119842

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 510623..511064 Replicon chromosome
Accession NZ_CP036453
Organism Burkholderia pseudomallei strain BPs111

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag EXY72_RS02690 Protein ID WP_009939402.1
Coordinates 510891..511064 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag EXY72_RS02685 Protein ID WP_004525420.1
Coordinates 510623..510907 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXY72_RS02655 506925..507245 + 321 WP_004196029.1 DUF4212 domain-containing protein -
EXY72_RS02660 507239..509254 + 2016 WP_004525415.1 cation acetate symporter -
EXY72_RS02670 509570..509977 - 408 Protein_412 DDE-type integrase/transposase/recombinase -
EXY72_RS02685 510623..510907 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
EXY72_RS02690 510891..511064 - 174 WP_009939402.1 BrnT family toxin Toxin
EXY72_RS02695 511732..512007 + 276 WP_004552388.1 bacteriophage protein Gp49 -
EXY72_RS02700 512017..512148 + 132 WP_009923452.1 bacteriophage protein Gp48 -
EXY72_RS02715 512729..513319 - 591 WP_038717720.1 hypothetical protein -
EXY72_RS02720 513569..513718 + 150 WP_004537646.1 bacteriophage protein Gp44 -
EXY72_RS02725 513715..514488 + 774 Protein_419 prohibitin family protein -
EXY72_RS37220 514486..514890 + 405 Protein_420 DDE-type integrase/transposase/recombinase -
EXY72_RS02730 514853..515281 + 429 Protein_421 IS110 family transposase -
EXY72_RS02735 515508..515624 - 117 Protein_422 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - ddhA 509451..582562 73111
flank IS/Tn - - 509570..509890 320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(4-49)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6691.59 Da        Isoelectric Point: 7.9950

>T119842 WP_009939402.1 NZ_CP036453:c511064-510891 [Burkholderia pseudomallei]
MSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREVKSYVEQA

Download         Length: 174 bp

>T119842 NZ_CP036453:c511064-510891 [Burkholderia pseudomallei]
TTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCGGCGATCGCCTCTATTG
CGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGGGAGGTCAAGAGCTATG
TCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT119842 WP_004525420.1 NZ_CP036453:c510907-510623 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT119842 NZ_CP036453:c510907-510623 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGCCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACCGTGCGTTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References