Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4646889..4647415 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag A4R40_RS20380 Protein ID WP_109791823.1
Coordinates 4647140..4647415 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6L9JMF5
Locus tag A4R40_RS20375 Protein ID WP_036778328.1
Coordinates 4646889..4647137 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS20355 4642623..4643036 - 414 WP_011148089.1 DUF2628 domain-containing protein -
A4R40_RS20360 4643448..4644152 + 705 WP_011148090.1 DUF1190 family protein -
A4R40_RS20365 4644159..4645319 + 1161 WP_109791822.1 glutathionylspermidine synthase family protein -
A4R40_RS20370 4645473..4646498 + 1026 WP_109791477.1 IS630-like element ISPlu3 family transposase -
A4R40_RS20375 4646889..4647137 + 249 WP_036778328.1 ribbon-helix-helix domain-containing protein Antitoxin
A4R40_RS20380 4647140..4647415 + 276 WP_109791823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS26175 4647429..4647587 - 159 WP_011148094.1 hypothetical protein -
A4R40_RS20385 4647654..4648439 - 786 WP_058589147.1 4,5-DOPA dioxygenase extradiol -
A4R40_RS20390 4648634..4649287 - 654 WP_011148096.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
A4R40_RS20395 4649747..4650037 + 291 WP_058589148.1 accessory factor UbiK family protein -
A4R40_RS20400 4650117..4650779 - 663 WP_058589149.1 DUF799 domain-containing protein -
A4R40_RS20405 4650776..4651135 - 360 WP_109791824.1 DUF4810 domain-containing protein -
A4R40_RS20410 4651157..4651828 - 672 WP_011148100.1 CsgG/HfaB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4645473..4646498 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10945.43 Da        Isoelectric Point: 6.9761

>T62858 WP_109791823.1 NZ_CP015281:4647140-4647415 [Photorhabdus laumondii subsp. laumondii]
MEVYWTLKAQNDLERIYHFACQYSKSHANNVLDHLIISTTDLALQPKIGIPQPRYKPREVRKVLFSDYEVHYEISNDTIY
IVDLWHPRENR

Download         Length: 276 bp

>T62858 NZ_CP015281:4647140-4647415 [Photorhabdus laumondii subsp. laumondii]
ATGGAGGTTTATTGGACACTTAAAGCTCAAAATGATTTGGAGCGCATCTATCATTTTGCCTGTCAATACAGTAAATCACA
TGCTAATAATGTGTTAGACCATCTAATTATCAGCACTACAGATCTGGCACTGCAACCTAAGATAGGGATTCCTCAGCCTA
GATATAAGCCCCGCGAGGTACGTAAGGTACTTTTTAGTGATTACGAAGTCCATTACGAGATATCCAACGATACAATTTAC
ATTGTAGACCTTTGGCATCCCCGCGAAAACCGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9141.62 Da        Isoelectric Point: 9.9515

>AT62858 WP_036778328.1 NZ_CP015281:4646889-4647137 [Photorhabdus laumondii subsp. laumondii]
MSISAKQTITAQIPIKLATAINDLAKELDRSKSWIIKEALTSMIEEREHRHQMILAGLADVDTGRIVNHSDVINFASKLK
KS

Download         Length: 249 bp

>AT62858 NZ_CP015281:4646889-4647137 [Photorhabdus laumondii subsp. laumondii]
ATGTCCATATCAGCAAAACAGACAATTACCGCACAGATACCGATCAAACTAGCTACAGCCATAAACGATTTAGCCAAAGA
GTTAGACCGCTCAAAATCGTGGATCATTAAAGAGGCTCTTACCTCAATGATTGAGGAACGTGAACATCGCCACCAAATGA
TTTTGGCTGGCCTCGCGGATGTCGATACAGGCCGTATTGTGAATCATTCAGATGTTATTAATTTTGCATCCAAGCTGAAA
AAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JMF5

References