Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/- |
| Location | 7408..8828 | Replicon | chromosome |
| Accession | NC_007145 | ||
| Organism | Burkholderia prophage phi52237 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | Q45YI7 |
| Locus tag | BPSphi5223_0001 | Protein ID | YP_293707.1 |
| Coordinates | 7408..8352 (-) | Length | 315 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0MA36 |
| Locus tag | BPSphi5223_0049 | Protein ID | YP_863932.1 |
| Coordinates | 8355..8828 (-) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BPSphi5223_0045 | 2687..4492 | + | 1806 | YP_293751.1 | terminase large subunit | - |
| BPSphi5223_0046 | 4414..5544 | + | 1131 | YP_293752.1 | portal protein | - |
| BPSphi5223_0047 | 5549..5923 | + | 375 | YP_293753.1 | ribonuclease toxin of AT system | - |
| BPSphi5223_0048 | 5883..6155 | + | 273 | YP_293754.2 | antitoxin from a toxin-antitoxin system | - |
| BPSphi5223_0001 | 7408..8352 | - | 945 | YP_293707.1 | hypothetical protein | Toxin |
| BPSphi5223_0049 | 8355..8828 | - | 474 | YP_863932.1 | DUF4065 domain-containing protein | Antitoxin |
| BPSphi5223_0002 | 9314..10639 | - | 1326 | YP_293708.1 | integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 37..37576 | 37539 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 315 a.a. Molecular weight: 35178.12 Da Isoelectric Point: 8.4876
>T10010 YP_293707.1 NC_007145:c8352-7408 [Burkholderia phage phiE52237]
MATRKTTGTTRGRKNAAQEPDLSAIKVPVPEGKALSKLQTDYPKGVAYEERVVAFIDILGFKEWIGKSAKQAELLHRIHA
ALDIRIDGFAQAFAPLVDLKMTPNDFDDRFHSFSDFIVMSVRRDICEIGLLVFAVFKVCRTLLSYGFASRGGIAMGDLYH
RHNDPENPTAPPMVFGPAFVDAYTFESTHADGPRVILQNKVWQHIDRKCDERPSSKLSQFLRTHVHRAEDGPAYINIFAD
LGTSAFYEFSSNMDTELQAIHKHICTALDESSDRPHQFKKNAQLAREFNAALESAGLTRHLIPRTKLPKKAGAH
MATRKTTGTTRGRKNAAQEPDLSAIKVPVPEGKALSKLQTDYPKGVAYEERVVAFIDILGFKEWIGKSAKQAELLHRIHA
ALDIRIDGFAQAFAPLVDLKMTPNDFDDRFHSFSDFIVMSVRRDICEIGLLVFAVFKVCRTLLSYGFASRGGIAMGDLYH
RHNDPENPTAPPMVFGPAFVDAYTFESTHADGPRVILQNKVWQHIDRKCDERPSSKLSQFLRTHVHRAEDGPAYINIFAD
LGTSAFYEFSSNMDTELQAIHKHICTALDESSDRPHQFKKNAQLAREFNAALESAGLTRHLIPRTKLPKKAGAH
Download Length: 945 bp
>T10010 NC_007145:c8352-7408 [Burkholderia phage phiE52237]
TTGGCAACCAGAAAGACTACTGGCACCACGCGGGGACGCAAGAATGCGGCGCAGGAGCCTGATCTCTCCGCAATCAAGGT
CCCCGTCCCTGAAGGCAAAGCGCTCTCCAAACTTCAGACCGATTACCCCAAAGGGGTAGCGTATGAAGAGCGCGTTGTCG
CGTTCATTGACATCCTTGGTTTCAAGGAGTGGATCGGGAAGTCAGCGAAACAAGCTGAACTGCTCCACCGCATCCATGCA
GCATTGGACATTCGTATCGACGGTTTCGCGCAGGCGTTTGCGCCCTTAGTCGATCTCAAAATGACACCCAATGATTTCGA
CGATCGATTTCACTCGTTCTCAGACTTCATCGTCATGTCGGTCCGACGCGATATCTGTGAAATCGGCTTGCTGGTATTCG
CCGTTTTCAAGGTGTGCCGCACGCTCCTCTCTTATGGATTCGCAAGCCGCGGTGGGATCGCAATGGGTGACCTCTATCAC
CGGCACAACGACCCCGAGAACCCGACGGCGCCTCCAATGGTGTTTGGTCCCGCTTTCGTCGACGCGTATACGTTTGAGTC
GACCCACGCTGACGGGCCTCGAGTCATCCTGCAAAACAAGGTCTGGCAGCACATCGACCGAAAGTGTGATGAGCGTCCGT
CATCGAAGCTATCGCAATTCCTGCGCACGCACGTGCATCGCGCAGAAGACGGCCCGGCGTACATCAATATCTTTGCCGAC
CTTGGAACGAGCGCCTTTTACGAGTTCAGCTCGAATATGGATACCGAACTTCAGGCCATCCACAAGCACATATGCACGGC
CCTAGATGAGTCTTCGGACCGCCCTCACCAGTTCAAGAAAAACGCCCAGCTCGCGCGTGAATTTAATGCGGCCCTAGAAA
