MGE detailed information

MGE type: Conjugative plasmid        MGE length: 142890 bp
Accession: NZ_CP047406        Location: 1..142890         Organism: Escherichia coli strain MS6193       Replicon: plasmid pMS6193A-NDM


Gene structure


The 5 kb flanking regions of this MGE are displayed.

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6193_RS23780 () 408..626 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin Detail
MS6193_RS23785 () 628..933 + 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin Detail
MS6193_RS23790 () 934..1740 + 807 WP_000016982.1 site-specific integrase -
MS6193_RS23795 () 2514..3269 + 756 WP_174190382.1 replication initiation protein RepE -
MS6193_RS23800 () 3857..5023 + 1167 WP_000772446.1 Sporulation initiation inhibitor protein Soj VF
MS6193_RS23805 () 5023..5994 + 972 WP_000817036.1 ParB/RepB/Spo0J family plasmid partition protein -
MS6193_RS23810 () 6861..7763 + 903 WP_001348615.1 DUF1281 domain-containing protein -
MS6193_RS23815 () 7767..8071 + 305 Protein_7 hypothetical protein -
MS6193_RS23820 () 8148..8831 + 684 WP_000086185.1 DNA methylase -
MS6193_RS23825 () 8832..9053 + 222 WP_001104873.1 hypothetical protein -
MS6193_RS23830 () 9067..9501 + 435 WP_000274437.1 DUF1380 family protein -
MS6193_RS23835 () 9552..10316 + 765 Protein_11 hypothetical protein -
MS6193_RS23840 () 10201..10772 + 572 Protein_12 DUF1472 domain-containing protein -
MS6193_RS23845 () 10868..11170 + 303 WP_001671341.1 antirestriction protein -
MS6193_RS23850 () 11217..11639 + 423 WP_000271753.1 DUF1380 family protein -
MS6193_RS23855 () 11636..11827 + 192 WP_001027516.1 hypothetical protein -
MS6193_RS23860 () 12862..13092 + 231 WP_000218642.1 hypothetical protein -
MS6193_RS23865 () 13144..14505 + 1362 WP_000170714.1 DUF3560 domain-containing protein -
MS6193_RS23870 () 14553..15116 + 564 WP_001348621.1 class I SAM-dependent methyltransferase -
MS6193_RS23875 () 15142..15366 + 225 WP_016238251.1 hypothetical protein -
MS6193_RS23880 () 16467..17036 - 570 WP_089634947.1 hypothetical protein -
MS6193_RS23890 () 18340..19098 + 759 Protein_22 site-specific integrase -
MS6193_RS23895 () 19256..20266 + 1011 WP_000053332.1 substrate-binding domain-containing protein -
MS6193_RS23900 () 20362..22488 + 2127 WP_000253905.1 alpha-galactosidase -
MS6193_RS23905 () 22551..23828 + 1278 WP_001083369.1 MFS transporter -
MS6193_RS23910 () 23828..25258 + 1431 WP_000813680.1 glycoside hydrolase family 32 protein -
MS6193_RS23915 () 25453..26847 + 1395 WP_001037799.1 carbohydrate porin -
MS6193_RS23920 () 27093..27197 - 105 Protein_28 thiosulfate reductase cytochrome B subunit -
MS6193_RS23925 () 27254..27947 + 694 Protein_29 IS1 family transposase IS1A Transposase
MS6193_RS23930 () 27963..28586 + 624 WP_000912556.1 potassium channel family protein -
MS6193_RS23935 () 28671..28922 + 252 Protein_31 iron-containing alcohol dehydrogenase -
MS6193_RS23940 () 29211..29528 - 318 Protein_32 IS110 family transposase -
MS6193_RS23945 () 29683..29788 + 106 Protein_33 plasmid SOS inhibition protein A -
- () 29757..29955 + 199 NuclAT_0 - -
- () 29757..29955 + 199 NuclAT_0 - -
- () 29757..29955 + 199 NuclAT_0 - -
- () 29757..29955 + 199 NuclAT_0 - -
MS6193_RS23950 () 30020..30178 + 159 WP_001302184.1 type I toxin-antitoxin system Hok family toxin Toxin Detail
MS6193_RS23955 () 30846..31052 + 207 WP_000275854.1 hypothetical protein -
MS6193_RS23960 () 31077..31364 + 288 WP_000107242.1 hypothetical protein -
MS6193_RS23965 () 31483..32304 + 822 WP_001234465.1 DUF945 domain-containing protein -
MS6193_RS23970 () 32600..33172 - 573 WP_000949660.1 hypothetical protein VF
MS6193_RS23975 () 33542..33925 + 384 WP_001063020.1 relaxosome protein TraM -
MS6193_RS23980 () 34116..34763 + 648 WP_000332520.1 conjugal transfer transcriptional regulator TraJ -
MS6193_RS23985 () 34899..35114 + 216 WP_001352842.1 conjugal transfer relaxosome protein TraY -
