MGE detailed information

MGE type: Conjugative plasmid        MGE length: 143980 bp
Accession: NZ_CP085890        Location: 1..143980         Organism: Klebsiella pneumoniae strain 8695       Replicon: plasmid pFK8695-KPC-33


Gene structure


The 5 kb flanking regions of this MGE are displayed.

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKW25_RS27085 (1) 1..402 + 402 WP_002027369.1 Tn3 family transposase TnpR_Tn3 Transposase
LKW25_RS27090 (525) 525..1505 + 981 WP_013213985.1 IS481 family transposase ISKpn27 Transposase
LKW25_RS27095 (1781) 1781..2662 + 882 WP_101140102.1 Carbapenem-hydrolyzing beta-lactamase KPC ARG
LKW25_RS27100 (2912) 2912..3793 - 882 Protein_3 IS1182 family transposase ISKpn6 Transposase
LKW25_RS27105 (3897) 3897..4193 - 297 WP_013213987.1 transcriptional regulator -
LKW25_RS27110 (4239) 4239..4394 - 156 WP_013213988.1 hypothetical protein -
LKW25_RS27115 (4522) 4522..4947 - 426 WP_013213989.1 antirestriction protein -
LKW25_RS27120 (5058) 5058..5336 - 279 WP_013213990.1 hypothetical protein -
LKW25_RS27125 (5870) 5870..6487 - 618 Protein_8 replication protein -
LKW25_RS27130 (6879) 6879..7439 + 561 WP_001161490.1 Tn3 family transposase TnpR_TnAs1 Transposase
LKW25_RS27135 (7443) 7443..10409 + 2967 WP_001138014.1 Tn3 family transposase TnpA_TnAs1 Transposase
LKW25_RS27140 (10445) 10445..10513 - 69 Protein_11 IS6 family transposase -
LKW25_RS27145 (10650) 10650..11511 + 862 Protein_12 Beta-lactamase SHV-2 ARG
LKW25_RS27150 (11532) 11532..12293 - 762 WP_002210513.1 DeoR/GlpR family DNA-binding transcription regulator -
LKW25_RS27155 (12555) 12555..13457 + 903 WP_002903955.1 NAD(P)-dependent oxidoreductase -
LKW25_RS27160 (13469) 13469..14721 + 1253 Protein_15 four-carbon acid sugar kinase family protein -
LKW25_RS27165 (14714) 14714..15037 + 324 Protein_16 class II aldolase/adducin family protein -
LKW25_RS27170 (15091) 15091..15795 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
LKW25_RS27175 (15861) 15861..16139 + 279 Protein_18 chemotaxis protein -
LKW25_RS27180 (16213) 16213..16917 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase
LKW25_RS27185 (17138) 17138..17611 + 474 Protein_20 replication initiation protein -
LKW25_RS27190 (17679) 17679..18659 + 981 WP_000019473.1 IS5 family transposase ISKpn26 Transposase
LKW25_RS27195 (18641) 18641..19204 + 564 WP_228015052.1 replication initiation protein -
LKW25_RS27200 (20314) 20314..21519 + 1206 WP_011977818.1 AAA family ATPase -
LKW25_RS27205 (21519) 21519..22493 + 975 WP_011977819.1 ParB family protein -
LKW25_RS27210 (22575) 22575..23846 - 1272 WP_013214011.1 Y-family DNA polymerase -
LKW25_RS27215 (23846) 23846..24277 - 432 WP_001568036.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LKW25_RS27220 (24684) 24684..26172 + 1489 Protein_27 group II intron reverse transcriptase/maturase -
LKW25_RS27225 (26421) 26421..27392 + 972 WP_004152353.1 plasmid segregation protein ParM -
LKW25_RS27230 (27395) 27395..28066 + 672 WP_013214012.1 plasmid partitioning/stability family protein -
LKW25_RS27235 (28129) 28129..28359 + 231 WP_001568040.1 hypothetical protein -
LKW25_RS27240 (28555) 28555..28724 + 170 Protein_31 hypothetical protein -
LKW25_RS27245 (28796) 28796..29497 + 702 WP_001568041.1 DNA methylase -
LKW25_RS27250 (29497) 29497..29718 + 222 WP_001568042.1 hypothetical protein -
LKW25_RS27255 (29728) 29728..30147 + 420 WP_001568043.1 DUF1380 domain-containing protein -
LKW25_RS27260 (30201) 30201..30968 + 768 WP_013214013.1 hypothetical protein -
LKW25_RS27265 (31649) 31649..32077 + 429 WP_001568045.1 antirestriction protein -
LKW25_RS27270 (32120) 32120..32626 + 507 WP_013214014.1 antirestriction protein ArdA -
