MGE detailed information
MGE type: Mobilizable plasmid MGE length: 123686 bp
Accession: NZ_CP076554 Location: 1..123686 Organism: Klebsiella pneumoniae strain 19PDR22 Replicon: plasmid p19PDR22-KPC4
Accession: NZ_CP076554 Location: 1..123686 Organism: Klebsiella pneumoniae strain 19PDR22 Replicon: plasmid p19PDR22-KPC4
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HF574_RS29430 (1) | 1..858 | + | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
| HF574_RS29435 (1797) | 1797..2450 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| HF574_RS29440 (2543) | 2543..2800 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| HF574_RS29445 (2733) | 2733..3134 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| HF574_RS29450 (3383) | 3383..3798 | + | 416 | Protein_4 | IS1 family transposase IS1R | Transposase |
| HF574_RS29455 (3834) | 3834..4379 | - | 546 | Protein_5 | Tn3 family transposase TnpA_Tn3 | Transposase |
| HF574_RS29460 (4445) | 4445..5149 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29465 (5219) | 5219..5410 | + | 192 | Protein_7 | IS1380 family transposase | - |
| HF574_RS29470 (5660) | 5660..6535 | + | 876 | WP_013188475.1 | Beta-lactamase Toho-1 | ARG |
| HF574_RS29475 (6570) | 6570..7538 | + | 969 | WP_013362812.1 | IS5 family transposase IS903B | Transposase |
| HF574_RS29480 (7595) | 7595..8692 | + | 1098 | Protein_10 | TonB-dependent receptor | - |
| HF574_RS29485 (8760) | 8760..9236 | - | 477 | Protein_11 | PAS domain-containing protein | - |
| HF574_RS29490 (9289) | 9289..9993 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29495 (10059) | 10059..10124 | + | 66 | Protein_13 | IS1 family transposase | - |
| HF574_RS29500 (11573) | 11573..11807 | + | 235 | Protein_14 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HF574_RS29505 (11935) | 11935..12216 | + | 282 | WP_001333089.1 | hypothetical protein | - |
| HF574_RS29510 (12339) | 12339..12689 | - | 351 | WP_000361389.1 | plasmid partitioning/stability family protein | - |
| HF574_RS29515 (12692) | 12692..13654 | - | 963 | WP_000959884.1 | plasmid segregation protein ParM | - |
| HF574_RS29520 (13801) | 13801..14094 | + | 294 | WP_032146011.1 | hypothetical protein | - |
| HF574_RS29525 (14171) | 14171..14854 | + | 684 | WP_000085883.1 | DNA methylase | - |
| HF574_RS29530 (14855) | 14855..15076 | + | 222 | WP_001104881.1 | hypothetical protein | - |
| HF574_RS29535 (15090) | 15090..15524 | + | 435 | WP_000274503.1 | DUF1380 family protein | - |
| HF574_RS29540 (15575) | 15575..16351 | + | 777 | WP_001383963.1 | hypothetical protein | - |
| HF574_RS29545 (16769) | 16769..17194 | + | 426 | WP_001198928.1 | antirestriction protein | - |
| HF574_RS29550 (17241) | 17241..17663 | + | 423 | WP_000271762.1 | DUF1380 family protein | - |
| HF574_RS29555 (17660) | 17660..17851 | + | 192 | WP_001027493.1 | hypothetical protein | - |
| HF574_RS29560 (18165) | 18165..19832 | - | 1668 | WP_012372796.1 | group II intron reverse transcriptase/maturase | - |
| HF574_RS30525 (20561) | 20561..20715 | - | 155 | Protein_27 | hypothetical protein | - |
| HF574_RS29565 (21232) | 21232..21462 | + | 231 | WP_000218642.1 | hypothetical protein | - |
| HF574_RS29570 (21514) | 21514..22875 | + | 1362 | WP_000170695.1 | DUF3560 domain-containing protein | - |
| HF574_RS29575 (22922) | 22922..23485 | + | 564 | WP_015059007.1 | class I SAM-dependent methyltransferase | - |
| HF574_RS30530 (23571) | 23571..24026 | - | 456 | Protein_31 | hypothetical protein | - |
| HF574_RS29580 (24328) | 24328..24855 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