MS6193_RS23990 () 35157..35522 + 366 WP_000340282.1 type IV conjugative transfer system pilin TraA -
MS6193_RS23995 () 35537..35848 + 312 WP_000012106.1 type IV conjugative transfer system protein TraL -
MS6193_RS24000 () 35870..36436 + 567 WP_000399790.1 type IV conjugative transfer system protein TraE -
MS6193_RS24005 () 36423..36596 + 174 Protein_45 traK family protein -
MS6193_RS24010 () 36597..37007 + 411 Protein_46 conjugal transfer protein TraP -
MS6193_RS24015 () 36994..37131 + 138 WP_001553834.1 conjugal transfer protein TrbD -
MS6193_RS24020 () 37153..37314 + 162 WP_000741714.1 conjugal transfer protein TrbD -
MS6193_RS24025 () 37307..37558 + 252 WP_001038342.1 conjugal transfer protein TrbG -
MS6193_RS24030 () 37555..38070 + 516 WP_000809832.1 type IV conjugative transfer system lipoprotein TraV -
MS6193_RS24035 () 38205..38426 + 222 WP_001278692.1 conjugal transfer protein TraR -
MS6193_RS24040 () 38586..41213 + 2628 WP_001064264.1 type IV secretion system protein TraC -
MS6193_RS24045 () 41210..41596 + 387 WP_000099690.1 type-F conjugative transfer system protein TrbI -
MS6193_RS24050 () 41593..42225 + 633 WP_001203720.1 type-F conjugative transfer system protein TraW -
MS6193_RS24055 () 42222..42380 + 159 Protein_55 Multifunctional conjugation protein TraI Relaxase
MS6193_RS24060 () 43540..44286 + 747 WP_000205701.1 conjugal transfer pilus acetylase TraX -
MS6193_RS24065 () 44341..44901 + 561 WP_000139363.1 fertility inhibition protein FinO -
MS6193_RS24070 () 45034..45246 + 213 WP_005012601.1 hypothetical protein -
MS6193_RS24075 () 45547..46249 - 703 Protein_59 IS1 family transposase IS1S Transposase
MS6193_RS24080 () 46350..46532 + 183 WP_000968309.1 hypothetical protein -
- () 46671..46732 - 62 NuclAT_1 - -
- () 46671..46732 - 62 NuclAT_1 - -
- () 46671..46732 - 62 NuclAT_1 - -
- () 46671..46732 - 62 NuclAT_1 - -
MS6193_RS24085 () 46719..46925 + 207 WP_015387399.1 type I toxin-antitoxin system Hok family toxin -
MS6193_RS24090 () 47209..47466 + 258 WP_000083833.1 replication regulatory protein RepA -
MS6193_RS24095 () 47702..47776 + 75 WP_001365705.1 RepA leader peptide Tap -
MS6193_RS24100 () 47769..48215 + 447 Protein_64 incFII family plasmid replication initiator RepA -
MS6193_RS24105 () 48161..48643 - 483 Protein_65 VENN motif pre-toxin domain-containing protein -
MS6193_RS24110 () 49536..50756 + 1221 WP_000410951.1 arginine deiminase -
MS6193_RS24115 () 50767..51678 + 912 WP_000440183.1 carbamate kinase -
MS6193_RS24120 () 51763..52767 + 1005 WP_000154544.1 Ornithine carbamoyltransferase VF
MS6193_RS24125 () 52815..54218 + 1404 WP_000514417.1 YfcC family protein -
MS6193_RS24130 () 54299..54778 + 480 WP_001496175.1 ArgR family transcriptional regulator -
MS6193_RS24135 () 54842..55183 - 342 Protein_71 transposase -
MS6193_RS24140 () 55135..55356 - 222 WP_000080217.1 hypothetical protein -
MS6193_RS24145 () 55387..55737 - 351 WP_000624725.1 IS66 family insertion sequence element accessory protein TnpB -
MS6193_RS24150 () 55734..56096 - 363 WP_059330006.1 IS66 family transposase ISEc23 Transposase
MS6193_RS24155 () 56205..56898 - 694 Protein_75 IS1 family transposase IS1A Transposase
MS6193_RS24160 () 56931..57509 + 579 WP_032147503.1 DUF2726 domain-containing protein -
MS6193_RS24165 () 57922..58275 - 354 WP_000005489.1 hypothetical protein -
MS6193_RS24170 () 58747..59769 - 1023 WP_000156883.1 IS110 family transposase ISSm1 Transposase
MS6193_RS24175 () 60174..60431 + 258 WP_000083821.1 replication regulatory protein RepA -
MS6193_RS24180 () 60667..60741 + 75 WP_001365705.1 RepA leader peptide Tap -
MS6193_RS24185 () 60734..61591 + 858 WP_000130948.1 incFII family plasmid replication initiator RepA -
MS6193_RS24190 () 62530..63183 + 654 WP_000616807.1 CPBP family intramembrane metalloprotease -
MS6193_RS24195 () 63276..63533 + 258 WP_000557619.1 type II toxin-antitoxin system antitoxin PemI -
