62844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2676126..2676672 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name ccdB Uniprot ID Q7N4P3
Locus tag A4R40_RS11780 Protein ID WP_011146528.1
Coordinates 2676367..2676672 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7N4P4
Locus tag A4R40_RS11775 Protein ID WP_011146527.1
Coordinates 2676126..2676365 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS11755 2671569..2672753 - 1185 WP_109791559.1 DNA-binding transcriptional regulator -
A4R40_RS11760 2673061..2674380 + 1320 WP_011146524.1 xylose isomerase -
A4R40_RS11765 2674800..2675372 + 573 WP_011146525.1 hypothetical protein -
A4R40_RS11770 2675664..2676038 + 375 WP_041380079.1 VOC family protein -
A4R40_RS11775 2676126..2676365 + 240 WP_011146527.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
A4R40_RS11780 2676367..2676672 + 306 WP_011146528.1 CcdB family protein Toxin
A4R40_RS11785 2676791..2676883 - 93 WP_071824109.1 type II toxin-antitoxin system YoeB family toxin -
A4R40_RS11790 2676943..2677197 - 255 WP_011146529.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
A4R40_RS11795 2677253..2677711 - 459 WP_109791560.1 Exc2 family lipoprotein -
A4R40_RS11800 2677693..2678661 - 969 WP_011145223.1 IS30-like element ISPlu1 family transposase -
A4R40_RS11805 2678804..2679004 - 201 WP_011146531.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2677693..2678661 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11682.71 Da        Isoelectric Point: 5.0479

>T62844 WP_011146528.1 NZ_CP015281:2676367-2676672 [Photorhabdus laumondii subsp. laumondii]
MQYVVYRNIGNSAYPYLLDVQSDIIDMLNTRLMIPLFLKENFKGKVPIRLCPILTIEESDYIVMTHEMASIRVSMIGNEV
IDVTSHRKQIKDALDFLIDGF

Download         Length: 306 bp

>T62844 NZ_CP015281:2676367-2676672 [Photorhabdus laumondii subsp. laumondii]
ATGCAGTATGTTGTTTATCGCAATATTGGCAATTCTGCTTACCCATATCTTCTTGACGTACAGAGTGACATTATTGATAT
GTTGAATACAAGATTAATGATACCCCTGTTTCTGAAAGAAAATTTTAAAGGCAAAGTTCCTATAAGATTATGTCCAATAT
TGACAATTGAGGAGAGTGACTACATCGTCATGACTCATGAAATGGCAAGTATCAGAGTATCTATGATCGGTAATGAAGTT
ATTGATGTCACATCCCACCGGAAACAAATTAAAGATGCTTTGGATTTTCTCATTGATGGATTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8997.44 Da        Isoelectric Point: 10.3135

>AT62844 WP_011146527.1 NZ_CP015281:2676126-2676365 [Photorhabdus laumondii subsp. laumondii]
MPATQIRLKKTVSVTVAPELYQQARQVGLNLSAVLTKALISELKAVESERWKRENKAGMEELNRITNEHGLLSDKYRVF

Download         Length: 240 bp

>AT62844 NZ_CP015281:2676126-2676365 [Photorhabdus laumondii subsp. laumondii]
ATGCCAGCAACACAAATCAGATTAAAGAAAACAGTGAGCGTGACCGTTGCACCTGAACTGTATCAACAAGCGAGACAGGT
AGGGCTTAACTTATCAGCAGTGCTGACTAAAGCACTAATTTCGGAACTGAAAGCCGTTGAGTCTGAACGCTGGAAACGTG
AGAATAAGGCAGGAATGGAAGAACTTAATCGTATCACTAACGAACACGGTTTACTGTCTGACAAGTACAGGGTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JP64

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JTQ5

References