MGE detailed information
MGE type: Conjugative plasmid MGE length: 145550 bp
Accession: NZ_CP074121 Location: 1..145550 Organism: Escherichia coli strain EC16 Replicon: plasmid pEC16-NDM-5
Accession: NZ_CP074121 Location: 1..145550 Organism: Escherichia coli strain EC16 Replicon: plasmid pEC16-NDM-5
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KGQ53_RS23065 (1) | 1..978 | + | 978 | WP_000361611.1 | RepB family plasmid replication initiator protein | - |
| KGQ53_RS23070 (1263) | 1263..2003 | - | 741 | WP_001066954.1 | tyrosine-type recombinase/integrase | - |
| KGQ53_RS23075 (2124) | 2124..2312 | - | 189 | WP_014640565.1 | hypothetical protein | - |
| KGQ53_RS23080 (2686) | 2686..3588 | - | 903 | WP_001312822.1 | hypothetical protein | VF |
| KGQ53_RS23085 (3657) | 3657..4764 | - | 1108 | Protein_4 | SDR family oxidoreductase | - |
| KGQ53_RS23090 (5197) | 5197..6150 | - | 954 | WP_000280980.1 | Protease 7 | VF |
| KGQ53_RS23095 (7447) | 7447..7626 | - | 180 | Protein_6 | integrase core domain-containing protein | - |
| KGQ53_RS23100 (7765) | 7765..8504 | + | 740 | Protein_7 | IS3 family transposase IS629 | Transposase |
| KGQ53_RS23105 (9177) | 9177..10685 | + | 1509 | WP_001189123.1 | group II intron reverse transcriptase/maturase | - |
| KGQ53_RS23110 (10769) | 10769..11248 | + | 480 | Protein_9 | IS3 family transposase IS629 | Transposase |
| KGQ53_RS23115 (11396) | 11396..11664 | - | 269 | Protein_10 | IS3 family transposase ISLad1 | Transposase |
| KGQ53_RS23120 (11721) | 11721..12418 | + | 698 | WP_224158172.1 | IS1-like element IS1A family transposase | - |
| KGQ53_RS23125 (12496) | 12496..13885 | - | 1390 | Protein_12 | ISNCY family transposase ISKpn21 | Transposase |
| KGQ53_RS23130 (14195) | 14195..14344 | - | 150 | Protein_13 | IS3 family transposase IS2 | Transposase |
| KGQ53_RS23135 (14522) | 14522..15715 | - | 1194 | WP_000450494.1 | GTP-binding protein | - |
| KGQ53_RS23140 (16938) | 16938..18174 | - | 1237 | Protein_15 | IS3 family transposase IS2 | Transposase |
| KGQ53_RS23145 (18801) | 18801..19094 | + | 294 | WP_000738422.1 | increased serum survival lipoprotein Iss | - |
| KGQ53_RS23150 (19152) | 19152..19351 | - | 200 | Protein_17 | lysis protein | - |
| KGQ53_RS23155 (19905) | 19905..20932 | + | 1028 | Protein_18 | integrase core domain-containing protein | - |
| KGQ53_RS23160 (22243) | 22243..23358 | + | 1116 | WP_001318220.1 | Elloramycin glycosyltransferase ElmGT | VF |
| KGQ53_RS23165 (23498) | 23498..27157 | + | 3660 | WP_001111199.1 | Multidrug efflux ATP-binding/permease protein | VF |
| KGQ53_RS23170 (27261) | 27261..28490 | + | 1230 | WP_000933675.1 | Enterochelin esterase | VF |
| KGQ53_RS23175 (28575) | 28575..29531 | + | 957 | WP_064055648.1 | Ferri-bacillibactin esterase BesA | VF |
| KGQ53_RS23180 (29576) | 29576..31753 | - | 2178 | WP_001222186.1 | Ferric enterobactin receptor | VF |
| KGQ53_RS23185 (31988) | 31988..32685 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| KGQ53_RS23190 (32916) | 32916..34028 | + | 1113 | WP_001615628.1 | IS4 family transposase IS421 | Transposase |
| KGQ53_RS23195 (34652) | 34652..34855 | - | 204 | Protein_26 | hypothetical protein | - |
| KGQ53_RS23200 (35028) | 35028..35195 | + | 168 | Protein_27 | colicin-B | - |
| KGQ53_RS23205 (35213) | 35213..35740 | - | 528 | WP_000203272.1 | colicin B immunity protein | - |
| KGQ53_RS23210 (35984) | 35984..36799 | + | 816 | WP_001312845.1 | lipid II-degrading bacteriocin colicin M | - |
| KGQ53_RS23215 (36849) | 36849..37202 | - | 354 | WP_000864812.1 | colicin M immunity protein | - |
