119840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 501239..501680 Replicon chromosome
Accession NZ_CP036451
Organism Burkholderia pseudomallei strain BPs110

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag EXY28_RS02655 Protein ID WP_009939402.1
Coordinates 501507..501680 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag EXY28_RS02650 Protein ID WP_004525420.1
Coordinates 501239..501523 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXY28_RS02620 497621..497941 + 321 WP_004196029.1 DUF4212 domain-containing protein -
EXY28_RS02625 497935..499950 + 2016 WP_004525415.1 cation acetate symporter -
EXY28_RS02635 500186..500593 - 408 Protein_413 DDE-type integrase/transposase/recombinase -
EXY28_RS02650 501239..501523 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
EXY28_RS02655 501507..501680 - 174 WP_009939402.1 BrnT family toxin Toxin
EXY28_RS02660 502348..502623 + 276 WP_009975384.1 hypothetical protein -
EXY28_RS02665 502633..502764 + 132 WP_009923452.1 bacteriophage protein Gp48 -
EXY28_RS36380 502952..503170 + 219 WP_004552392.1 hypothetical protein -
EXY28_RS02680 503345..503935 - 591 WP_038717720.1 hypothetical protein -
EXY28_RS02685 504185..504334 + 150 WP_004537646.1 bacteriophage protein Gp44 -
EXY28_RS02690 504331..505104 + 774 Protein_421 prohibitin family protein -
EXY28_RS37220 505102..505506 + 405 Protein_422 DDE-type integrase/transposase/recombinase -
EXY28_RS02695 505469..505897 + 429 Protein_423 IS110 family transposase -
EXY28_RS02700 506124..506240 - 117 Protein_424 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 497935..511551 13616
flank IS/Tn - - 500186..500506 320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(4-49)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6691.59 Da        Isoelectric Point: 7.9950

>T119840 WP_009939402.1 NZ_CP036451:c501680-501507 [Burkholderia pseudomallei]
MSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREVKSYVEQA

Download         Length: 174 bp

>T119840 NZ_CP036451:c501680-501507 [Burkholderia pseudomallei]
TTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCGGCGATCGCCTCTATTG
CGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGGGAGGTCAAGAGCTATG
TCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT119840 WP_004525420.1 NZ_CP036451:c501523-501239 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT119840 NZ_CP036451:c501523-501239 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGCCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACCGTGCGTTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References