LKW25_RS27275 (32669) 32669..32860 + 192 WP_001568047.1 hypothetical protein -
LKW25_RS27280 (33048) 33048..33302 + 255 WP_011977779.1 DNA polymerase III subunit theta -
LKW25_RS27285 (33337) 33337..33657 + 321 WP_001568049.1 hypothetical protein -
LKW25_RS27290 (34337) 34337..34564 + 228 WP_001568050.1 hypothetical protein -
LKW25_RS27295 (34656) 34656..34886 + 231 WP_001568051.1 hypothetical protein -
LKW25_RS27300 (34938) 34938..36293 + 1356 WP_014343515.1 DUF3560 domain-containing protein -
LKW25_RS27305 (36341) 36341..36904 + 564 WP_014343514.1 methyltransferase -
LKW25_RS27310 (37737) 37737..38279 + 543 WP_014343512.1 single-stranded DNA-binding protein -
LKW25_RS27315 (38328) 38328..38576 + 249 WP_001568055.1 DUF905 domain-containing protein -
LKW25_RS27320 (38646) 38646..40703 + 2058 WP_015493064.1 ParB/RepB/Spo0J family partition protein -
LKW25_RS27325 (40748) 40748..41179 + 432 WP_001568057.1 conjugation system SOS inhibitor PsiB -
LKW25_RS27330 (41176) 41176..41904 + 729 WP_001568058.1 plasmid SOS inhibition protein A -
LKW25_RS27335 (41901) 41901..42227 + 327 WP_013023807.1 hypothetical protein -
LKW25_RS27340 (42283) 42283..42657 + 375 WP_014343510.1 hypothetical protein -
LKW25_RS27345 (42827) 42827..42976 + 150 Protein_52 DUF5431 family protein -
LKW25_RS27350 (42927) 42927..43043 + 117 WP_055313929.1 type I toxin-antitoxin system Hok family toxin -
LKW25_RS27355 (43736) 43736..44008 + 273 WP_040245921.1 hypothetical protein -
LKW25_RS27360 (44005) 44005..44355 + 351 WP_040245917.1 hypothetical protein -
LKW25_RS27365 (44370) 44370..44687 + 318 WP_014343505.1 hypothetical protein -
LKW25_RS27370 (45528) 45528..45884 + 357 WP_014343501.1 hypothetical protein -
LKW25_RS27375 (45945) 45945..46157 + 213 WP_014343500.1 hypothetical protein -
LKW25_RS27380 (46168) 46168..46392 + 225 WP_014343499.1 hypothetical protein -
LKW25_RS27385 (46473) 46473..46793 + 321 WP_014343498.1 type II toxin-antitoxin system RelE/ParE family toxin -
LKW25_RS27390 (46783) 46783..47061 + 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
LKW25_RS27395 (47065) 47065..47169 + 105 Protein_62 transcriptional regulator -
LKW25_RS27400 (47998) 47998..48819 + 822 WP_004152492.1 DUF932 domain-containing protein -
LKW25_RS27405 (48852) 48852..49181 + 330 WP_013214015.1 DUF5983 family protein -
LKW25_RS27410 (49214) 49214..49699 - 486 WP_014343495.1 hypothetical protein VF
LKW25_RS27415 (50090) 50090..50506 + 417 WP_014343494.1 conjugal transfer relaxosome DNA-binding protein TraM -
LKW25_RS27420 (50706) 50706..51443 + 738 WP_154244330.1 conjugal transfer protein TrbJ -
LKW25_RS27425 (51558) 51558..51764 + 207 WP_171773970.1 TraY domain-containing protein -
LKW25_RS27430 (51826) 51826..52194 + 369 WP_004194426.1 type IV conjugative transfer system pilin TraA -
LKW25_RS27435 (52208) 52208..52513 + 306 WP_004144424.1 type IV conjugative transfer system protein TraL -
LKW25_RS27440 (52533) 52533..52898 + 366 Protein_71 type IV conjugative transfer system protein TraE -
LKW25_RS27445 (52953) 52953..53297 - 345 Protein_72 IS6 family transposase IS26 Transposase
LKW25_RS27450 (53349) 53349..54053 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
LKW25_RS27455 (54078) 54078..54278 + 201 WP_072354025.1 hypothetical protein -
LKW25_RS27460 (54298) 54298..55044 + 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
LKW25_RS27465 (55099) 55099..55659 + 561 WP_000139328.1 fertility inhibition protein FinO -
LKW25_RS27470 (55791) 55791..55991 + 201 WP_015059022.1 hypothetical protein -
LKW25_RS27475 (56377) 56377..56976 + 600 WP_032083981.1 PIN domain-containing protein -
LKW25_RS27480 (57038) 57038..57370 + 333 WP_152916585.1 hypothetical protein -