| HF574_RS29585 (24913) | 24913..25146 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
| HF574_RS29590 (25207) | 25207..27230 | + | 2024 | Protein_34 | ParB/RepB/Spo0J family partition protein | - |
| HF574_RS29595 (27299) | 27299..27733 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| HF574_RS29600 (27730) | 27730..28449 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
| - (28461) | 28461..28685 | + | 225 | NuclAT_0 | - | - |
| - (28461) | 28461..28685 | + | 225 | NuclAT_0 | - | - |
| - (28461) | 28461..28685 | + | 225 | NuclAT_0 | - | - |
| - (28461) | 28461..28685 | + | 225 | NuclAT_0 | - | - |
| HF574_RS30535 (28671) | 28671..28820 | + | 150 | Protein_37 | plasmid maintenance protein Mok | - |
| HF574_RS29605 (28762) | 28762..28887 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| HF574_RS29610 (29206) | 29206..29502 | - | 297 | Protein_39 | hypothetical protein | - |
| HF574_RS29615 (29802) | 29802..30098 | + | 297 | WP_001272251.1 | hypothetical protein | - |
| HF574_RS29620 (30209) | 30209..31030 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
| HF574_RS29625 (31327) | 31327..31974 | - | 648 | WP_015059008.1 | hypothetical protein | VF |
| HF574_RS29630 (32251) | 32251..32634 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| HF574_RS29635 (32825) | 32825..33511 | + | 687 | WP_015059009.1 | PAS domain-containing protein | - |
| HF574_RS29640 (33605) | 33605..33832 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
| HF574_RS29645 (33866) | 33866..34231 | + | 366 | WP_216833413.1 | type IV conjugative transfer system pilin TraA | - |
| HF574_RS29650 (34246) | 34246..34557 | + | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| HF574_RS29655 (34579) | 34579..35145 | + | 567 | WP_000399794.1 | type IV conjugative transfer system protein TraE | - |
| HF574_RS29660 (35132) | 35132..35860 | + | 729 | WP_001230787.1 | type-F conjugative transfer system secretin TraK | - |
| HF574_RS29665 (35860) | 35860..37287 | + | 1428 | WP_032297072.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| HF574_RS29670 (37277) | 37277..37867 | + | 591 | WP_000002778.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| HF574_RS29675 (37854) | 37854..38051 | + | 198 | WP_001324648.1 | conjugal transfer protein TrbD | - |
| HF574_RS29680 (38063) | 38063..38314 | + | 252 | WP_001038341.1 | conjugal transfer protein TrbG | - |
| HF574_RS29685 (38311) | 38311..38826 | + | 516 | WP_062955122.1 | type IV conjugative transfer system lipoprotein TraV | - |
| HF574_RS29690 (38961) | 38961..39182 | + | 222 | WP_001278692.1 | conjugal transfer protein TraR | - |
| HF574_RS29695 (39342) | 39342..41969 | + | 2628 | WP_015059012.1 | type IV secretion system protein TraC | - |
| HF574_RS29700 (41966) | 41966..42352 | + | 387 | WP_015059013.1 | type-F conjugative transfer system protein TrbI | - |
| HF574_RS29705 (42349) | 42349..42981 | + | 633 | WP_001203735.1 | type-F conjugative transfer system protein TraW | - |
| HF574_RS29710 (42978) | 42978..43970 | + | 993 | WP_000830838.1 | conjugal transfer pilus assembly protein TraU | - |
| HF574_RS29715 (43997) | 43997..44305 | + | 309 | WP_000412447.1 | hypothetical protein | - |
| HF574_RS29720 (44368) | 44368..44889 | + | 522 | WP_015059014.1 | hypothetical protein | - |
| HF574_RS29725 (44916) | 44916..45248 | + | 333 | Protein_62 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| HF574_RS29730 (45300) | 45300..46004 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29735 (46488) | 46488..47192 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29740 (47247) | 47247..47561 | + | 315 | Protein_65 | hypothetical protein | - |
