MGE detailed information
MGE type: Conjugative plasmid MGE length: 134872 bp
Accession: NZ_CP051616 Location: 1..134872 Organism: Escherichia coli O25b:H4-ST131 strain 2017_APHA Replicon: plasmid pAPHA_2017_1
Accession: NZ_CP051616 Location: 1..134872 Organism: Escherichia coli O25b:H4-ST131 strain 2017_APHA Replicon: plasmid pAPHA_2017_1
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHM36_RS24020 () | 1..978 | + | 978 | WP_000361610.1 | RepB family plasmid replication initiator protein | - |
| HHM36_RS24025 () | 1263..2003 | - | 741 | WP_001066941.1 | tyrosine-type recombinase/integrase | - |
| HHM36_RS24030 () | 2124..2312 | - | 189 | WP_001309252.1 | hypothetical protein | - |
| HHM36_RS24035 () | 2679..3848 | + | 1170 | WP_001072358.1 | hypothetical protein | - |
| HHM36_RS24040 () | 4074..4249 | - | 176 | Protein_4 | IS3 family transposase | - |
| HHM36_RS24045 () | 4695..4967 | - | 273 | WP_001322642.1 | Major pilu subunit operon regulatory protein PapB | VF |
| HHM36_RS24050 () | 5492..5928 | - | 437 | Protein_6 | IS3 family transposase IS2 | Transposase |
| HHM36_RS24055 () | 6210..8180 | + | 1971 | WP_001298664.1 | Hemin receptor | VF |
| HHM36_RS24060 () | 8187..8978 | + | 792 | WP_000977394.1 | DUF4198 domain-containing protein | - |
| HHM36_RS24065 () | 9041..9649 | - | 609 | Protein_9 | IS66 family transposase ISEc22 | Transposase |
| HHM36_RS24070 () | 9717..10496 | - | 780 | WP_001323403.1 | IS21 family transposase IS100kyp | Transposase |
| HHM36_RS24075 () | 10496..11518 | - | 1023 | WP_001310017.1 | IS21 family transposase IS100kyp | Transposase |
| HHM36_RS24080 () | 11604..12549 | - | 946 | Protein_12 | IS66 family transposase ISEc8 | Transposase |
| HHM36_RS24085 () | 12598..12945 | - | 348 | WP_000612626.1 | IS66 family transposase ISKpn24 | Transposase |
| HHM36_RS24090 () | 12942..13346 | - | 405 | WP_000839179.1 | IS66 family transposase ISEc22 | Transposase |
| HHM36_RS24095 () | 13375..13758 | - | 384 | Protein_15 | IS3 family transposase IS629 | Transposase |
| HHM36_RS24100 () | 13848..15356 | - | 1509 | WP_001189113.1 | group II intron reverse transcriptase/maturase | - |
| HHM36_RS24105 () | 16029..16768 | - | 740 | Protein_17 | IS3 family transposase IS629 | Transposase |
| HHM36_RS24110 () | 16794..17099 | + | 306 | Protein_18 | IS91 family transposase ISSbo1 | Transposase |
| HHM36_RS24115 () | 17622..18797 | - | 1176 | WP_001020413.1 | putative protein YncE | VF |
| HHM36_RS24120 () | 18866..21127 | - | 2262 | WP_001100763.1 | TonB-dependent receptor | - |
| HHM36_RS24125 () | 21296..22072 | - | 777 | WP_000981091.1 | energy transducer TonB | - |
| HHM36_RS24130 () | 22080..22955 | - | 876 | WP_001224623.1 | ChaN family lipoprotein | - |
| HHM36_RS24135 () | 23287..23973 | - | 687 | Protein_23 | replication initiation protein | - |
| HHM36_RS24140 () | 25424..25759 | - | 336 | WP_001080732.1 | colicin transporter | - |
| HHM36_RS24145 () | 25888..26235 | + | 348 | WP_000142452.1 | hypothetical protein | - |
| HHM36_RS24150 () | 26255..26764 | - | 510 | WP_000194542.1 | hypothetical protein | - |
| HHM36_RS24155 () | 26761..27021 | - | 261 | WP_000371882.1 | hypothetical protein | - |
| HHM36_RS24160 () | 27123..27862 | + | 740 | Protein_28 | IS3 family transposase IS629 | Transposase |
| HHM36_RS24165 () | 28535..28849 | + | 315 | Protein_29 | IS5 family transposase ISKpn26 | Transposase |
