186389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1111175..1111842 Replicon chromosome
Accession NZ_CP067994
Organism Escherichia coli strain CV601

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag JJT18_RS05300 Protein ID WP_001094400.1
Coordinates 1111175..1111504 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag JJT18_RS05305 Protein ID WP_000072690.1
Coordinates 1111525..1111842 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJT18_RS05295 1106231..1110811 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
JJT18_RS05300 1111175..1111504 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
JJT18_RS05305 1111525..1111842 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JJT18_RS05310 1111880..1112080 - 201 WP_001395452.1 DUF987 domain-containing protein -
JJT18_RS05315 1112089..1112571 - 483 WP_001407480.1 RadC family protein -
JJT18_RS05320 1112580..1113038 - 459 WP_000211841.1 antirestriction protein -
JJT18_RS05325 1113141..1113364 - 224 Protein_1038 DUF905 family protein -
JJT18_RS05330 1113936..1115639 - 1704 WP_000896263.1 hypothetical protein -
JJT18_RS05335 1115781..1116790 + 1010 Protein_1040 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1101523..1133403 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T186389 WP_001094400.1 NZ_CP067994:c1111504-1111175 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T186389 NZ_CP089407:5410250-5410624 [Klebsiella michiganensis]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTATGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTGGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT186389 WP_000072690.1 NZ_CP067994:c1111842-1111525 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT186389 NZ_CP089407:5410032-5410253 [Klebsiella michiganensis]
ATGCGCTCATACAGTACATCTGAAGCCAGACAGAATATTGCGGCCGTCATGGACGCCGCTGCCAGCGGAGAACCGATTGA
AATTACACGGCGTGATGGAACGTCTAATGTTTTGATCAGTAAGGCGGAATATGAAACGTTTATGAATGCCAAACTTGATG
CGGAGTTTGATTTTATTATGCAGCGACACGGCCGCACAGTTAAGGCGTTGACCGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References