Detailed information of TA system TA110403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1932072..1932700
• Replicon: chromosome
• Accession: NZ_CP031859
• Organism: Actinobacillus pleuropneumoniae strain HS143

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1108_RS08905
• Protein ID: WP_012263372.1
• Coordinates: 1932302..1932700 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BSF9
• Locus tag: D1108_RS08900
• Protein ID: WP_005616131.1
• Coordinates: 1932072..1932302 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1108_RS08885 (D1108_08940)	1929471..1930886	+	1416	WP_005605761.1	AAA family ATPase	-
D1108_RS08890 (D1108_08945)	1930879..1931451	+	573	WP_005620147.1	hypothetical protein	-
D1108_RS08895	1931824..1931964	-	141	WP_005602535.1	hypothetical protein	-
D1108_RS08900 (D1108_08955)	1932072..1932302	+	231	WP_005616131.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D1108_RS08905 (D1108_08960)	1932302..1932700	+	399	WP_012263372.1	tRNA(fMet)-specific endonuclease VapC	Toxin
D1108_RS08910 (D1108_08965)	1932836..1933252	-	417	WP_012263373.1	DUF417 family protein	-
D1108_RS08915 (D1108_08970)	1933498..1934148	+	651	WP_012263374.1	DUF2202 domain-containing protein	-
D1108_RS08920 (D1108_08975)	1934221..1934880	-	660	WP_005605767.1	hypothetical protein	-
D1108_RS08925 (D1108_08980)	1935194..1936516	-	1323	WP_012263375.1	HslU--HslV peptidase ATPase subunit	-
D1108_RS08930 (D1108_08985)	1936662..1937183	-	522	WP_005613306.1	ATP-dependent protease subunit HslV	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_010278 Actinobacillus pleuropneumoniae serovar 3 str. JL03 Genomic island TA004922, TA022622 1913969..1931996 0.001	inside	Genomic island	-	-	1917117..1934880	17763

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15077.34 Da
• Isoelectric Point: 7.4195

>T110403 WP_012263372.1 NZ_CP031859:1932302-1932700 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVVKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Nucleotide

• Length: 399 bp

>T110403 NZ_CP031859:1932302-1932700 [Actinobacillus pleuropneumoniae]
ATGCTAACTTATATGCTTGATACTAACATTGCGATTTATGTGGTTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCAGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCAAGGTAAGATCATTGGCGAGAACGATATTCATATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8595.68 Da
• Isoelectric Point: 4.5358

>AT110403 WP_005616131.1 NZ_CP031859:1932072-1932302 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREEL

Nucleotide

• Length: 231 bp

>AT110403 NZ_CP031859:1932072-1932302 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCAGTATTTATGACAAATCGCAGTCAAGCGGTACGATTGCCGGCAGAAGTACGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGTAATGAACGTATTTTGGCACCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGAACTATAA

Structures

Antitoxin

• AlphaFold DB: B0BSF9