| HHM36_RS24170 () | 28850..29023 | + | 174 | Protein_30 | IS5 family transposase ISKpn26 | Transposase |
| HHM36_RS24175 () | 29173..29806 | - | 634 | Protein_31 | histidine-type phosphatase | - |
| HHM36_RS24180 () | 29928..30413 | - | 486 | WP_000874189.1 | hypothetical protein | - |
| HHM36_RS24185 () | 30438..30923 | - | 486 | WP_001267176.1 | TlpA family protein disulfide reductase | - |
| HHM36_RS24190 () | 30910..31605 | - | 696 | WP_000117262.1 | Lipoprotein-releasing system ATP-binding protein LolD | VF |
| HHM36_RS24195 () | 31610..32740 | - | 1131 | WP_000729218.1 | ABC transporter permease | - |
| HHM36_RS24200 () | 32730..34013 | - | 1284 | WP_000964653.1 | ABC transporter permease | - |
| HHM36_RS24205 () | 34016..35395 | - | 1380 | WP_000119836.1 | DUF2318 domain-containing protein | - |
| HHM36_RS24210 () | 35499..36026 | - | 528 | WP_000178050.1 | iron transporter | - |
| HHM36_RS24215 () | 36067..37953 | - | 1887 | WP_000118029.1 | FTR1 family iron permease | - |
| HHM36_RS24220 () | 38300..39115 | - | 816 | WP_012372823.1 | Na(+)-translocating NADH-quinone reductase subunit C | - |
| HHM36_RS24225 () | 39298..39804 | - | 507 | WP_000949452.1 | protein disulfide oxidoreductase | - |
| HHM36_RS24230 () | 39794..39952 | - | 159 | WP_000449408.1 | DsbA family protein | - |
| HHM36_RS24235 () | 40415..41112 | + | 698 | Protein_43 | IS1 family transposase IS1X2 | Transposase |
| HHM36_RS24240 () | 41127..41345 | + | 219 | Protein_44 | IS4 family transposase | - |
| HHM36_RS24245 () | 41395..42099 | - | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| HHM36_RS24250 () | 42158..42907 | - | 750 | Protein_46 | IS91 family transposase ISAzo26 | Transposase |
| HHM36_RS24255 () | 43065..43538 | + | 474 | WP_001389366.1 | Dihydrofolate reductase type 1 | ARG |
| HHM36_RS24260 () | 43669..44457 | + | 789 | WP_000503573.1 | Streptomycin 3''-adenylyltransferase | ARG |
| HHM36_RS24265 () | 44663..45010 | + | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| HHM36_RS24270 () | 45004..45843 | + | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| HHM36_RS24275 () | 45971..46174 | + | 204 | WP_000376616.1 | hypothetical protein | - |
| HHM36_RS24280 () | 46330..47535 | + | 1206 | WP_000184001.1 | chromate efflux transporter | - |
| HHM36_RS24285 () | 47546..47851 | + | 306 | WP_000130000.1 | hypothetical protein | Relaxase |
| HHM36_RS24290 () | 47895..47960 | + | 66 | Protein_54 | EAL domain-containing protein | - |
| HHM36_RS24295 () | 48078..48842 | + | 765 | WP_001389365.1 | IS6 family transposase IS6100 | Transposase |
| HHM36_RS24300 () | 49335..49919 | - | 585 | WP_001137892.1 | TetR family transcriptional regulator | - |
| HHM36_RS24305 () | 49919..51157 | - | 1239 | WP_000004159.1 | MFS transporter | - |
| HHM36_RS24310 () | 51154..52059 | - | 906 | WP_000219391.1 | hypothetical protein | ARG |
| HHM36_RS24315 () | 52181..52885 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HHM36_RS24320 () | 52946..53122 | + | 177 | Protein_60 | replication protein C | - |
| HHM36_RS24325 () | 53430..54245 | + | 816 | WP_001043260.1 | Dihydropteroate synthase | ARG |
| HHM36_RS24330 () | 54306..55109 | + | 804 | WP_001082319.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| HHM36_RS24335 () | 55109..55945 | + | 837 | WP_000480972.1 | hypothetical protein | ARG |