| KGQ53_RS23220 (37380) | 37380..38171 | - | 792 | WP_000016493.1 | site-specific integrase | - |
| KGQ53_RS23225 (38168) | 38168..38857 | - | 690 | WP_000796228.1 | hypothetical protein | - |
| KGQ53_RS23230 (38901) | 38901..39251 | - | 351 | WP_000493379.1 | hypothetical protein | - |
| KGQ53_RS23235 (39783) | 39783..43598 | - | 3816 | WP_249344233.1 | hypothetical protein | - |
| KGQ53_RS23240 (43824) | 43824..44009 | + | 186 | Protein_35 | hypothetical protein | - |
| KGQ53_RS23245 (44027) | 44027..44374 | - | 348 | WP_000142450.1 | DUF6404 family protein | - |
| KGQ53_RS23250 (44676) | 44676..45158 | - | 483 | WP_001311056.1 | hypothetical protein | - |
| KGQ53_RS23255 (45275) | 45275..46123 | - | 849 | WP_023154360.1 | 3'-5' exonuclease | - |
| KGQ53_RS23260 (46169) | 46169..46447 | - | 279 | WP_215260774.1 | type II toxin-antitoxin system toxin YacB | - |
| KGQ53_RS23270 (46557) | 46557..48308 | - | 1752 | Protein_40 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| KGQ53_RS23275 (48312) | 48312..48704 | + | 393 | WP_001351729.1 | isochorismatase family cysteine hydrolase | - |
| KGQ53_RS23280 (48842) | 48842..49726 | + | 885 | WP_000058717.1 | EamA family transporter | - |
| KGQ53_RS23285 (49758) | 49758..50957 | - | 1200 | WP_000804064.1 | Tetracycline resistance protein, class C | ARG |
| KGQ53_RS23290 (51063) | 51063..51713 | + | 651 | WP_038989485.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| KGQ53_RS23295 (51745) | 51745..51990 | - | 246 | WP_041937891.1 | hypothetical protein | - |
| KGQ53_RS23300 (51970) | 51970..52341 | - | 372 | Protein_46 | DUF4158 domain-containing protein | - |
| KGQ53_RS23305 (52345) | 52345..52905 | - | 561 | WP_001161490.1 | recombinase family protein | - |
| KGQ53_RS23310 (53081) | 53081..53431 | - | 351 | WP_000454193.1 | DUF3330 domain-containing protein | - |
| KGQ53_RS23315 (53634) | 53634..54647 | - | 1014 | WP_000845039.1 | IS91 family transposase ISAzo26 | Transposase |
| KGQ53_RS23320 (54792) | 54792..55289 | + | 498 | WP_001083725.1 | Dihydrofolate reductase | ARG |
| KGQ53_RS23325 (55401) | 55401..55691 | + | 291 | WP_001336345.1 | DUF1010 domain-containing protein | - |
| KGQ53_RS23330 (55697) | 55697..56535 | + | 839 | Protein_52 | Streptomycin 3''-adenylyltransferase | ARG |
| KGQ53_RS23335 (56652) | 56652..56999 | + | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| KGQ53_RS23340 (56993) | 56993..57832 | + | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| KGQ53_RS23345 (58237) | 58237..59778 | + | 1542 | WP_000050481.1 | IS91 family transposase ISVsa3 | Transposase |
| KGQ53_RS25930 (60091) | 60091..60465 | + | 375 | Protein_56 | protein-disulfide reductase DsbD family protein | - |
| KGQ53_RS25935 (60565) | 60565..61122 | + | 558 | Protein_57 | twin-arginine translocation (TAT) pathway signal sequence domain protein | - |
| KGQ53_RS23355 (61133) | 61133..61771 | - | 639 | WP_004201168.1 | phosphoribosylanthranilate isomerase | - |
| KGQ53_RS23360 (61776) | 61776..62141 | - | 366 | WP_004201167.1 | bleomycin binding protein Ble-MBL | - |
| KGQ53_RS23365 (62145) | 62145..62957 | - | 813 | WP_023408309.1 | Metallo-beta-lactamase type 2 | ARG |
| KGQ53_RS23370 (63058) | 63058..63351 | - | 294 | Protein_61 | IS30 family transposase ISAba125 | Transposase |
| KGQ53_RS23375 (63516) | 63516..64220 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| KGQ53_RS23380 (64272) | 64272..66302 | + | 2031 | Protein_63 | Tn3 family transposase TnpA_Tn3 | Transposase |
| KGQ53_RS23385 (66355) | 66355..67059 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| KGQ53_RS23390 (67173) | 67173..67949 | + | 777 | WP_212639644.1 | SPBc2 prophage-derived aminoglycoside N(3')-acetyltransferase-like protein YokD | ARG |
