199401

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1111217..1111884 Replicon chromosome
Accession NZ_CP072986
Organism Escherichia coli strain T159A

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag KBW97_RS05300 Protein ID WP_001094400.1
Coordinates 1111217..1111546 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag KBW97_RS05305 Protein ID WP_000072690.1
Coordinates 1111567..1111884 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBW97_RS05295 (1106273) 1106273..1110853 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
KBW97_RS05300 (1111217) 1111217..1111546 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
KBW97_RS05305 (1111567) 1111567..1111884 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KBW97_RS05310 (1111922) 1111922..1112122 - 201 WP_001395452.1 DUF987 domain-containing protein -
KBW97_RS05315 (1112131) 1112131..1112613 - 483 WP_001407480.1 RadC family protein -
KBW97_RS05320 (1112622) 1112622..1113080 - 459 WP_000211841.1 antirestriction protein -
KBW97_RS05325 (1113183) 1113183..1113367 - 185 Protein_1054 DUF905 family protein -
KBW97_RS05330 (1113978) 1113978..1115681 - 1704 WP_000896263.1 protein YfjW -
KBW97_RS05335 (1115823) 1115823..1116832 + 1010 Protein_1056 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1101565..1133445 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T199401 WP_001094400.1 NZ_CP072986:c1111546-1111217 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T199401 NZ_CP097336:1470705-1471013 [Mannheimia haemolytica]
ATAATGGAAAGCAAACCATTAAAAGTGAGTTATTCTAAACAGTTTGTGAGGGATTTAACTGATTTGGCTAAACGACACCC
TAACGTACTGATTGGCACAAAATACATTACTGCTATTCACTGCCTTCTCAATCGTTTACCTTTACCGGAGGGCTATCAAG
ATCATGCCTTATCCGGTGAATGGAAAGGTTATCGTGACTGCCATATCCAAGGGGATTTAGTGCTGATATACCAATATGTT
ATTCACGATGAATTTGATGAACTCAAATTCGCTCGCTTAAACACACACTCACAAACAGCATTAAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT199401 WP_000072690.1 NZ_CP072986:c1111884-1111567 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT199401 NZ_CP097336:1470412-1470708 [Mannheimia haemolytica]
ATGGCGATTACGGATGCTTCAATCAGTTTCAGAACAGTTGAACGCACAAAAGCAGAAGCCTATCAAGTCATTGAACAATA
TGGGTTAACTCCATCTCAAGTGTTTAATATGTTCTTAAACCAAATTGCAAAGACACGTTCTATTCCGGTAGATTTAAACT
ATCTTCGCCCGAATAAAGACACATTATCGGCAATGGATGAACTGGATAATGGTTCAGCTGCCAGTTTTTTTATCGAAGCC
GGTGAAAATTATTCTACTGAAGAGTTCACAAAACGAATTCTTAATGGTGGACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References