| HHM36_RS24340 () | 55999..56235 | + | 237 | WP_042005022.1 | hypothetical protein | - |
| HHM36_RS24345 () | 56267..56893 | - | 627 | WP_031606906.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| HHM36_RS24350 () | 56999..58198 | + | 1200 | WP_000804064.1 | Tetracycline resistance protein, class C | ARG |
| HHM36_RS24355 () | 58230..58562 | - | 333 | Protein_67 | EamA family transporter | - |
| HHM36_RS24360 () | 58615..59319 | - | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| HHM36_RS24365 () | 59379..59741 | - | 363 | Protein_69 | IS5 family transposase IS903B | Transposase |
| HHM36_RS24370 () | 59776..60651 | - | 876 | WP_032277257.1 | Beta-lactamase CTX-M-97 | ARG |
| HHM36_RS24375 () | 60965..61669 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| HHM36_RS24380 () | 61735..62280 | + | 546 | Protein_72 | Tn3 family transposase TnpA_Tn3 | Transposase |
| HHM36_RS24385 () | 62316..62731 | - | 416 | Protein_73 | IS1 family transposase | - |
| HHM36_RS24390 () | 62980..63381 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| HHM36_RS24395 () | 63314..63571 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| HHM36_RS24400 () | 63664..64317 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| HHM36_RS24405 () | 65257..66114 | - | 858 | WP_001617855.1 | incFII family plasmid replication initiator RepA | - |
| HHM36_RS24410 () | 66107..66181 | - | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
| HHM36_RS24415 () | 66418..66672 | - | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| HHM36_RS24420 () | 66969..67103 | - | 135 | WP_023144756.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| - () | 67148..67208 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 67148..67208 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 67148..67208 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 67148..67208 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| HHM36_RS24425 () | 67175..67461 | - | 287 | Protein_81 | DUF2726 domain-containing protein | - |
| HHM36_RS24430 () | 67539..69152 | - | 1614 | WP_000080195.1 | IS66 family transposase ISEc23 | Transposase |
| HHM36_RS24435 () | 69183..69533 | - | 351 | WP_000624722.1 | IS66 family transposase ISEc23 | Transposase |
| HHM36_RS24440 () | 69530..69955 | - | 426 | WP_000422741.1 | IS66 family transposase ISEc23 | Transposase |
| HHM36_RS24445 () | 70514..70726 | - | 213 | WP_013023861.1 | hypothetical protein | - |
| HHM36_RS24450 () | 70857..71417 | - | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
| HHM36_RS24455 () | 71472..72218 | - | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
| HHM36_RS24460 () | 72238..77508 | - | 5271 | WP_001617867.1 | Multifunctional conjugation protein TraI | Relaxase |
| HHM36_RS24465 () | 77508..79697 | - | 2190 | WP_024946705.1 | type IV conjugative transfer system coupling protein TraD | - |
| HHM36_RS24470 () | 79694..80473 | - | 780 | WP_000199914.1 | hypothetical protein | - |
| HHM36_RS24475 () | 80676..81407 | - | 732 | WP_000850429.1 | complement resistance protein TraT | - |
| HHM36_RS24480 () | 81439..81936 | - | 498 | WP_000605862.1 | entry exclusion protein | - |
| HHM36_RS24485 () | 81955..84774 | - | 2820 | WP_001007062.1 | conjugal transfer mating pair stabilization protein TraG | - |
