89219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4645608..4646134 Replicon chromosome
Accession NZ_CP024901
Organism Photorhabdus laumondii subsp. laumondii strain TT01

Toxin (Protein)


Gene name relE Uniprot ID Q7N0D1
Locus tag PluTT01m_RS20380 Protein ID WP_011148093.1
Coordinates 4645859..4646134 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6L9JMF5
Locus tag PluTT01m_RS20375 Protein ID WP_036778328.1
Coordinates 4645608..4645856 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluTT01m_RS20355 4641342..4641755 - 414 WP_011148089.1 DUF2628 domain-containing protein -
PluTT01m_RS20360 4642167..4642871 + 705 WP_011148090.1 DUF1190 family protein -
PluTT01m_RS20365 4642878..4644038 + 1161 WP_011148091.1 glutathionylspermidine synthase family protein -
PluTT01m_RS20370 4644192..4645217 + 1026 WP_011146066.1 IS630-like element ISPlu3 family transposase -
PluTT01m_RS20375 4645608..4645856 + 249 WP_036778328.1 ribbon-helix-helix domain-containing protein Antitoxin
PluTT01m_RS20380 4645859..4646134 + 276 WP_011148093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluTT01m_RS27015 4646148..4646306 - 159 WP_011148094.1 hypothetical protein -
PluTT01m_RS20385 4646373..4647158 - 786 WP_011148095.1 4,5-DOPA dioxygenase extradiol -
PluTT01m_RS20390 4647353..4648006 - 654 WP_011148096.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
PluTT01m_RS20395 4648466..4648756 + 291 WP_011148097.1 accessory factor UbiK family protein -
PluTT01m_RS20400 4648836..4649498 - 663 WP_011148098.1 DUF799 domain-containing protein -
PluTT01m_RS20405 4649495..4649854 - 360 WP_011148099.1 DUF4810 domain-containing protein -
PluTT01m_RS20410 4649876..4650547 - 672 WP_011148100.1 CsgG/HfaB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4644192..4645217 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10949.42 Da        Isoelectric Point: 6.9761

>T89219 WP_011148093.1 NZ_CP024901:4645859-4646134 [Photorhabdus laumondii subsp. laumondii]
MEVYWTLKAQNDLERIYHFACQYSKSHANNVLDHLIISTTDLALQPKIGIPQPRYKPREVRKVLFSDYEVHYEISNDTIY
IVDLWHTRENR

Download         Length: 276 bp

>T89219 NZ_CP024901:4645859-4646134 [Photorhabdus laumondii subsp. laumondii]
ATGGAGGTTTATTGGACACTTAAAGCTCAAAATGATTTGGAGCGCATCTATCATTTTGCCTGTCAATACAGTAAATCACA
TGCTAATAATGTGTTAGACCATCTAATTATCAGCACTACAGATCTGGCACTGCAACCTAAGATAGGGATTCCTCAGCCTA
GATATAAGCCCCGCGAGGTACGTAAGGTACTTTTTAGTGATTACGAAGTCCATTACGAGATATCCAACGATACAATTTAC
ATTGTAGACCTTTGGCATACCCGCGAAAACCGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9141.62 Da        Isoelectric Point: 9.9515

>AT89219 WP_036778328.1 NZ_CP024901:4645608-4645856 [Photorhabdus laumondii subsp. laumondii]
MSISAKQTITAQIPIKLATAINDLAKELDRSKSWIIKEALTSMIEEREHRHQMILAGLADVDTGRIVNHSDVINFASKLK
KS

Download         Length: 249 bp

>AT89219 NZ_CP024901:4645608-4645856 [Photorhabdus laumondii subsp. laumondii]
ATGTCCATATCAGCAAAACAGACAATTACCGCACAGATACCGATCAAACTAGCTACAGCCATAAACGATTTAGCCAAAGA
GTTAGACCGCTCAAAATCGTGGATCATTAAAGAGGCTCTTACCTCAATGATTGAGGAACGTGAACATCGCCACCAAATGA
TTTTGGCTGGCCTCGCGGATGTCGATACAGGCCGTATTGTGAATCATTCAGATGTTATTAATTTTGCATCCAAGCTGAAA
AAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JLM3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JMF5

References