- (57571) 57571..57630 - 60 NuclAT_1 - Antitoxin Detail
- (57571) 57571..57630 - 60 NuclAT_1 - Antitoxin Detail
- (57571) 57571..57630 - 60 NuclAT_1 - Antitoxin Detail
- (57571) 57571..57630 - 60 NuclAT_1 - Antitoxin Detail
LKW25_RS27485 (57675) 57675..57824 + 150 WP_001312851.1 Hok/Gef family protein Toxin Detail
LKW25_RS27490 (58108) 58108..58356 + 249 WP_000083837.1 replication regulatory protein RepA -
LKW25_RS27495 (58471) 58471..58649 + 179 Protein_82 protein CopA/IncA -
LKW25_RS27505 (58668) 58668..59525 + 858 WP_032495102.1 incFII family plasmid replication initiator RepA -
LKW25_RS27510 (60464) 60464..61117 + 654 WP_000616807.1 CPBP family intramembrane metalloprotease -
LKW25_RS27515 (61210) 61210..61467 + 258 WP_000557619.1 type II toxin-antitoxin system antitoxin PemI -
LKW25_RS27520 (61400) 61400..61801 + 402 WP_001398199.1 type II toxin-antitoxin system toxin endoribonuclease PemK -
LKW25_RS27525 (62050) 62050..62465 + 416 Protein_87 IS1-like element IS1B family transposase -
LKW25_RS27530 (62501) 62501..63046 - 546 Protein_88 Tn3 family transposase TnpA_Tn3 Transposase
LKW25_RS27535 (63112) 63112..63817 - 706 Protein_89 IS6-like element IS26 family transposase -
LKW25_RS27540 (63887) 63887..64078 + 192 Protein_90 IS1380 family transposase -
LKW25_RS27545 (64328) 64328..65203 + 876 WP_013188475.1 Beta-lactamase Toho-1 ARG
LKW25_RS27550 (65238) 65238..66206 + 969 WP_013362812.1 IS5 family transposase IS903B Transposase
LKW25_RS27555 (66263) 66263..67360 + 1098 Protein_93 TonB-dependent receptor -
LKW25_RS27560 (67428) 67428..67904 - 477 Protein_94 PAS domain-containing protein -
LKW25_RS27565 (67957) 67957..68427 - 471 Protein_95 IS6 family transposase IS26 Transposase
LKW25_RS27570 (68482) 68482..69186 - 705 WP_001067858.1 IS6 family transposase IS15DI Transposase
LKW25_RS27580 (70766) 70766..71000 + 235 Protein_97 type II toxin-antitoxin system RelE/ParE family toxin -
LKW25_RS27585 (71128) 71128..71409 + 282 WP_001333089.1 hypothetical protein -
LKW25_RS27590 (71532) 71532..71882 - 351 WP_000361389.1 plasmid partitioning/stability family protein -
LKW25_RS27595 (71885) 71885..72847 - 963 WP_000959884.1 plasmid segregation protein ParM -
LKW25_RS27600 (72994) 72994..73287 + 294 WP_032146011.1 hypothetical protein -
LKW25_RS27605 (73364) 73364..74047 + 684 WP_000085883.1 DNA methylase -
LKW25_RS27610 (74048) 74048..74269 + 222 WP_001104881.1 hypothetical protein -
LKW25_RS27615 (74283) 74283..74717 + 435 WP_000274503.1 DUF1380 family protein -
LKW25_RS27620 (74768) 74768..75544 + 777 WP_001383963.1 hypothetical protein -
LKW25_RS27625 (75962) 75962..76387 + 426 WP_001198928.1 antirestriction protein -
LKW25_RS27630 (76434) 76434..76856 + 423 WP_000271762.1 DUF1380 family protein -
LKW25_RS27635 (76853) 76853..77044 + 192 WP_001027493.1 hypothetical protein -
LKW25_RS27640 (77358) 77358..79025 - 1668 WP_012372796.1 group II intron reverse transcriptase/maturase -
LKW25_RS27645 (79754) 79754..79908 - 155 Protein_110 hypothetical protein -
LKW25_RS27650 (80425) 80425..80655 + 231 WP_000218642.1 hypothetical protein -
LKW25_RS27655 (80707) 80707..82068 + 1362 WP_000170695.1 DUF3560 domain-containing protein -
LKW25_RS27660 (82115) 82115..82678 + 564 WP_015059007.1 class I SAM-dependent methyltransferase -
LKW25_RS27665 (82764) 82764..83231 - 468 Protein_114 hypothetical protein -
LKW25_RS27670 (83533) 83533..84060 + 528 WP_000290834.1 single-stranded DNA-binding protein -
LKW25_RS27675 (84118) 84118..84351 + 234 WP_000006003.1 DUF905 family protein -
LKW25_RS27680 (84412) 84412..86435 + 2024 Protein_117 ParB/RepB/Spo0J family partition protein -
