 264 WP_041692548.1 DUF2442 domain-containing protein -
SAMD00131843_RS12105 2636394..2636633 - 240 WP_012849894.1 DUF4160 domain-containing protein -
SAMD00131843_RS12110 2637127..2637723 + 597 WP_071818540.1 helix-turn-helix domain-containing protein -
SAMD00131843_RS12115 2637817..2638086 + 270 WP_041692549.1 DUF1778 domain-containing protein Antitoxin
SAMD00131843_RS12120 2638083..2638616 + 534 WP_041692550.1 GNAT family N-acetyltransferase Toxin
SAMD00131843_RS12125 2638714..2639457 - 744 WP_012849897.1 hypothetical protein -
SAMD00131843_RS12130 2641455..2641706 + 252 Protein_2330 IS21 family transposase -
SAMD00131843_RS12135 2641703..2642485 + 783 WP_012846920.1 IS21-like element ISSen3 family helper ATPase IstB -
SAMD00131843_RS12140 2642590..2643393 + 804 WP_012849899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2595957..2651606 55649
flank IS/Tn - - 2634910..2635791 881
flank IS/Tn - - 2641706..2642485 779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19938.93 Da        Isoelectric Point: 7.0275

>T285379 WP_041692550.1 NZ_LC127084:2638083-2638616 [Edwardsiella tarda]
MNSGTEFKELSKADHDRDSFDCGEIELNNFIKNFALKHMRVGISKTMVLPATDALPNNKHPICAFYTVAPSSITRNSLPD
DLGKKLPHYPVPVFLLAQLSVHIDNQGDGLGKITLIKALEYLWNVNYFLHAYAVVVDCLNDKAESFYRKYGFETLCSYDG
RVRLFLPMKTVAGLFSD

Download         Length: 534 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9827.37 Da        Isoelectric Point: 7.1662

>AT285379 WP_041692549.1 NZ_LC127084:2637817-2638086 [Edwardsiella tarda]
MATARLDLRLDPEIKAKAEKASALLGLKTLTEYIVHIVDNDAKRVIAAHESMALPNDIFDQFMNACEQAKEPNSALKSAL
SFTREKGIK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References