Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 17633..18361 Replicon plasmid pEP36
Accession NC_013263
Organism Erwinia pyrifoliae Ep1/96

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EPC_RS00135 Protein ID WP_041473956.1
Coordinates 17633..17947 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EPC_RS00140 Protein ID WP_011113999.1
Coordinates 17948..18361 (+) Length 138 a.a.

Genomic Context

EPC_RS18745EPC_RS00100EPC_RS00105EPC_RS00110EPC_RS00115EPC_RS00120EPC_RS00125EPC_RS00130EPC_RS00135EPC_RS00140EPC_RS00145EPC_RS00155EPC_RS00150
Location: 12747..12938 (192 bp)
Type: Others
Protein ID: Protein_10
Location: 13314..14246 (933 bp)
Type: Others
Protein ID: WP_041473952.1
Location: 14243..14440 (198 bp)
Type: Others
Protein ID: WP_012814637.1
Location: 14444..15202 (759 bp)
Type: Others
Protein ID: WP_012814638.1
Location: 15218..16183 (966 bp)
Type: Others
Protein ID: WP_011078060.1
Location: 16394..16648 (255 bp)
Type: Others
Protein ID: WP_011078059.1
Location: 16638..16925 (288 bp)
Type: Others
Protein ID: WP_011078058.1
Location: 17085..17369 (285 bp)
Type: Others
Protein ID: WP_011078079.1
Location: 17633..17947 (315 bp)
Type: Toxin
Protein ID: WP_041473956.1
Location: 17948..18361 (414 bp)
Type: Antitoxin
Protein ID: WP_011113999.1
Location: 18869..20425 (1557 bp)
Type: Others
Protein ID: WP_041473953.1
Location: 22254..23111 (858 bp)
Type: Others
Protein ID: WP_012814642.1
Location: 20725..22113 (1389 bp)
Type: Others
Protein ID: WP_041473957.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EPC_RS1874512747..12938+192Protein_10Txe/YoeB family addiction module toxin-
EPC_RS0010013314..14246+933WP_041473952.1FAD-dependent oxidoreductase-
EPC_RS0010514243..14440+198WP_012814637.1sulfur carrier protein ThiS-
EPC_RS0011014444..15202+759WP_012814638.1thiazole synthase-
EPC_RS0011515218..16183+966WP_011078060.1ThiF family adenylyltransferase-
EPC_RS0012016394..16648+255WP_011078059.1plasmid stabilization protein-
EPC_RS0012516638..16925+288WP_011078058.1type II toxin-antitoxin system RelE/ParE family toxin-
EPC_RS0013017085..17369+285WP_011078079.1VF530 family protein-
EPC_RS0013517633..17947+315WP_041473956.1type II toxin-antitoxin system HigB family toxinToxin
EPC_RS0014017948..18361+414WP_011113999.1helix-turn-helix domain-containing proteinAntitoxin
EPC_RS0014518869..20425+1557WP_041473953.1MCP four helix bundle domain-containing protein-
EPC_RS0015020725..22113-1389WP_041473957.1NAD-dependent succinate-semialdehyde dehydrogenase-
EPC_RS0015522254..23111+858WP_012814642.1LysR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmid-pla1..3590935909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12227.32 Da        Isoelectric Point: 10.2275

>T24261 WP_041473956.1 NC_013263:17633-17947 [Erwinia pyrifoliae Ep1/96]
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPEALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK

Download         Length: 315 bp

>T24261 NC_013263:17633-17947 [Erwinia pyrifoliae Ep1/96]
ATGCACTTGATAAGCCGTAGCATGATTAAGGATGCCACTGATAAGTACCCGCAGCATTCCAGGGAACTCCTGGCTCTGAT
GATCGCTATTGAAAAAGGGTACTTTAAGGCTCCCGAAGCGTTAAAGGCGGCGTTTCCATCACTGGACAATCTGAAATATT
TAGATAAGCACTACGTTATCAATATTGGCCGCAATGACTTGCGTTTAGTTGCGCTGGTATTTTTTGAGTCTCAAAAATTT
TATGTAAGACATGTGTTTACCCACAAAGAGTACGACGTATTTACAGCGTTACATCGCACAAAGGGGAAAAAATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14905.32 Da        Isoelectric Point: 4.6233

>AT24261 WP_011113999.1 NC_013263:17948-18361 [Erwinia pyrifoliae Ep1/96]
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID

Download         Length: 414 bp

>AT24261 NC_013263:17948-18361 [Erwinia pyrifoliae Ep1/96]
ATGCTCGTAGCCGACATCATCAAAGCCGGAGAGGCTTTAACCGCCGTTGCCCCTTTCCTTGCGGGTATTACTGACAAACG
GCAACATGCAGAGGCGCTGGAATTTGTGGAGCACCTTTTACTTAACGACCCGGAAAACCCACTTTTAGATCTGGTTTGTG
CCAAAATCACGGCTTACGAAGACACAGCGCCCGAATTCGCAGAATTTAATGCACAGCTGGCAGCCATGCCGGCAGGCGTT
GCTATGATCCGTTTGCTGCTCGATCAGCACGATTTAACGTTATCCGATTTACCCGAAATCGGTAGCAAATCGATGGTTTC
CCGCGTACTCAATGGCGAGCGTAAACTGACCCTGGAACATGCCAAAAAGTTAGCAACGCGGTTTGCCATATCTCCGGCGT
TGTTCATCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References