Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 792336..793773 | Replicon | chromosome |
| Accession | NZ_CP070962 | ||
| Organism | Escherichia coli strain K-12 J53 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | JTR57_RS03890 | Protein ID | WP_000155570.1 |
| Coordinates | 792700..793773 (-) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | JTR57_RS03885 | Protein ID | WP_000461704.1 |
| Coordinates | 792336..792707 (-) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JTR57_RS23315 (787537) | 787537..787689 | + | 153 | Protein_751 | arsenate reductase | - |
| JTR57_RS03855 (788076) | 788076..788543 | - | 468 | WP_000702495.1 | protein YfjT | - |
| JTR57_RS03860 (788567) | 788567..789010 | - | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| JTR57_RS03865 (789010) | 789010..789246 | - | 237 | WP_001144029.1 | protein YpjK | - |
| JTR57_RS03870 (789287) | 789287..789988 | - | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| JTR57_RS03875 (790205) | 790205..791026 | - | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| JTR57_RS03880 (791118) | 791118..791981 | - | 864 | WP_000787597.1 | GTPase family protein | - |
| JTR57_RS03885 (792336) | 792336..792707 | - | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| JTR57_RS03890 (792700) | 792700..793773 | - | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| JTR57_RS03895 (793915) | 793915..794178 | + | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| JTR57_RS03900 (794538) | 794538..796154 | + | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| JTR57_RS03905 (796151) | 796151..798340 | + | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 772259..804137 | 31878 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T194805 WP_000155570.1 NZ_CP070962:c793773-792700 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
>T194805 NZ_CP094082:610779-611051 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGTTAGGCAGTCATAGCGAGCTGTTTTAA
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGTTAGGCAGTCATAGCGAGCTGTTTTAA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT194805 WP_000461704.1 NZ_CP070962:c792707-792336 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
>AT194805 NZ_CP094082:610481-610792 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTGACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACTGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAGAAAGCATTGTGAAAACTTAAGACTTAAAAATGCTGATGATTGA
ATGCCTAACTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTGACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACTGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAGAAAGCATTGTGAAAACTTAAGACTTAAAAATGCTGATGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|