LKW25_RS27685 (86504) 86504..86938 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
LKW25_RS27690 (86935) 86935..87654 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- (87666) 87666..87890 + 225 NuclAT_0 - -
- (87666) 87666..87890 + 225 NuclAT_0 - -
- (87666) 87666..87890 + 225 NuclAT_0 - -
- (87666) 87666..87890 + 225 NuclAT_0 - -
LKW25_RS27695 (87876) 87876..88025 + 150 Protein_120 plasmid maintenance protein Mok -
LKW25_RS27700 (87967) 87967..88092 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin Detail
LKW25_RS27705 (88411) 88411..88707 - 297 Protein_122 hypothetical protein -
LKW25_RS27710 (89007) 89007..89303 + 297 WP_001272251.1 hypothetical protein -
LKW25_RS27715 (89414) 89414..90235 + 822 WP_001234445.1 DUF932 domain-containing protein -
LKW25_RS27720 (90532) 90532..91179 - 648 WP_015059008.1 hypothetical protein VF
LKW25_RS27725 (91456) 91456..91839 + 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
LKW25_RS27730 (92030) 92030..92716 + 687 WP_015059009.1 PAS domain-containing protein -
LKW25_RS27735 (92810) 92810..93037 + 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -
LKW25_RS27740 (93071) 93071..93436 + 366 WP_021519752.1 type IV conjugative transfer system pilin TraA -
LKW25_RS27745 (93451) 93451..93762 + 312 WP_000012106.1 type IV conjugative transfer system protein TraL -
LKW25_RS27750 (93784) 93784..94350 + 567 WP_000399794.1 type IV conjugative transfer system protein TraE -
LKW25_RS27755 (94337) 94337..95065 + 729 WP_001230787.1 type-F conjugative transfer system secretin TraK -
LKW25_RS27760 (95065) 95065..96492 + 1428 WP_032297072.1 F-type conjugal transfer pilus assembly protein TraB -
LKW25_RS27765 (96482) 96482..97072 + 591 WP_000002778.1 conjugal transfer pilus-stabilizing protein TraP -
LKW25_RS27770 (97059) 97059..97256 + 198 WP_001324648.1 conjugal transfer protein TrbD -
LKW25_RS27775 (97268) 97268..97519 + 252 WP_001038341.1 conjugal transfer protein TrbG -
LKW25_RS27780 (97516) 97516..98031 + 516 WP_062955122.1 type IV conjugative transfer system lipoprotein TraV -
LKW25_RS27785 (98166) 98166..98387 + 222 WP_001278692.1 conjugal transfer protein TraR -
LKW25_RS27790 (98547) 98547..101174 + 2628 WP_015059012.1 type IV secretion system protein TraC -
LKW25_RS27795 (101171) 101171..101557 + 387 WP_015059013.1 type-F conjugative transfer system protein TrbI -
LKW25_RS27800 (101554) 101554..102186 + 633 WP_001203735.1 type-F conjugative transfer system protein TraW -
LKW25_RS27805 (102183) 102183..103175 + 993 WP_000830838.1 conjugal transfer pilus assembly protein TraU -
LKW25_RS27810 (103202) 103202..103510 + 309 WP_000412447.1 hypothetical protein -
LKW25_RS27815 (103573) 103573..104094 + 522 WP_015059014.1 hypothetical protein -
LKW25_RS27820 (104121) 104121..104759 + 639 WP_000087532.1 type-F conjugative transfer system pilin assembly protein TrbC -
LKW25_RS27825 (104756) 104756..105127 + 372 WP_000056336.1 hypothetical protein -
LKW25_RS27830 (105153) 105153..105575 + 423 WP_001229309.1 HNH endonuclease signature motif containing protein -
LKW25_RS27835 (105572) 105572..107422 + 1851 WP_015059015.1 type-F conjugative transfer system mating-pair stabilization protein TraN -
LKW25_RS27840 (107449) 107449..107706 + 258 WP_053913405.1 conjugal transfer protein TrbE -
LKW25_RS27845 (107693) 107693..108442 + 750 WP_072354014.1 type-F conjugative transfer system pilin assembly protein TraF -
LKW25_RS27850 (108603) 108603..108839 + 237 WP_000270010.1 type-F conjugative transfer system pilin chaperone TraQ -
LKW25_RS27855 (108826) 108826..109371 + 546 WP_000059817.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
LKW25_RS27860 (109361) 109361..109675 + 315 WP_001384255.1 P-type conjugative transfer protein TrbJ -