| HHM36_RS24490 () | 84771..86144 | - | 1374 | WP_000944328.1 | conjugal transfer protein TraH | - |
| HHM36_RS24495 () | 86131..86556 | - | 426 | WP_001348758.1 | F-type conjugal transfer protein TrbF | - |
| HHM36_RS24500 () | 86504..86851 | - | 348 | WP_071571857.1 | P-type conjugative transfer protein TrbJ | - |
| HHM36_RS24505 () | 86781..87326 | - | 546 | WP_000059829.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| HHM36_RS24510 () | 87313..87597 | - | 285 | WP_001617873.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| HHM36_RS24515 () | 87724..88044 | - | 321 | WP_001348757.1 | conjugal transfer protein TrbA | - |
| HHM36_RS24520 () | 88092..88789 | - | 698 | Protein_100 | IS1 family transposase IS1G | Transposase |
| HHM36_RS24525 () | 88863..89174 | - | 312 | WP_000012107.1 | type IV conjugative transfer system protein TraL | - |
| HHM36_RS24530 () | 89179..89541 | - | 363 | WP_000338606.1 | type IV conjugative transfer system pilin TraA | - |
| HHM36_RS24535 () | 89575..89802 | - | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
| HHM36_RS24540 () | 89890..90567 | - | 678 | WP_001348626.1 | PAS domain-containing protein | - |
| HHM36_RS24545 () | 90701..91084 | - | 384 | WP_001151566.1 | relaxosome protein TraM | - |
| HHM36_RS24550 () | 91415..92017 | + | 603 | WP_000243712.1 | hypothetical protein | VF |
| HHM36_RS24555 () | 92314..93135 | - | 822 | WP_001234469.1 | DUF945 domain-containing protein | - |
| HHM36_RS24560 () | 93254..93541 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| HHM36_RS24565 () | 93566..93772 | - | 207 | WP_000275859.1 | hypothetical protein | - |
| HHM36_RS24570 () | 93685..94020 | - | 336 | WP_013023876.1 | hypothetical protein | - |
| HHM36_RS24575 () | 94463..94621 | - | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| - () | 94665..94705 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 94665..94705 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 94665..94705 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 94665..94705 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 96149..96335 | - | 187 | NuclAT_0 | - | - |
| - () | 96149..96335 | - | 187 | NuclAT_0 | - | - |
| - () | 96149..96335 | - | 187 | NuclAT_0 | - | - |
| - () | 96149..96335 | - | 187 | NuclAT_0 | - | - |
| HHM36_RS24585 () | 96347..97066 | - | 720 | WP_001276232.1 | plasmid SOS inhibition protein A | - |
| HHM36_RS24590 () | 97063..97497 | - | 435 | WP_000845940.1 | conjugation system SOS inhibitor PsiB | - |
| HHM36_RS24595 () | 97552..99510 | - | 1959 | WP_000117179.1 | ParB/RepB/Spo0J family partition protein | - |
| HHM36_RS24600 () | 99576..99809 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
| HHM36_RS24605 () | 99872..100411 | - | 540 | WP_000290841.1 | single-stranded DNA-binding protein | - |
| HHM36_RS24610 () | 100556..100891 | - | 336 | WP_013023883.1 | hypothetical protein | - |
| HHM36_RS24615 () | 101054..101314 | - | 261 | WP_024623314.1 | hypothetical protein | - |
| HHM36_RS24620 () | 101340..101903 | - | 564 | WP_001348621.1 | class I SAM-dependent methyltransferase | - |
| HHM36_RS24625 () | 101951..103312 | - | 1362 | WP_000170714.1 | DUF3560 domain-containing protein | - |
| HHM36_RS24630 () | 103364..103594 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| HHM36_RS24635 () | 104629..104820 | - | 192 | WP_001027516.1 | hypothetical protein | - |
