Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/- |
| Location | 263328..264007 | Replicon | chromosome |
| Accession | NC_000913 | ||
| Organism | Escherichia coli str. K-12 substr. MG1655 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | P77692 |
| Locus tag | b0245 | Protein ID | NP_414779.1 |
| Coordinates | 263328..263669 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | Q47684 |
| Locus tag | b0246 | Protein ID | NP_414780.1 |
| Coordinates | 263690..264007 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| b4709 | 258345..258620 | - | 276 | YP_009518740.1 | IS1 family repressor TnpA | - |
| b0241 | 259045..260100 | - | 1056 | NP_414776.1 | outer membrane porin PhoE | - |
| b0242 | 260388..261491 | + | 1104 | NP_414777.1 | glutamate 5-kinase | - |
| b0243 | 261503..262756 | + | 1254 | NP_414778.1 | glutamate-5-semialdehyde dehydrogenase | - |
| b0245 | 263328..263669 | - | 342 | NP_414779.1 | toxin of the YkfI-YafW toxin-antitoxin system | Toxin |
| b0246 | 263690..264007 | - | 318 | NP_414780.1 | antitoxin of the YkfI-YafW toxin-antitoxin pair | Antitoxin |
| b4504 | 264026..264247 | - | 222 | YP_588435.1 | DUF987 domain-containing protein YkfH | - |
| b0247 | 264256..264732 | - | 477 | NP_414781.1 | RadC-like JAB domain-containing protein YkfG | - |
| b0248 | 264748..265206 | - | 459 | NP_414782.1 | protein YafX | - |
| b0249 | 265304..265543 | - | 240 | NP_414783.1 | protein YkfF | - |
| b0250 | 265620..266087 | - | 468 | NP_414784.1 | protein YkfB | - |
| b0251 | 266110..266553 | - | 444 | NP_414785.4 | inner membrane lipoprotein YafY | - |
| b0252 | 267184..268005 | - | 822 | NP_414786.4 | DUF932 domain-containing protein YafZ | - |
| b0253 | 268097..268960 | - | 864 | NP_414787.4 | putative GTP-binding protein YkfA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12905.01 Da Isoelectric Point: 9.6543
>T10198 NP_414779.1 NC_000913:c263669-263328 [Escherichia coli str. K-12 substr. MG1655]
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T10198 NC_000913:c263669-263328 [Escherichia coli str. K-12 substr. MG1655]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11939.59 Da Isoelectric Point: 6.7391
>AT10198 NP_414780.1 NC_000913:c264007-263690 [Escherichia coli str. K-12 substr. MG1655]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT10198 NC_000913:c264007-263690 [Escherichia coli str. K-12 substr. MG1655]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10199 | Escherichia coli str. K-12 substr. MG1655 |
80.952 |
96.33 |
0.78 |
| T10128 | Erwinia amylovora strain CTBT3-1 tig00000000 |
72.115 |
98.113 |
0.708 |
| T1042 | Escherichia coli str. K-12 substr. MG1655 |
60 |
97.345 |
0.584 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10199 | Escherichia coli str. K-12 substr. MG1655 |
83.81 |
100 |
0.838 |
| AT10128 | Erwinia amylovora strain CTBT3-1 tig00000000 |
64.948 |
92.381 |
0.6 |
| AT1042 | Escherichia coli str. K-12 substr. MG1655 |
62 |
95.238 |
0.59 |
Multiple sequence alignment
References
(1) Zhongling Wen et al. (2017) Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12. Toxins 9(3):77. [PubMed:28257056]