Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type VI Classification (family/domain) socAB/-
Location 3785533..3786790 Replicon chromosome
Accession NC_011916
Organism Caulobacter crescentus NA1000

Toxin (Protein)


Gene name socB Uniprot ID A0A0H3CC30
Locus tag CCNA_03629 Protein ID YP_002519002.1
Coordinates 3785533..3786246 (-) Length 238 a.a.

Antitoxin (Protein)


Gene name socA Uniprot ID A0A0H3CCP8
Locus tag CCNA_03630 Protein ID YP_002519003.1
Coordinates 3786224..3786790 (-) Length 189 a.a.

Genomic Context

CCNA_03631CCNA_03632CCNA_03633CCNA_03626CCNA_03627CCNA_03628CCNA_03629CCNA_03630CCNA_03634CCNA_03996CCNA_03635CCNA_03636
Location: 3786985..3787089 (105 bp)
Type: Others
Protein ID: YP_002519004.1
Location: 3787137..3787517 (381 bp)
Type: Others
Protein ID: YP_002519005.1
Location: 3787860..3788231 (372 bp)
Type: Others
Protein ID: YP_002519006.1
Location: 3781650..3782612 (963 bp)
Type: Others
Protein ID: YP_002518999.1
Location: 3782612..3783772 (1161 bp)
Type: Others
Protein ID: YP_002519000.3
Location: 3783744..3785231 (1488 bp)
Type: Others
Protein ID: YP_002519001.1
Location: 3785533..3786246 (714 bp)
Type: Toxin
Protein ID: YP_002519002.1
Location: 3786224..3786790 (567 bp)
Type: Antitoxin
Protein ID: YP_002519003.1
Location: 3788397..3788990 (594 bp)
Type: Others
Protein ID: YP_002519007.1
Location: 3789044..3789103 (60 bp)
Type: Others
Protein ID: YP_009020568.1
Location: 3789100..3789477 (378 bp)
Type: Others
Protein ID: YP_002519008.1
Location: 3789689..3790714 (1026 bp)
Type: Others
Protein ID: YP_002519009.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CCNA_036263781650..3782612-963YP_002518999.1ATP phosphoribosyltransferase-
CCNA_036273782612..3783772-1161YP_002519000.3ATP phosphoribosyltransferase regulatory subunit-
CCNA_036283783744..3785231-1488YP_002519001.1histidyl-tRNA synthetase-
CCNA_036293785533..3786246-714YP_002519002.1DNA replication inhibitor toxin SocBToxin
CCNA_036303786224..3786790-567YP_002519003.1antitoxin protein SocAAntitoxin
CCNA_036313786985..3787089+105YP_002519004.1hypothetical protein-
CCNA_036323787137..3787517+381YP_002519005.1hypothetical protein-
CCNA_036333787860..3788231+372YP_002519006.1GIY-YIG domain protein-
CCNA_036343788397..3788990-594YP_002519007.1DoxX family protein-
CCNA_039963789044..3789103-60YP_009020568.1hypothetical protein-
CCNA_036353789100..3789477-378YP_002519008.1hypothetical protein-
CCNA_036363789689..3790714-1026YP_002519009.1biotin synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(36-140)


Sequences

Toxin        


Download         Length: 238 a.a.        Molecular weight: 27110.66 Da        Isoelectric Point: 6.7466

>T6367 YP_002519002.1 NC_011916:c3786246-3785533 [Caulobacter vibrioides NA1000]
MKKHRLPDTELARIAPLAPDARRKALLKFKNGFPDFSYEPTRRRLPELTNAQPSLLSLGDTEWSKIESGLKRLKNEKEAA
SNIEVAELLYNFIREEKYIAVMEPFGKLQLGAGVAISYWSDAIFFGPDGPTIFGFDFRRAGGFNDSARRFAFSAQHEHIR
QRGDDYATAKLGLVQFPALRNGTRKVRVEFADQVELIPYDELIQMARETYSVWFEILEQREDEARKTGTGGSWWDGD

