Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT_toxin-BrnA |
| Location | 1826297..1826786 | Replicon | chromosome |
| Accession | NZ_CP071752 | ||
| Organism | Burkholderia pseudomallei strain VBM23831 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | Q63NA2 |
| Locus tag | J3C54_RS24530 | Protein ID | WP_004547086.1 |
| Coordinates | 1826565..1826786 (-) | Length | 74 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | - |
| Locus tag | J3C54_RS24525 | Protein ID | WP_038730768.1 |
| Coordinates | 1826297..1826581 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3C54_RS24500 (J3C54_24500) | 1821405..1822667 | - | 1263 | WP_004530738.1 | cytochrome c peroxidase | - |
| J3C54_RS24505 (J3C54_24505) | 1822826..1824286 | - | 1461 | WP_028358298.1 | metallophosphoesterase | - |
| J3C54_RS24510 (J3C54_24510) | 1824533..1824649 | + | 117 | Protein_1442 | IS3 family transposase | - |
| J3C54_RS24515 (J3C54_24515) | 1824876..1825268 | - | 393 | Protein_1443 | IS110 family transposase | - |
| J3C54_RS24520 (J3C54_24520) | 1825267..1825650 | - | 384 | Protein_1444 | integrase core domain-containing protein | - |
| J3C54_RS24525 (J3C54_24525) | 1826297..1826581 | - | 285 | WP_038730768.1 | BrnA antitoxin family protein | Antitoxin |
| J3C54_RS24530 (J3C54_24530) | 1826565..1826786 | - | 222 | WP_004547086.1 | BrnT family toxin | Toxin |
| J3C54_RS24535 (J3C54_24535) | 1827405..1827680 | + | 276 | WP_004552388.1 | bacteriophage protein Gp49 | - |
| J3C54_RS24540 (J3C54_24540) | 1827690..1827821 | + | 132 | WP_009923452.1 | bacteriophage protein Gp48 | - |
| J3C54_RS24545 (J3C54_24545) | 1827959..1828201 | + | 243 | WP_207876237.1 | hypothetical protein | - |
| J3C54_RS24550 (J3C54_24550) | 1828198..1828356 | + | 159 | WP_004549802.1 | hypothetical protein | - |
| J3C54_RS24555 (J3C54_24555) | 1828404..1828622 | + | 219 | WP_004552392.1 | hypothetical protein | - |
| J3C54_RS24560 (J3C54_24560) | 1828853..1829434 | - | 582 | WP_004542548.1 | hypothetical protein | - |
| J3C54_RS24565 (J3C54_24565) | 1829690..1829839 | + | 150 | WP_004537646.1 | bacteriophage protein Gp44 | - |
| J3C54_RS24570 (J3C54_24570) | 1829875..1830408 | + | 534 | Protein_1454 | SPFH domain-containing protein | - |
| J3C54_RS24575 (J3C54_24575) | 1830607..1831035 | + | 429 | Protein_1455 | integrase core domain-containing protein | - |
| J3C54_RS24580 (J3C54_24580) | 1831139..1831405 | - | 267 | WP_123850280.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1825267..1833864 | 8597 | |
| flank | IS/Tn | - | - | 1825267..1825563 | 296 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 74 a.a. Molecular weight: 8634.77 Da Isoelectric Point: 8.4920
>T196851 WP_004547086.1 NZ_CP071752:c1826786-1826565 [Burkholderia pseudomallei]
MECRWRLQRNSTGQDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREVKSYVEQA
MECRWRLQRNSTGQDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREVKSYVEQA
Download Length: 222 bp
>T196851 NZ_CP095462:2655765-2656115 [Bacillus sp. JY-23]
TTGATCGTAAAACGCGGTGACGTGTATTTTGCAGACCTTTCTCCGGTTGTTGGTTCTGAGCAAGGCGGGGTTCGCCCTGT
GCTCGTCATACAAAATGATATTGGAAACCGATTTAGCCCCACTGTGATTGTTGCTGCTATTACAGCACAAATTCAAAAGG
CTAAATTGCCTACGCACGTGGAGATTGATGCCAAGCGCTACGGGTTTGAAAGGGATTCTGTTATTTTGTTAGAGCAAATT
CGTACCATTGACAAACAGCGTTTAACCGATAAAATTACCCACTTAGATGATGGCATGATGCATCGAGTGGATGAAGCTTT
GCAAATTAGTTTAGGACTTATAGATTTTTAA
TTGATCGTAAAACGCGGTGACGTGTATTTTGCAGACCTTTCTCCGGTTGTTGGTTCTGAGCAAGGCGGGGTTCGCCCTGT
GCTCGTCATACAAAATGATATTGGAAACCGATTTAGCCCCACTGTGATTGTTGCTGCTATTACAGCACAAATTCAAAAGG
CTAAATTGCCTACGCACGTGGAGATTGATGCCAAGCGCTACGGGTTTGAAAGGGATTCTGTTATTTTGTTAGAGCAAATT
CGTACCATTGACAAACAGCGTTTAACCGATAAAATTACCCACTTAGATGATGGCATGATGCATCGAGTGGATGAAGCTTT
GCAAATTAGTTTAGGACTTATAGATTTTTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10678.05 Da Isoelectric Point: 5.7409
>AT196851 WP_038730768.1 NZ_CP071752:c1826581-1826297 [Burkholderia pseudomallei]
MSSKHKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA
MSSKHKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA
Download Length: 285 bp
>AT196851 NZ_CP095462:2655472-2655759 [Bacillus sp. JY-23]
GTGTCTGAATCGAGCGTAACAACAGAGATTGTGATTCGCTTGCCAAAGCAAATCATATCTGAGTTAGACGGGATCGTACA
ACGTGAGAATTGTAACCGAAATGAGTTGATTTGCGAGGCGGCCAAAATGTTTTTGCGGCAGCACAAAACGAAAAAGAAGT
ATCAGCATGATTCCATCAGACGCGGATATATTGAAATGGGAGAGATTAATCTAAATATTGCCTCTGAATCCTTCTTAGCG
GAGTATGAAGCAGCTCATACGGTAGAACGCTTAGTTAGCGGGGGGTAA
GTGTCTGAATCGAGCGTAACAACAGAGATTGTGATTCGCTTGCCAAAGCAAATCATATCTGAGTTAGACGGGATCGTACA
ACGTGAGAATTGTAACCGAAATGAGTTGATTTGCGAGGCGGCCAAAATGTTTTTGCGGCAGCACAAAACGAAAAAGAAGT
ATCAGCATGATTCCATCAGACGCGGATATATTGAAATGGGAGAGATTAATCTAAATATTGCCTCTGAATCCTTCTTAGCG
GAGTATGAAGCAGCTCATACGGTAGAACGCTTAGTTAGCGGGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|