21258

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 2358772..2359213 Replicon chromosome
Accession NC_007435
Organism Burkholderia pseudomallei 1710b

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag BURPS1710B_RS31285 Protein ID WP_009939402.1
Coordinates 2359040..2359213 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag BURPS1710B_RS27875 Protein ID WP_004525420.1
Coordinates 2358772..2359056 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURPS1710B_RS27850 2355094..2355414 + 321 WP_004196029.1 DUF4212 domain-containing protein -
BURPS1710B_RS27855 2355408..2357423 + 2016 WP_004529901.1 cation acetate symporter -
BURPS1710B_RS27865 2357719..2358126 - 408 Protein_1881 DDE-type integrase/transposase/recombinase -
BURPS1710B_RS27875 2358772..2359056 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
BURPS1710B_RS31285 2359040..2359213 - 174 WP_009939402.1 BrnT family toxin Toxin
BURPS1710B_RS27880 2359881..2360156 + 276 WP_004526640.1 hypothetical protein -
BURPS1710B_RS40990 2360436..2360612 + 177 WP_004552958.1 hypothetical protein -
BURPS1710B_RS27890 2360641..2360988 + 348 WP_009946438.1 hypothetical protein -
BURPS1710B_RS40995 2361036..2361254 + 219 WP_004549687.1 hypothetical protein -
BURPS1710B_RS27900 2361429..2362019 - 591 WP_038724155.1 hypothetical protein -
BURPS1710B_RS27905 2362269..2362418 + 150 WP_004537646.1 bacteriophage protein Gp44 -
BURPS1710B_RS27910 2362415..2363188 + 774 Protein_1890 prohibitin family protein -
BURPS1710B_RS41000 2363186..2363590 + 405 Protein_1891 DDE-type integrase/transposase/recombinase -
BURPS1710B_RS38140 2363553..2363981 + 429 Protein_1892 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2355408..2366050 10642
flank IS/Tn - - 2357719..2358039 320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(4-49)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6691.59 Da        Isoelectric Point: 7.9950

>T21258 WP_009939402.1 NC_007435:c2359213-2359040 [Burkholderia pseudomallei 1710b]
MSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREVKSYVEQA

Download         Length: 174 bp

>T21258 NC_007435:c2359213-2359040 [Burkholderia pseudomallei 1710b]
TTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCGGCGATCGCCTCTATTG
CGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGGGAGGTCAAGAGCTATG
TCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT21258 WP_004525420.1 NC_007435:c2359056-2358772 [Burkholderia pseudomallei 1710b]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT21258 NC_007435:c2359056-2358772 [Burkholderia pseudomallei 1710b]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGCCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACCGTGCGTTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References