GCGCTGGCCTGACGCGACATCTGATCCCGCGAACCAAACTTCCCAAAAAGGCCGGGGCTCATTAG
TTGGCAACCAGAAAGACTACTGGCACCACGCGGGGACGCAAGAATGCGGCGCAGGAGCCTGATCTCTCCGCAATCAAGGT
CCCCGTCCCTGAAGGCAAAGCGCTCTCCAAACTTCAGACCGATTACCCCAAAGGGGTAGCGTATGAAGAGCGCGTTGTCG
CGTTCATTGACATCCTTGGTTTCAAGGAGTGGATCGGGAAGTCAGCGAAACAAGCTGAACTGCTCCACCGCATCCATGCA
GCATTGGACATTCGTATCGACGGTTTCGCGCAGGCGTTTGCGCCCTTAGTCGATCTCAAAATGACACCCAATGATTTCGA
CGATCGATTTCACTCGTTCTCAGACTTCATCGTCATGTCGGTCCGACGCGATATCTGTGAAATCGGCTTGCTGGTATTCG
CCGTTTTCAAGGTGTGCCGCACGCTCCTCTCTTATGGATTCGCAAGCCGCGGTGGGATCGCAATGGGTGACCTCTATCAC
CGGCACAACGACCCCGAGAACCCGACGGCGCCTCCAATGGTGTTTGGTCCCGCTTTCGTCGACGCGTATACGTTTGAGTC
GACCCACGCTGACGGGCCTCGAGTCATCCTGCAAAACAAGGTCTGGCAGCACATCGACCGAAAGTGTGATGAGCGTCCGT
CATCGAAGCTATCGCAATTCCTGCGCACGCACGTGCATCGCGCAGAAGACGGCCCGGCGTACATCAATATCTTTGCCGAC
CTTGGAACGAGCGCCTTTTACGAGTTCAGCTCGAATATGGATACCGAACTTCAGGCCATCCACAAGCACATATGCACGGC
CCTAGATGAGTCTTCGGACCGCCCTCACCAGTTCAAGAAAAACGCCCAGCTCGCGCGTGAATTTAATGCGGCCCTAGAAA
GCGCTGGCCTGACGCGACATCTGATCCCGCGAACCAAACTTCCCAAAAAGGCCGGGGCTCATTAG
Antitoxin
Download Length: 158 a.a. Molecular weight: 17247.59 Da Isoelectric Point: 8.1124
>AT10010 YP_863932.1 NC_007145:c8828-8355 [Burkholderia phage phiE52237]
MTISALQLAAELIRRSDAQSRPQFTTNLAIQKLAYFCHGWHLALSGEPLVNEPFEAWRFGPVLPGLYHTLKVFSSNPIPA
NHPLVISQASLPAGSWSGQLIDHVLNVYGGLSTTQLVSISHASDGPWQQVWSQGPSSWITNESIATYFRKLANKPAQ
MTISALQLAAELIRRSDAQSRPQFTTNLAIQKLAYFCHGWHLALSGEPLVNEPFEAWRFGPVLPGLYHTLKVFSSNPIPA
NHPLVISQASLPAGSWSGQLIDHVLNVYGGLSTTQLVSISHASDGPWQQVWSQGPSSWITNESIATYFRKLANKPAQ
Download Length: 474 bp
>AT10010 NC_007145:c8828-8355 [Burkholderia phage phiE52237]
ATGACGATATCTGCGCTCCAACTCGCCGCCGAGTTGATTCGCCGGTCTGATGCCCAAAGCCGGCCCCAATTTACGACGAA
CCTTGCCATCCAGAAGCTCGCCTACTTCTGCCATGGGTGGCATCTTGCGCTGTCTGGCGAGCCGCTCGTGAACGAACCAT
TCGAAGCATGGCGGTTCGGCCCCGTTTTGCCAGGGCTGTATCACACGCTGAAGGTTTTTTCGTCGAATCCGATACCAGCC
AATCACCCTCTTGTAATCAGCCAAGCATCCCTTCCCGCGGGAAGCTGGAGCGGCCAGTTGATTGACCACGTCCTGAATGT
CTATGGTGGCCTGAGTACTACCCAACTTGTTTCCATTTCACATGCAAGTGATGGACCATGGCAACAAGTCTGGAGCCAAG
GGCCAAGTTCATGGATTACTAACGAATCAATTGCGACGTACTTCCGCAAGCTTGCAAACAAGCCGGCCCAATAA
ATGACGATATCTGCGCTCCAACTCGCCGCCGAGTTGATTCGCCGGTCTGATGCCCAAAGCCGGCCCCAATTTACGACGAA
CCTTGCCATCCAGAAGCTCGCCTACTTCTGCCATGGGTGGCATCTTGCGCTGTCTGGCGAGCCGCTCGTGAACGAACCAT
TCGAAGCATGGCGGTTCGGCCCCGTTTTGCCAGGGCTGTATCACACGCTGAAGGTTTTTTCGTCGAATCCGATACCAGCC
AATCACCCTCTTGTAATCAGCCAAGCATCCCTTCCCGCGGGAAGCTGGAGCGGCCAGTTGATTGACCACGTCCTGAATGT
CTATGGTGGCCTGAGTACTACCCAACTTGTTTCCATTTCACATGCAAGTGATGGACCATGGCAACAAGTCTGGAGCCAAG
GGCCAAGTTCATGGATTACTAACGAATCAATTGCGACGTACTTCCGCAAGCTTGCAAACAAGCCGGCCCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT6367 | Caulobacter crescentus NA1000 |
36.31 |
100 |
0.389 |
| AT10007 | Escherichia coli STEC_O31 |
31.818 |
98.089 |
0.312 |
| AT10013 | Vibrio harveyi strain FDAARGOS_107 |
31.579 |
98.065 |
0.31 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Tatsuaki Kurata et al. (2022) A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains. Proceedings of The National Academy of Sciences of The United States of America 119(6):e2102212119. [PubMed:35121656]