| KGQ53_RS23395 (68178) | 68178..69203 | + | 1026 | WP_000742814.1 | Hygromycin-B 4-O-kinase | ARG |
| KGQ53_RS23400 (69278) | 69278..69517 | + | 240 | Protein_67 | AAC(3) family N-acetyltransferase | - |
| KGQ53_RS23405 (69625) | 69625..70362 | - | 738 | WP_212639645.1 | IS6 family transposase ISRle7 | Transposase |
| KGQ53_RS23410 (70402) | 70402..71312 | - | 911 | Protein_69 | Tn3 family transposase TnpA_Tn3 | Transposase |
| KGQ53_RS23415 (71367) | 71367..72071 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| KGQ53_RS23420 (72667) | 72667..74439 | - | 1773 | WP_001262766.1 | DUF262 domain-containing protein | - |
| KGQ53_RS23425 (74724) | 74724..75125 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| KGQ53_RS23430 (75058) | 75058..75315 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| KGQ53_RS23435 (75408) | 75408..76061 | - | 654 | WP_000616800.1 | type II CAAX endopeptidase family protein | - |
| KGQ53_RS23440 (77000) | 77000..77857 | - | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| KGQ53_RS23445 (77850) | 77850..78332 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| KGQ53_RS25940 (78325) | 78325..78372 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| KGQ53_RS25945 (78363) | 78363..78614 | + | 252 | WP_223195197.1 | replication protein RepA | - |
| KGQ53_RS23455 (78631) | 78631..78888 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| KGQ53_RS23460 (79172) | 79172..79321 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin Detail |
| - (79365) | 79365..79426 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| - (79365) | 79365..79426 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| - (79365) | 79365..79426 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| - (79365) | 79365..79426 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| KGQ53_RS23465 (79682) | 79682..79756 | - | 75 | Protein_81 | endonuclease | - |
| KGQ53_RS23470 (80002) | 80002..80214 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| KGQ53_RS23475 (80350) | 80350..80910 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| KGQ53_RS23480 (81013) | 81013..81873 | - | 861 | WP_000704514.1 | putative protein YcjY | VF |
| KGQ53_RS23485 (81932) | 81932..82678 | - | 747 | WP_000205749.1 | conjugal transfer pilus acetylase TraX | - |
| KGQ53_RS23490 (82698) | 82698..87968 | - | 5271 | WP_000986962.1 | Multifunctional conjugation protein TraI | Relaxase |
| KGQ53_RS23495 (88050) | 88050..88277 | + | 228 | WP_000450520.1 | toxin-antitoxin system antitoxin VapB | Antitoxin Detail |
| KGQ53_RS23500 (88277) | 88277..88675 | + | 399 | WP_000911313.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| KGQ53_RS23505 (88684) | 88684..90837 | - | 2154 | WP_000009324.1 | type IV conjugative transfer system coupling protein TraD | - |
| KGQ53_RS23510 (91090) | 91090..91821 | - | 732 | WP_023565183.1 | conjugal transfer complement resistance protein TraT | - |
| KGQ53_RS23515 (91853) | 91853..92350 | - | 498 | WP_000605857.1 | entry exclusion protein | - |
| KGQ53_RS23520 (92366) | 92366..95188 | - | 2823 | WP_001007018.1 | conjugal transfer mating-pair stabilization protein TraG | - |
| KGQ53_RS23525 (95185) | 95185..96558 | - | 1374 | WP_001517790.1 | conjugal transfer pilus assembly protein TraH | - |
| KGQ53_RS23530 (96558) | 96558..96938 | - | 381 | WP_001389370.1 | F-type conjugal transfer protein TrbF | - |
| KGQ53_RS23535 (96925) | 96925..97266 | - | 342 | WP_001443031.1 | P-type conjugative transfer protein TrbJ | - |