LKW25_RS27865 (109629) 109629..110021 + 393 WP_000126338.1 F-type conjugal transfer protein TrbF -
LKW25_RS27870 (110008) 110008..111381 + 1374 WP_000944325.1 conjugal transfer pilus assembly protein TraH -
LKW25_RS27875 (111378) 111378..114194 + 2817 WP_015059018.1 conjugal transfer mating-pair stabilization protein TraG -
LKW25_RS27880 (114227) 114227..114748 + 522 WP_000632668.1 conjugal transfer entry exclusion protein TraS -
LKW25_RS27885 (114773) 114773..115504 + 732 WP_021559024.1 conjugal transfer complement resistance protein TraT -
LKW25_RS27890 (115707) 115707..116444 + 738 WP_015059020.1 hypothetical protein -
LKW25_RS27895 (116495) 116495..118711 + 2217 WP_059274178.1 type IV conjugative transfer system coupling protein TraD -
LKW25_RS27900 (118711) 118711..123765 + 5055 WP_228015050.1 Multifunctional conjugation protein TraI Relaxase
LKW25_RS27905 (123711) 123711..124415 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
LKW25_RS27910 (124479) 124479..124763 - 285 Protein_163 PAS domain-containing protein -
LKW25_RS27915 (124829) 124829..125533 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase
LKW25_RS27920 (125961) 125961..126074 + 114 WP_014343462.1 hypothetical protein -
LKW25_RS27925 (126203) 126203..126460 + 258 WP_013214010.1 hypothetical protein -
LKW25_RS27930 (126506) 126506..127285 - 780 WP_013214009.1 site-specific integrase -
LKW25_RS27935 (127469) 127469..128473 - 1005 WP_011977814.1 hypothetical protein -
LKW25_RS27940 (128503) 128503..128706 - 204 WP_011977813.1 hypothetical protein -
LKW25_RS27945 (128752) 128752..129273 - 522 WP_013214008.1 hypothetical protein -
LKW25_RS27950 (129331) 129331..129723 - 393 WP_011977811.1 hypothetical protein -
LKW25_RS27955 (129760) 129760..130704 - 945 WP_011977810.1 hypothetical protein -
LKW25_RS27960 (130865) 130865..131326 - 462 WP_014343465.1 hypothetical protein -
LKW25_RS27965 (131283) 131283..131513 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin -
LKW25_RS27970 (131510) 131510..131926 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin Detail
LKW25_RS27975 (132000) 132000..133562 + 1563 WP_004206609.1 AAA family ATPase -
LKW25_RS27980 (133547) 133547..134569 + 1023 WP_000361404.1 helicase UvrD -
LKW25_RS27985 (134825) 134825..135522 + 698 WP_223174630.1 IS1 family transposase ISKpn14 Transposase
LKW25_RS27990 (135551) 135551..135823 + 273 Protein_179 IS5 family transposase ISPan1 Transposase
LKW25_RS27995 (136103) 136103..137108 - 1006 Protein_180 IS110 family transposase IS4321 Transposase
LKW25_RS28000 (137187) 137187..137621 - 435 WP_000429836.1 IS607 family transposase ISChh1 Transposase
LKW25_RS28005 (137693) 137693..138043 + 351 WP_001294663.1 mercuric transport protein MerT -
LKW25_RS28010 (138057) 138057..138332 + 276 WP_000732292.1 mercury resistance system periplasmic binding protein MerP -
LKW25_RS28015 (138368) 138368..138790 + 423 WP_001340589.1 organomercurial transporter MerC -
LKW25_RS28020 (138842) 138842..140536 + 1695 WP_000105636.1 mercury(II) reductase -
LKW25_RS28025 (140554) 140554..140916 + 363 WP_001277456.1 mercury resistance co-regulator MerD -
LKW25_RS28030 (140913) 140913..141149 + 237 WP_000993386.1 broad-spectrum mercury transporter MerE -
LKW25_RS28035 (141185) 141185..141853 + 669 WP_001300294.1 putative signaling protein VF
LKW25_RS28040 (141928) 141928..143100 + 1173 Protein_189 transposase -
LKW25_RS28045 (143165) 143165..143869 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase

Similar MGE(s)


Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.

Detail Organism MGE type Related TA Genome accession Coordinates Mash
distance