| HF574_RS29745 (47642) | 47642..48397 | - | 756 | WP_012372818.1 | 16S rRNA (guanine(1405)-N(7))-methyltransferase | ARG |
| HF574_RS29750 (48567) | 48567..49427 | - | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| HF574_RS29755 (49610) | 49610..50146 | - | 537 | WP_064441864.1 | Tn3 family transposase TnpR_Tn3 | Transposase |
| HF574_RS29760 (50238) | 50238..50426 | + | 189 | WP_000957857.1 | hypothetical protein | - |
| HF574_RS29765 (50436) | 50436..51053 | + | 618 | Protein_70 | IS91 family transposase ISSbo1 | Transposase |
| HF574_RS29770 (51104) | 51104..51808 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29775 (51874) | 51874..52158 | + | 285 | Protein_72 | PAS domain-containing protein | - |
| HF574_RS29780 (52222) | 52222..52926 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29785 (52980) | 52980..53303 | - | 324 | Protein_74 | class II aldolase/adducin family protein | - |
| HF574_RS29790 (53296) | 53296..54548 | - | 1253 | Protein_75 | four-carbon acid sugar kinase family protein | - |
| HF574_RS29795 (54560) | 54560..55462 | - | 903 | WP_002903955.1 | NAD(P)-dependent oxidoreductase | - |
| HF574_RS29800 (55724) | 55724..56485 | + | 762 | WP_002210513.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| HF574_RS29805 (56506) | 56506..57366 | - | 861 | WP_002904004.1 | Beta-lactamase SHV-2 | ARG |
| HF574_RS29810 (57503) | 57503..57571 | + | 69 | Protein_79 | IS6 family transposase | - |
| HF574_RS29815 (57607) | 57607..60093 | - | 2487 | Protein_80 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| HF574_RS29820 (60156) | 60156..60860 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29825 (60915) | 60915..61280 | - | 366 | Protein_82 | type IV conjugative transfer system protein TraE | - |
| HF574_RS29830 (61398) | 61398..62102 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29835 (62228) | 62228..62602 | - | 375 | WP_008324180.1 | hypothetical protein | - |
| HF574_RS29840 (63228) | 63228..63587 | - | 360 | WP_015493069.1 | hypothetical protein | - |
| HF574_RS29845 (63649) | 63649..63972 | - | 324 | WP_008324183.1 | hypothetical protein | - |
| HF574_RS29850 (63969) | 63969..64697 | - | 729 | WP_008324185.1 | plasmid SOS inhibition protein A | - |
| HF574_RS29855 (64694) | 64694..65125 | - | 432 | WP_008324186.1 | conjugation system SOS inhibitor PsiB | - |
| HF574_RS29860 (65168) | 65168..67177 | - | 2010 | Protein_89 | ParB/RepB/Spo0J family partition protein | - |
| HF574_RS29865 (67248) | 67248..67478 | - | 231 | WP_015493071.1 | DUF905 domain-containing protein | - |
| HF574_RS30540 (67763) | 67763..67833 | + | 71 | Protein_91 | hypothetical protein | - |
| HF574_RS29870 (68104) | 68104..68421 | - | 318 | Protein_92 | hypothetical protein | - |
| HF574_RS29875 (68456) | 68456..68710 | - | 255 | WP_015493072.1 | DNA polymerase III subunit theta | - |
| HF574_RS29880 (68903) | 68903..69094 | - | 192 | WP_015493073.1 | hypothetical protein | - |
| HF574_RS29885 (69137) | 69137..69643 | - | 507 | WP_015493074.1 | antirestriction protein ArdA | - |
| HF574_RS29890 (70048) | 70048..70827 | - | 780 | WP_015493075.1 | hypothetical protein | - |
| HF574_RS29895 (70881) | 70881..71300 | - | 420 | WP_015493076.1 | DUF1380 family protein | - |
| HF574_RS29900 (71311) | 71311..71532 | - | 222 | WP_015493077.1 | hypothetical protein | - |
| HF574_RS29905 (71532) | 71532..72209 | - | 678 | WP_002211749.1 | DNA methylase | - |
| HF574_RS29910 (72568) | 72568..73239 | + | 672 | WP_015493079.1 | SOS response-associated peptidase family protein | - |