| HHM36_RS24640 () | 104817..105239 | - | 423 | WP_000271753.1 | DUF1380 family protein | - |
| HHM36_RS24645 () | 105286..105588 | - | 303 | WP_001671341.1 | antirestriction protein | - |
| HHM36_RS24650 () | 106128..106904 | - | 777 | WP_001753849.1 | hypothetical protein | - |
| HHM36_RS24655 () | 106955..107389 | - | 435 | WP_000274437.1 | DUF1380 family protein | - |
| HHM36_RS24660 () | 107403..107624 | - | 222 | WP_001104873.1 | hypothetical protein | - |
| HHM36_RS24665 () | 107625..108308 | - | 684 | WP_000086185.1 | DNA methylase | - |
| HHM36_RS24670 () | 108385..108689 | - | 305 | Protein_130 | hypothetical protein | - |
| HHM36_RS24675 () | 108693..109595 | - | 903 | WP_001348615.1 | DUF1281 domain-containing protein | - |
| HHM36_RS24680 () | 110462..111433 | - | 972 | WP_000817036.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| HHM36_RS24685 () | 111433..112599 | - | 1167 | WP_000772446.1 | Sporulation initiation inhibitor protein Soj | VF |
| HHM36_RS24690 () | 113187..113942 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| HHM36_RS24695 () | 114716..115522 | - | 807 | WP_000016982.1 | site-specific integrase | - |
| HHM36_RS24700 () | 115523..115828 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| HHM36_RS24705 () | 115830..116048 | - | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| HHM36_RS24710 () | 116756..117751 | + | 996 | WP_000246636.1 | hypothetical protein | - |
| HHM36_RS24715 () | 117755..118687 | + | 933 | WP_000991832.1 | hypothetical protein | - |
| HHM36_RS24720 () | 118824..119521 | - | 698 | Protein_140 | IS1 family transposase IS1G | Transposase |
| HHM36_RS24725 () | 119735..122851 | - | 3117 | WP_001553854.1 | HsdR family type I site-specific deoxyribonuclease | - |
| HHM36_RS24730 () | 122973..124244 | - | 1272 | WP_023142242.1 | restriction endonuclease subunit S | - |
| HHM36_RS24735 () | 124241..125797 | - | 1557 | WP_001617892.1 | type I restriction-modification system subunit M | - |
| HHM36_RS24740 () | 125980..126201 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin Detail |
| HHM36_RS24745 () | 126201..126581 | + | 381 | WP_001216034.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin Detail |
| HHM36_RS24750 () | 126586..126765 | + | 180 | WP_001513661.1 | hypothetical protein | - |
| HHM36_RS24755 () | 126793..127152 | + | 360 | WP_001513660.1 | hypothetical protein | - |
| HHM36_RS24760 () | 127076..127489 | + | 414 | Protein_148 | IS3 family transposase ISLad1 | Transposase |
| HHM36_RS24765 () | 127439..127756 | - | 318 | WP_001513659.1 | hypothetical protein | - |
| HHM36_RS24770 () | 127984..129000 | - | 1017 | WP_012372828.1 | IS5 family transposase IS5D | Transposase |
| HHM36_RS24775 () | 129208..130611 | + | 1404 | WP_001373486.1 | S-methylmethionine permease | - |
| HHM36_RS24780 () | 130598..131530 | + | 933 | WP_000081352.1 | homocysteine S-methyltransferase | - |
| HHM36_RS24785 () | 131639..131968 | - | 330 | Protein_153 | TOBE domain-containing protein | - |
| HHM36_RS24790 () | 131984..132681 | - | 698 | Protein_154 | IS1 family transposase IS1R | Transposase |
| HHM36_RS24795 () | 132739..132987 | + | 249 | Protein_155 | abortive infection family protein | - |
| HHM36_RS24800 () | 133356..134087 | - | 732 | WP_001617898.1 | hypothetical protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|