211506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 63841..64388 Replicon plasmid pSJC33-3
Accession NZ_CP080258
Organism Escherichia coli strain SJC33

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag KZ313_RS24710 Protein ID WP_001384452.1
Coordinates 64110..64388 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag KZ313_RS24705 Protein ID WP_000079928.1
Coordinates 63841..64110 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ313_RS24680 (59485) 59485..60018 - 534 WP_001303319.1 transcription termination/antitermination NusG family protein -
KZ313_RS24685 (60460) 60460..60747 - 288 WP_000074849.1 conjugal transfer protein TraA -
KZ313_RS24690 (60665) 60665..60943 - 279 WP_219065241.1 ash family protein -
KZ313_RS24695 (61901) 61901..62932 + 1032 WP_000907874.1 plasmid replication initiator RepA -
KZ313_RS24700 (63628) 63628..63786 + 159 WP_000841008.1 hypothetical protein -
KZ313_RS24705 (63841) 63841..64110 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
KZ313_RS24710 (64110) 64110..64388 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
KZ313_RS24715 (64428) 64428..65276 + 849 WP_001057996.1 3'-5' exonuclease -
KZ313_RS24720 (65393) 65393..65866 + 474 WP_001334658.1 hypothetical protein -
KZ313_RS25570 (67896) 67896..68162 - 267 Protein_75 hypothetical protein -
KZ313_RS24735 (68162) 68162..68656 - 495 WP_023278058.1 hypothetical protein -
KZ313_RS24740 (68712) 68712..69314 - 603 WP_000517689.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-2 - 1..98807 98807


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T211506 WP_001384452.1 NZ_CP080258:64110-64388 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T211506 NZ_CP104890:2321-2569 [Bartonella sp. HY761]
ATGAATGTAATTTCTTATTCCAATGCTCGAGCGCAATTAAAAGACGTTATGGACAGCGCAATCCATGATAAACAAGAAGT
TGTCGTATCGCGAAAAAACGGTGAAGCTGTCGTTGTTATATCATTAGAGACATGGAACTCTATTAGCGAAACATTGCATC
TTCTTTCTACGCCTAATAACGCTTCGCGCTTGCGATCGGCTATTGCACAATTAGATGCCAATAATGGTGAAGAACACGAG
CTTATTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT211506 WP_000079928.1 NZ_CP080258:63841-64110 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT211506 NZ_CP104890:2569-2835 [Bartonella sp. HY761]
ATGAAATTGACATTTTCAACTGAGGCTTGGGAAGATTATCAATATTGGATAAGCACAGACAAAAAGAAGCTTGAACGTAT
TAATGAAATTATTACGCAATGCCAAAGAACACCCTATAAAGGCATAGGTAAACCAGAACCTTTAAAAGGCGATCTAAGCG
GATGGTGGTCAAGACGTATCACACAAGAACATCGAATAGTCTATCGCATTTCAGGGGAGAAACAAGCGCAAAGCTTAGAA
ATAGCACAATTGCGTTTTCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References