21017

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4646891..4647417 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name relE Uniprot ID Q7N0D1
Locus tag PLU_RS19635 Protein ID WP_011148093.1
Coordinates 4647142..4647417 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6L9JMF5
Locus tag PLU_RS19630 Protein ID WP_036778328.1
Coordinates 4646891..4647139 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS19610 (plu3955) 4642625..4643038 - 414 WP_011148089.1 DUF2628 domain-containing protein -
PLU_RS19615 (plu3956) 4643450..4644154 + 705 WP_011148090.1 DUF1190 family protein -
PLU_RS19620 (plu3957) 4644161..4645321 + 1161 WP_011148091.1 glutathionylspermidine synthase family protein -
PLU_RS19625 (plu3958) 4645475..4646500 + 1026 WP_011146066.1 IS630-like element ISPlu3 family transposase -
PLU_RS19630 (plu3959) 4646891..4647139 + 249 WP_036778328.1 ribbon-helix-helix domain-containing protein Antitoxin
PLU_RS19635 (plu3960) 4647142..4647417 + 276 WP_011148093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PLU_RS26930 (plu3961) 4647431..4647589 - 159 WP_011148094.1 hypothetical protein -
PLU_RS19640 (plu3962) 4647656..4648441 - 786 WP_011148095.1 4,5-DOPA dioxygenase extradiol -
PLU_RS19645 (plu3963) 4648636..4649289 - 654 WP_011148096.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
PLU_RS19650 (plu3964) 4649749..4650039 + 291 WP_011148097.1 accessory factor UbiK family protein -
PLU_RS19655 (plu3965) 4650119..4650781 - 663 WP_011148098.1 DUF799 domain-containing protein -
PLU_RS19660 (plu3966) 4650778..4651137 - 360 WP_011148099.1 DUF4810 domain-containing protein -
PLU_RS19665 (plu3967) 4651159..4651830 - 672 WP_011148100.1 CsgG/HfaB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4645475..4646500 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10949.42 Da        Isoelectric Point: 6.9761

>T21017 WP_011148093.1 NC_005126:4647142-4647417 [Photorhabdus laumondii subsp. laumondii TTO1]
MEVYWTLKAQNDLERIYHFACQYSKSHANNVLDHLIISTTDLALQPKIGIPQPRYKPREVRKVLFSDYEVHYEISNDTIY
IVDLWHTRENR

Download         Length: 276 bp

>T21017 NC_005126:4647142-4647417 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGAGGTTTATTGGACACTTAAAGCTCAAAATGATTTGGAGCGCATCTATCATTTTGCCTGTCAATACAGTAAATCACA
TGCTAATAATGTGTTAGACCATCTAATTATCAGCACTACAGATCTGGCACTGCAACCTAAGATAGGGATTCCTCAGCCTA
GATATAAGCCCCGCGAGGTACGTAAGGTACTTTTTAGTGATTACGAAGTCCATTACGAGATATCCAACGATACAATTTAC
ATTGTAGACCTTTGGCATACCCGCGAAAACCGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9141.62 Da        Isoelectric Point: 9.9515

>AT21017 WP_036778328.1 NC_005126:4646891-4647139 [Photorhabdus laumondii subsp. laumondii TTO1]
MSISAKQTITAQIPIKLATAINDLAKELDRSKSWIIKEALTSMIEEREHRHQMILAGLADVDTGRIVNHSDVINFASKLK
KS

Download         Length: 249 bp

>AT21017 NC_005126:4646891-4647139 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGTCCATATCAGCAAAACAGACAATTACCGCACAGATACCGATCAAACTAGCTACAGCCATAAACGATTTAGCCAAAGA
GTTAGACCGCTCAAAATCGTGGATCATTAAAGAGGCTCTTACCTCAATGATTGAGGAACGTGAACATCGCCACCAAATGA
TTTTGGCTGGCCTCGCGGATGTCGATACAGGCCGTATTGTGAATCATTCAGATGTTATTAATTTTGCATCCAAGCTGAAA
AAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JLM3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JMF5

References