| KGQ53_RS23540 (97196) | 97196..97741 | - | 546 | WP_000059851.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| KGQ53_RS23545 (97728) | 97728..98012 | - | 285 | WP_000624109.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| KGQ53_RS23550 (98093) | 98093..98407 | + | 315 | WP_001324103.1 | hypothetical protein | - |
| KGQ53_RS23555 (98409) | 98409..98756 | - | 348 | WP_001287910.1 | conjugal transfer protein TrbA | - |
| KGQ53_RS23560 (98772) | 98772..99515 | - | 744 | WP_001030393.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| KGQ53_RS23565 (99508) | 99508..99765 | - | 258 | WP_000864318.1 | conjugal transfer protein TrbE | - |
| KGQ53_RS23570 (99792) | 99792..101600 | - | 1809 | WP_000821841.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| KGQ53_RS23575 (101597) | 101597..102235 | - | 639 | WP_000777700.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| KGQ53_RS23580 (102244) | 102244..103236 | - | 993 | WP_000830183.1 | conjugal transfer pilus assembly protein TraU | - |
| KGQ53_RS23585 (103233) | 103233..103865 | - | 633 | WP_001203720.1 | type-F conjugative transfer system protein TraW | - |
| KGQ53_RS23590 (103862) | 103862..104248 | - | 387 | WP_000099686.1 | type-F conjugative transfer system protein TrbI | - |
| KGQ53_RS23595 (104245) | 104245..106872 | - | 2628 | WP_001064245.1 | type IV secretion system protein TraC | - |
| KGQ53_RS23600 (107032) | 107032..107253 | - | 222 | WP_001278689.1 | conjugal transfer protein TraR | - |
| KGQ53_RS23605 (107388) | 107388..107903 | - | 516 | WP_000809838.1 | type IV conjugative transfer system lipoprotein TraV | - |
| KGQ53_RS23610 (107900) | 107900..108151 | - | 252 | WP_001038342.1 | conjugal transfer protein TrbG | - |
| KGQ53_RS23615 (108163) | 108163..108360 | - | 198 | WP_001324648.1 | conjugal transfer protein TrbD | - |
| KGQ53_RS23620 (108347) | 108347..108937 | - | 591 | WP_001376242.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| KGQ53_RS23625 (108927) | 108927..110354 | - | 1428 | WP_000146685.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| KGQ53_RS23630 (110354) | 110354..111082 | - | 729 | WP_001230787.1 | type-F conjugative transfer system secretin TraK | - |
| KGQ53_RS23635 (111069) | 111069..111635 | - | 567 | WP_000399792.1 | type IV conjugative transfer system protein TraE | - |
| KGQ53_RS23640 (111657) | 111657..111968 | - | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| KGQ53_RS23645 (111983) | 111983..112348 | - | 366 | WP_000994779.1 | type IV conjugative transfer system pilin TraA | - |
| KGQ53_RS23650 (112381) | 112381..112782 | - | 402 | WP_001369361.1 | conjugal transfer relaxosome DNA-bindin protein TraY | - |
| KGQ53_RS23655 (112875) | 112875..113564 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| KGQ53_RS23660 (113751) | 113751..114134 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| KGQ53_RS23665 (114467) | 114467..115057 | + | 591 | WP_001376243.1 | hypothetical protein | VF |
| KGQ53_RS23670 (115354) | 115354..116175 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| KGQ53_RS23675 (116293) | 116293..116580 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| KGQ53_RS25950 (116605) | 116605..116811 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| KGQ53_RS25955 (116881) | 116881..117053 | + | 173 | Protein_125 | hypothetical protein | - |
| KGQ53_RS25960 (117051) | 117051..117281 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| KGQ53_RS23680 (117501) | 117501..117626 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| KGQ53_RS25965 (117568) | 117568..117717 | - | 150 | Protein_128 | plasmid maintenance protein Mok | - |