| HF574_RS29915 (73419) | 73419..73841 | + | 423 | WP_015493080.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| HF574_RS29920 (73841) | 73841..75112 | + | 1272 | WP_015493081.1 | Y-family DNA polymerase | - |
| HF574_RS29925 (75248) | 75248..76219 | - | 972 | WP_016479949.1 | ParB family protein | - |
| HF574_RS29930 (76216) | 76216..77421 | - | 1206 | WP_015493083.1 | Plasmid partition protein A | VF |
| HF574_RS29935 (77784) | 77784..78416 | + | 633 | WP_022652286.1 | Tn3 family transposase TnpR_TnEc1 | Transposase |
| HF574_RS29940 (78470) | 78470..78670 | + | 201 | WP_040219232.1 | hypothetical protein | - |
| HF574_RS29945 (78817) | 78817..79767 | + | 951 | WP_015493085.1 | Recombination-promoting nuclease RpnA | VF |
| HF574_RS29950 (79764) | 79764..80375 | - | 612 | WP_015493086.1 | DUF2913 family protein | - |
| HF574_RS29955 (80372) | 80372..80767 | - | 396 | WP_015493087.1 | hypothetical protein | - |
| HF574_RS29960 (80820) | 80820..81212 | - | 393 | Protein_110 | 3'-5' exonuclease | - |
| HF574_RS29965 (81281) | 81281..82261 | + | 981 | WP_000019473.1 | IS5 family transposase ISKpn26 | Transposase |
| HF574_RS29970 (82243) | 82243..82785 | + | 543 | WP_077273850.1 | restriction endonuclease | - |
| HF574_RS29975 (82913) | 82913..83470 | + | 558 | WP_042934582.1 | hypothetical protein | - |
| HF574_RS29980 (83890) | 83890..84594 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS29985 (84647) | 84647..85933 | - | 1287 | Protein_115 | AAA family ATPase | - |
| HF574_RS29990 (86007) | 86007..86423 | - | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| HF574_RS29995 (86420) | 86420..86650 | - | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin Detail |
| HF574_RS30000 (86607) | 86607..87068 | + | 462 | WP_014343465.1 | hypothetical protein | - |
| HF574_RS30005 (87229) | 87229..88173 | + | 945 | WP_011977810.1 | hypothetical protein | - |
| HF574_RS30010 (88210) | 88210..88602 | + | 393 | WP_011977811.1 | hypothetical protein | - |
| HF574_RS30015 (88660) | 88660..89181 | + | 522 | WP_013214008.1 | hypothetical protein | - |
| HF574_RS30020 (89227) | 89227..89430 | + | 204 | WP_011977813.1 | hypothetical protein | - |
| HF574_RS30025 (89460) | 89460..90464 | + | 1005 | WP_011977814.1 | hypothetical protein | - |
| HF574_RS30030 (90648) | 90648..91427 | + | 780 | WP_013214009.1 | site-specific integrase | - |
| HF574_RS30035 (91473) | 91473..91730 | - | 258 | WP_013214010.1 | hypothetical protein | - |
| HF574_RS30040 (91859) | 91859..91972 | - | 114 | WP_014343462.1 | hypothetical protein | - |
| HF574_RS30045 (92508) | 92508..93374 | + | 867 | WP_004118283.1 | replication initiation protein | - |
| HF574_RS30050 (94484) | 94484..95689 | + | 1206 | WP_011977818.1 | AAA family ATPase | - |
| HF574_RS30055 (95689) | 95689..96663 | + | 975 | WP_011977819.1 | ParB family protein | - |
| HF574_RS30060 (96745) | 96745..98016 | - | 1272 | WP_013214011.1 | Y-family DNA polymerase | - |
| HF574_RS30065 (98016) | 98016..98447 | - | 432 | WP_001568036.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| HF574_RS30070 (98854) | 98854..100341 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| HF574_RS30075 (100590) | 100590..101561 | + | 972 | WP_004152353.1 | plasmid segregation protein ParM | - |
| HF574_RS30080 (101564) | 101564..102235 | + | 672 | WP_013214012.1 | plasmid partitioning/stability family protein | - |
| HF574_RS30085 (102298) | 102298..102528 | + | 231 | WP_001568040.1 | hypothetical protein | - |
