Detailed information of TA system TA022622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1929188..1929816
• Replicon: chromosome
• Accession: NC_010278
• Organism: Actinobacillus pleuropneumoniae serovar 3 str. JL03

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: APJL_RS08910
• Protein ID: WP_012263372.1
• Coordinates: 1929418..1929816 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BSF9
• Locus tag: APJL_RS08905
• Protein ID: WP_005616131.1
• Coordinates: 1929188..1929418 (+)
• Length: 77 a.a.

Genomic Context

Location: 1926587..1928002 (1416 bp)
Type: Others
Protein ID: WP_005605761.1

Location: 1927995..1928567 (573 bp)
Type: Others
Protein ID: WP_012263371.1

Location: 1929188..1929418 (231 bp)
Type: Antitoxin
Protein ID: WP_005616131.1

Location: 1929418..1929816 (399 bp)
Type: Toxin
Protein ID: WP_012263372.1

Location: 1930614..1931264 (651 bp)
Type: Others
Protein ID: WP_012263374.1

Location: 1928940..1929080 (141 bp)
Type: Others
Protein ID: WP_005602535.1

Location: 1929952..1930368 (417 bp)
Type: Others
Protein ID: WP_012263373.1

Location: 1931337..1931996 (660 bp)
Type: Others
Protein ID: WP_005605767.1

Location: 1932310..1933632 (1323 bp)
Type: Others
Protein ID: WP_012263375.1

Location: 1933898..1934419 (522 bp)
Type: Others
Protein ID: WP_005618211.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APJL_RS08895 (APJL_1764)	1926587..1928002	+	1416	WP_005605761.1	AAA family ATPase	-
APJL_RS08900 (APJL_1765)	1927995..1928567	+	573	WP_012263371.1	hypothetical protein	-
APJL_RS10920	1928940..1929080	-	141	WP_005602535.1	hypothetical protein	-
APJL_RS08905 (APJL_1766)	1929188..1929418	+	231	WP_005616131.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
APJL_RS08910 (APJL_1767)	1929418..1929816	+	399	WP_012263372.1	tRNA(fMet)-specific endonuclease VapC	Toxin
APJL_RS08915 (APJL_1768)	1929952..1930368	-	417	WP_012263373.1	DUF417 family protein	-
APJL_RS08920 (APJL_1769)	1930614..1931264	+	651	WP_012263374.1	DUF2202 domain-containing protein	-
APJL_RS08925 (APJL_1770)	1931337..1931996	-	660	WP_005605767.1	hypothetical protein	-
APJL_RS08930 (APJL_1771)	1932310..1933632	-	1323	WP_012263375.1	HslU--HslV peptidase ATPase subunit	-
APJL_RS08935 (APJL_1772)	1933898..1934419	-	522	WP_005618211.1	ATP-dependent protease subunit HslV	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP031854 Actinobacillus pleuropneumoniae strain ORG1224 Genomic island TA110379 1917281..1935308 0 View NZ_CP031859 Actinobacillus pleuropneumoniae strain HS143 Genomic island TA110403 1917117..1934880 0.001 View NZ_CP031874 Actinobacillus pleuropneumoniae strain S1421 Genomic island TA110460 1907375..1925402 0 View NZ_CP071698 Actinobacillus pleuropneumoniae strain SC1810 Genomic island TA196745 1994992..2013020 0	inside	Genomic island	-	-	1913969..1931996	18027

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15077.34 Da
• Isoelectric Point: 7.4195

>T22622 WP_012263372.1 NC_010278:1929418-1929816 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MLTYMLDTNIAIYVVKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Nucleotide

• Length: 399 bp

>T22622 NC_010278:1929418-1929816 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGCTAACTTATATGCTTGATACTAACATTGCGATTTATGTGGTTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCAGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCAAGGTAAGATCATTGGCGAGAACGATATTCATATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8595.68 Da
• Isoelectric Point: 4.5358

>AT22622 WP_005616131.1 NC_010278:1929188-1929418 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREEL

Nucleotide

• Length: 231 bp

>AT22622 NC_010278:1929188-1929418 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGGAAGCATCAGTATTTATGACAAATCGCAGTCAAGCGGTACGATTGCCGGCAGAAGTACGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGTAATGAACGTATTTTGGCACCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGAACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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Source	ID	Structure
No matching records found

Antitoxin

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• AlphaFold DB: B0BSF9