| - (117703) | 117703..117927 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| - (117703) | 117703..117927 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| - (117703) | 117703..117927 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| - (117703) | 117703..117927 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| KGQ53_RS23685 (117739) | 117739..117927 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| KGQ53_RS23690 (117896) | 117896..118658 | - | 763 | Protein_130 | plasmid SOS inhibition protein A | - |
| KGQ53_RS23695 (118655) | 118655..119089 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| KGQ53_RS23700 (119144) | 119144..119341 | - | 198 | Protein_132 | hypothetical protein | - |
| KGQ53_RS23705 (119369) | 119369..119602 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| KGQ53_RS23710 (119670) | 119670..120167 | - | 498 | WP_042039995.1 | single-stranded DNA-binding protein | - |
| KGQ53_RS23715 (120317) | 120317..122218 | - | 1902 | WP_000936285.1 | group II intron reverse transcriptase/maturase | - |
| KGQ53_RS23720 (122896) | 122896..123102 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| KGQ53_RS25970 (123172) | 123172..123252 | + | 81 | Protein_137 | hypothetical protein | - |
| KGQ53_RS25975 (123435) | 123435..123604 | - | 170 | Protein_138 | hypothetical protein | - |
| KGQ53_RS23725 (124198) | 124198..125169 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| KGQ53_RS23730 (125169) | 125169..126335 | - | 1167 | WP_001238646.1 | Sporulation initiation inhibitor protein Soj | VF |
| KGQ53_RS23740 (127817) | 127817..130018 | - | 2202 | WP_000973520.1 | Ferric aerobactin receptor | VF |
| KGQ53_RS23745 (130044) | 130044..131377 | - | 1334 | Protein_143 | L-lysine N6-monooxygenase | VF |
| KGQ53_RS23750 (131374) | 131374..133116 | - | 1743 | WP_001015721.1 | Aerobactin synthase | VF |
| KGQ53_RS23755 (133116) | 133116..134063 | - | 948 | WP_000011910.1 | N(6)-hydroxylysine O-acetyltransferase | VF |
| KGQ53_RS23760 (134064) | 134064..135788 | - | 1725 | WP_000602863.1 | N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase | VF |
| KGQ53_RS23765 (135924) | 135924..137117 | + | 1194 | WP_000095526.1 | MFS transporter | - |
| KGQ53_RS23770 (137497) | 137497..137877 | - | 381 | WP_001318207.1 | fluoride efflux transporter CrcB | - |
| KGQ53_RS23775 (138218) | 138218..138631 | - | 414 | Protein_149 | phosphopyruvate hydratase | - |
| KGQ53_RS25980 (138629) | 138629..138886 | + | 258 | Protein_150 | Tn3 family transposase | - |
| KGQ53_RS23780 (139120) | 139120..139977 | - | 858 | WP_000968139.1 | Manganese transport system membrane protein MntB | ARG |
| KGQ53_RS23785 (139974) | 139974..140831 | - | 858 | WP_001101723.1 | Manganese transport system membrane protein MntB | ARG |
| KGQ53_RS23790 (140828) | 140828..141655 | - | 828 | WP_000983710.1 | Iron(3+)-hydroxamate import ATP-binding protein FhuC | VF |
| KGQ53_RS23795 (141655) | 141655..142569 | - | 915 | WP_000949004.1 | Putative metal ABC transporter substrate-binding protein Hpf | VF |
| KGQ53_RS23800 (142925) | 142925..143622 | + | 698 | WP_094096600.1 | IS1-like element IS1A family transposase | - |
| KGQ53_RS23805 (143802) | 143802..144315 | - | 514 | Protein_156 | DUF4113 domain-containing protein | - |
| KGQ53_RS23810 (144376) | 144376..144480 | - | 105 | Protein_157 | AAA family ATPase | - |
| KGQ53_RS23815 (144482) | 144482..144805 | - | 324 | Protein_158 | IS21 family transposase IS21 | Transposase |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|