Download         Length: 714 bp

>T6367 NC_011916:c3786246-3785533 [Caulobacter vibrioides NA1000]
TTGAAGAAGCACCGCCTTCCTGACACGGAACTGGCCCGTATTGCTCCCTTGGCGCCTGATGCTAGGCGCAAAGCGCTATT
GAAATTCAAGAATGGGTTTCCCGATTTCTCTTATGAGCCCACGCGACGTCGTCTGCCTGAGCTGACCAACGCCCAGCCCT
CCCTCCTGTCGCTTGGAGATACTGAGTGGAGTAAGATCGAGAGCGGCCTGAAAAGGCTCAAAAATGAGAAAGAGGCCGCC
TCAAATATAGAGGTCGCCGAGCTGCTGTATAATTTTATCAGAGAAGAAAAATACATCGCTGTCATGGAGCCATTTGGAAA
GCTCCAACTTGGTGCTGGCGTGGCGATATCATATTGGTCGGACGCGATTTTCTTTGGGCCAGATGGGCCAACGATATTCG
GCTTCGACTTTCGTCGGGCCGGAGGCTTTAACGATTCTGCTCGCCGCTTTGCTTTCTCTGCCCAGCACGAACATATTCGT
CAGAGAGGTGACGACTATGCCACCGCGAAACTCGGCTTGGTCCAATTTCCGGCGTTGCGAAATGGCACTAGAAAAGTGCG
TGTCGAGTTCGCGGATCAGGTCGAACTAATTCCGTACGATGAGCTGATCCAGATGGCCCGCGAGACGTACAGCGTTTGGT
TTGAAATCCTCGAACAGCGTGAGGATGAGGCCCGCAAGACGGGTACCGGTGGTTCCTGGTGGGATGGTGATTGA

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20423.76 Da        Isoelectric Point: 9.5400

>AT6367 YP_002519003.1 NC_011916:c3786790-3786224 [Caulobacter vibrioides NA1000]
MPPLTQDPQSVDARAVANLLLDKAAALDIPISNLALQKLLYFAHGRFLVDKGRPLVNGFFEAWKFGPVHPVVYRCFSANG
PKYIINRAIKKDILSGLHIIVSPPRDQDIHEGIERVLLTMGRMSASQLVAVSHASGGPWDVIANGPGTNLGLGLRICDKV
IKDRFRFQKVSVSVPPGLGDTLEEAPPS

Download         Length: 567 bp

>AT6367 NC_011916:c3786790-3786224 [Caulobacter vibrioides NA1000]
ATGCCTCCGCTGACTCAAGACCCTCAGTCGGTTGACGCGCGCGCAGTTGCCAACCTGCTCCTCGATAAGGCTGCGGCGCT
AGACATTCCGATAAGCAACCTAGCGCTCCAAAAGCTTCTTTACTTCGCGCACGGTCGCTTTCTTGTGGATAAAGGGCGCC
CCCTTGTAAACGGATTTTTCGAGGCTTGGAAATTCGGGCCAGTTCACCCTGTGGTTTATAGGTGCTTTAGTGCGAACGGA
CCTAAGTATATAATCAATAGAGCGATTAAGAAAGACATCCTGTCGGGCCTTCATATTATTGTATCTCCACCTCGTGACCA
GGATATTCATGAGGGCATCGAGCGTGTGCTGTTAACGATGGGGAGGATGTCTGCCTCTCAACTGGTCGCCGTCTCGCACG
CGTCTGGTGGTCCCTGGGACGTCATTGCGAACGGACCGGGAACAAATCTTGGGCTTGGGCTGCGGATATGCGATAAGGTG
ATCAAGGATCGATTCCGATTCCAGAAAGTCTCCGTAAGCGTTCCCCCCGGCCTTGGAGATACCCTTGAAGAAGCACCGCC
TTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT10010Burkholderia prophage phi52237

36.31

100

0.389

AT10013Vibrio harveyi strain FDAARGOS_107

34.307

88.387

0.303
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3CC30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3CCP8

References

(1) Christopher D Aakre et al. (2013) A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp. Molecular Cell 52(5):617-28. [PubMed:24239291] experimental


experimental experimental literature