| HF574_RS30545 (102724) | 102724..102893 | + | 170 | Protein_136 | hypothetical protein | - |
| HF574_RS30090 (102965) | 102965..103666 | + | 702 | WP_001568041.1 | DNA methylase | - |
| HF574_RS30095 (103666) | 103666..103887 | + | 222 | WP_001568042.1 | hypothetical protein | - |
| HF574_RS30100 (103897) | 103897..104316 | + | 420 | WP_001568043.1 | DUF1380 domain-containing protein | - |
| HF574_RS30105 (104370) | 104370..105137 | + | 768 | WP_013214013.1 | hypothetical protein | - |
| HF574_RS30110 (105818) | 105818..106246 | + | 429 | WP_001568045.1 | antirestriction protein | - |
| HF574_RS30115 (106289) | 106289..106795 | + | 507 | WP_013214014.1 | antirestriction protein ArdA | - |
| HF574_RS30120 (106838) | 106838..107029 | + | 192 | WP_001568047.1 | hypothetical protein | - |
| HF574_RS30125 (107217) | 107217..107471 | + | 255 | WP_011977779.1 | DNA polymerase III subunit theta | - |
| HF574_RS30130 (107506) | 107506..107826 | + | 321 | WP_001568049.1 | hypothetical protein | - |
| HF574_RS30135 (108506) | 108506..108733 | + | 228 | WP_001568050.1 | hypothetical protein | - |
| HF574_RS30140 (108825) | 108825..109055 | + | 231 | WP_001568051.1 | hypothetical protein | - |
| HF574_RS30145 (109107) | 109107..110462 | + | 1356 | WP_014343515.1 | DUF3560 domain-containing protein | - |
| HF574_RS30150 (110510) | 110510..111073 | + | 564 | WP_014343514.1 | methyltransferase | - |
| HF574_RS30155 (111424) | 111424..112128 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS30160 (112134) | 112134..112274 | + | 141 | WP_001044210.1 | hypothetical protein | - |
| HF574_RS30165 (112760) | 112760..113497 | + | 738 | WP_001446887.1 | Tn3 family transposase TnpR_TnEc1 | Transposase |
| HF574_RS30170 (113494) | 113494..113718 | + | 225 | WP_000743213.1 | hypothetical protein | - |
| HF574_RS30550 (113840) | 113840..113926 | + | 87 | Protein_154 | Arm DNA-binding domain-containing protein | - |
| HF574_RS30180 (114198) | 114198..115202 | - | 1005 | WP_000427619.1 | IS110 family transposase IS5075 | Transposase |
| HF574_RS30185 (115281) | 115281..118247 | - | 2967 | WP_042863651.1 | Tn3 family transposase TnpA_ISPa38 | Transposase |
| HF574_RS30190 (118250) | 118250..118315 | - | 66 | Protein_157 | helix-turn-helix domain-containing protein | - |
| HF574_RS30195 (118368) | 118368..119072 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HF574_RS30200 (119097) | 119097..119297 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| HF574_RS30205 (119317) | 119317..120063 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| HF574_RS30210 (120118) | 120118..120678 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| HF574_RS30215 (120810) | 120810..121010 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| HF574_RS30220 (121396) | 121396..121995 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| HF574_RS30225 (122057) | 122057..122389 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (122590) | 122590..122649 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (122590) | 122590..122649 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (122590) | 122590..122649 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (122590) | 122590..122649 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| HF574_RS30230 (122694) | 122694..122843 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin Detail |
| HF574_RS30235 (123127) | 123127..123375 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| HF574_RS30555 (123490) | 123490..123674 | + | 185 | Protein_167 | protein CopA/IncA | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|