21003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2676127..2676673 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name ccdB Uniprot ID Q7N4P3
Locus tag PLU_RS11375 Protein ID WP_011146528.1
Coordinates 2676368..2676673 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7N4P4
Locus tag PLU_RS11370 Protein ID WP_011146527.1
Coordinates 2676127..2676366 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS11350 (plu2274) 2671570..2672754 - 1185 WP_109791559.1 DNA-binding transcriptional regulator -
PLU_RS11355 (plu2275) 2673062..2674381 + 1320 WP_011146524.1 xylose isomerase -
PLU_RS11360 (plu2276) 2674801..2675373 + 573 WP_011146525.1 hypothetical protein -
PLU_RS11365 (plu2277) 2675665..2676039 + 375 WP_041380079.1 VOC family protein -
PLU_RS11370 (plu2278) 2676127..2676366 + 240 WP_011146527.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PLU_RS11375 (plu2279) 2676368..2676673 + 306 WP_011146528.1 CcdB family protein Toxin
PLU_RS25325 2676792..2676884 - 93 WP_071824109.1 type II toxin-antitoxin system YoeB family toxin -
PLU_RS11380 (plu2280) 2676944..2677198 - 255 WP_011146529.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
PLU_RS24565 (plu2281) 2677254..2677712 - 459 WP_011146530.1 Exc2 family lipoprotein -
PLU_RS11390 (plu2282) 2677694..2678662 - 969 WP_011145223.1 IS30-like element ISPlu1 family transposase -
PLU_RS11395 (plu2283) 2678805..2679005 - 201 WP_011146531.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2677694..2678662 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11682.71 Da        Isoelectric Point: 5.0479

>T21003 WP_011146528.1 NC_005126:2676368-2676673 [Photorhabdus laumondii subsp. laumondii TTO1]
MQYVVYRNIGNSAYPYLLDVQSDIIDMLNTRLMIPLFLKENFKGKVPIRLCPILTIEESDYIVMTHEMASIRVSMIGNEV
IDVTSHRKQIKDALDFLIDGF

Download         Length: 306 bp

>T21003 NC_005126:2676368-2676673 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCAGTATGTTGTTTATCGCAATATTGGCAATTCTGCTTACCCATATCTTCTTGACGTACAGAGTGACATTATTGATAT
GTTGAATACAAGATTAATGATACCCCTGTTTCTGAAAGAAAATTTTAAAGGCAAAGTTCCTATAAGATTATGTCCAATAT
TGACAATTGAGGAGAGTGACTACATCGTCATGACTCATGAAATGGCAAGTATCAGAGTATCTATGATCGGTAATGAAGTT
ATTGATGTCACATCCCACCGGAAACAAATTAAAGATGCTTTGGATTTTCTCATTGATGGATTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8997.44 Da        Isoelectric Point: 10.3135

>AT21003 WP_011146527.1 NC_005126:2676127-2676366 [Photorhabdus laumondii subsp. laumondii TTO1]
MPATQIRLKKTVSVTVAPELYQQARQVGLNLSAVLTKALISELKAVESERWKRENKAGMEELNRITNEHGLLSDKYRVF

Download         Length: 240 bp

>AT21003 NC_005126:2676127-2676366 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCCAGCAACACAAATCAGATTAAAGAAAACAGTGAGCGTGACCGTTGCACCTGAACTGTATCAACAAGCGAGACAGGT
AGGGCTTAACTTATCAGCAGTGCTGACTAAAGCACTAATTTCGGAACTGAAAGCCGTTGAGTCTGAACGCTGGAAACGTG
AGAATAAGGCAGGAATGGAAGAACTTAATCGTATCACTAACGAACACGGTTTACTGTCTGACAAGTACAGGGTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JP64

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JTQ5

References