136295

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1107436..1108103 Replicon chromosome
Accession NZ_CP042865
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag BAA196NC_RS05330 Protein ID WP_001094400.1
Coordinates 1107436..1107765 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag BAA196NC_RS05335 Protein ID WP_000072690.1
Coordinates 1107786..1108103 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196NC_RS05325 1102492..1107072 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
BAA196NC_RS05330 1107436..1107765 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
BAA196NC_RS05335 1107786..1108103 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BAA196NC_RS05340 1108141..1108341 - 201 WP_001395452.1 DUF987 domain-containing protein -
BAA196NC_RS05345 1108350..1108832 - 483 WP_001407480.1 RadC family protein -
BAA196NC_RS05350 1108841..1109299 - 459 WP_000211841.1 antirestriction protein -
BAA196NC_RS05355 1109402..1109625 - 224 Protein_1041 DUF905 domain-containing protein -
BAA196NC_RS05360 1110197..1111900 - 1704 WP_000896263.1 hypothetical protein -
BAA196NC_RS05365 1112042..1113051 + 1010 Protein_1043 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1097784..1129664 31880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T136295 WP_001094400.1 NZ_CP042865:c1107765-1107436 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T136295 NZ_CP042865:c1107765-1107436 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT136295 WP_000072690.1 NZ_CP042865:c1108103-1107786 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT136295 NZ_CP042865:c1108103-1107786 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References