Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1929188..1929816 Replicon chromosome
Accession NC_010278
Organism Actinobacillus pleuropneumoniae serovar 3 str. JL03

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag APJL_RS08910 Protein ID WP_012263372.1
Coordinates 1929418..1929816 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BSF9
Locus tag APJL_RS08905 Protein ID WP_005616131.1
Coordinates 1929188..1929418 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APJL_RS08895 (APJL_1764) 1926587..1928002 + 1416 WP_005605761.1 AAA family ATPase -
APJL_RS08900 (APJL_1765) 1927995..1928567 + 573 WP_012263371.1 hypothetical protein -
APJL_RS10920 1928940..1929080 - 141 WP_005602535.1 hypothetical protein -
APJL_RS08905 (APJL_1766) 1929188..1929418 + 231 WP_005616131.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
APJL_RS08910 (APJL_1767) 1929418..1929816 + 399 WP_012263372.1 tRNA(fMet)-specific endonuclease VapC Toxin
APJL_RS08915 (APJL_1768) 1929952..1930368 - 417 WP_012263373.1 DUF417 family protein -
APJL_RS08920 (APJL_1769) 1930614..1931264 + 651 WP_012263374.1 DUF2202 domain-containing protein -
APJL_RS08925 (APJL_1770) 1931337..1931996 - 660 WP_005605767.1 hypothetical protein -
APJL_RS08930 (APJL_1771) 1932310..1933632 - 1323 WP_012263375.1 HslU--HslV peptidase ATPase subunit -
APJL_RS08935 (APJL_1772) 1933898..1934419 - 522 WP_005618211.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1913969..1931996 18027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15077.34 Da        Isoelectric Point: 7.4195

>T22622 WP_012263372.1 NC_010278:1929418-1929816 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MLTYMLDTNIAIYVVKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Download         Length: 399 bp

>T22622 NC_010278:1929418-1929816 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGCTAACTTATATGCTTGATACTAACATTGCGATTTATGTGGTTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCAGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCAAGGTAAGATCATTGGCGAGAACGATATTCATATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8595.68 Da        Isoelectric Point: 4.5358

>AT22622 WP_005616131.1 NC_010278:1929188-1929418 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREEL

Download         Length: 231 bp

>AT22622 NC_010278:1929188-1929418 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGGAAGCATCAGTATTTATGACAAATCGCAGTCAAGCGGTACGATTGCCGGCAGAAGTACGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGTAATGAACGTATTTTGGCACCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGAACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B0BSF9

References