MS6193_RS24200 () 63466..63867 + 402 WP_001398199.1 type II toxin-antitoxin system toxin endoribonuclease PemK -
MS6193_RS24205 () 64004..65089 - 1086 Protein_85 Tn3 family transposase TnpA_Tn5403 Transposase
MS6193_RS24210 () 65148..65852 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase
MS6193_RS24215 () 65996..66550 + 555 WP_063840321.1 Aminoglycoside N(6')-acetyltransferase type 1 ARG
MS6193_RS24220 () 66681..67511 + 831 WP_001334766.1 Beta-lactamase OXA-1 ARG
MS6193_RS24225 () 67649..68089 + 441 Protein_89 CatB-related O-acetyltransferase -
MS6193_RS24230 () 68143..68847 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
MS6193_RS24235 () 68954..69814 + 861 WP_000557452.1 SPBc2 prophage-derived aminoglycoside N(3')-acetyltransferase-like protein YokD ARG
MS6193_RS24240 () 69827..70369 + 543 WP_002063889.1 AAA family ATPase -
MS6193_RS24245 () 70461..70649 + 189 Protein_93 IS3 family transposase ISKpn11 Transposase
MS6193_RS24250 () 70703..71407 - 705 WP_001067834.1 IS6 family transposase IS26 Transposase
MS6193_RS24255 () 71572..71865 + 294 Protein_95 IS30 family transposase -
MS6193_RS24260 () 71966..72778 + 813 WP_004201164.1 Metallo-beta-lactamase type 2 ARG
MS6193_RS24265 () 72782..73147 + 366 WP_004201167.1 bleomycin binding protein Ble-MBL -
MS6193_RS24270 () 73152..73790 + 639 WP_004201168.1 phosphoribosylanthranilate isomerase -
MS6193_RS24275 () 73801..74832 - 1032 WP_004201169.1 protein-disulfide reductase DsbD N-terminal domain-containing protein -
MS6193_RS24280 () 75145..76686 - 1542 WP_000050481.1 IS91 family transposase ISVsa3 Transposase
MS6193_RS24285 () 77091..77930 - 840 WP_000259031.1 Dihydropteroate synthase ARG
MS6193_RS24290 () 77924..78271 - 348 WP_000679427.1 Multidrug transporter EmrE ARG
MS6193_RS24295 () 78435..79226 - 792 WP_001206356.1 Streptomycin 3''-adenylyltransferase ARG
MS6193_RS24300 () 79232..79522 - 291 WP_001336345.1 DUF1010 domain-containing protein -
MS6193_RS24305 () 79634..80131 - 498 WP_001083725.1 Dihydrofolate reductase ARG
MS6193_RS24310 () 80276..81289 + 1014 WP_000845039.1 IS91 family transposase ISAzo26 Transposase
MS6193_RS24315 () 81492..81842 + 351 WP_000454193.1 DUF3330 domain-containing protein -
MS6193_RS24320 () 81968..82528 + 561 WP_000147567.1 Tn3 family transposase TnpR_TnAs3 Transposase
MS6193_RS24325 () 82531..85497 + 2967 WP_001138064.1 Tn3 family transposase TnpA_TnAs3 Transposase
MS6193_RS24330 () 85564..85941 + 378 WP_000656305.1 GNAT family N-acetyltransferase -
MS6193_RS24335 () 86067..86764 - 698 Protein_111 IS1 family transposase IS1R Transposase
MS6193_RS24340 () 87227..87385 + 159 WP_000449408.1 DsbA family protein -
MS6193_RS24345 () 87375..87881 + 507 WP_000949452.1 protein disulfide oxidoreductase -
MS6193_RS24350 () 88064..88879 + 816 WP_012372823.1 Na(+)-translocating NADH-quinone reductase subunit C -
MS6193_RS24355 () 89226..91112 + 1887 WP_000118029.1 FTR1 family iron permease -
MS6193_RS24360 () 91153..91680 + 528 WP_000178050.1 iron transporter -
MS6193_RS24365 () 91784..93163 + 1380 WP_000119836.1 DUF2318 domain-containing protein -
MS6193_RS24370 () 93166..94449 + 1284 WP_000964653.1 ABC transporter permease -
MS6193_RS24375 () 94439..95569 + 1131 WP_000729220.1 ABC transporter permease -
MS6193_RS24380 () 95574..96269 + 696 WP_000117262.1 Lipoprotein-releasing system ATP-binding protein LolD VF
MS6193_RS24385 () 96256..96741 + 486 WP_001267177.1 TlpA family protein disulfide reductase -
MS6193_RS24390 () 96766..97251 + 486 WP_000874189.1 hypothetical protein -
MS6193_RS24395 () 97373..97903 + 531 Protein_123 histidine-type phosphatase -
MS6193_RS24400 () 97961..98665 - 705 WP_001067834.1 IS6 family transposase IS26 Transposase
MS6193_RS24405 () 98690..99886 + 1197 Protein_125 IS3 family transposase -
MS6193_RS24410 () 99908..100141 + 234 Protein_126 Tn3 family transposase ISPsy39 Transposase
MS6193_RS24415 () 100218..100526 + 309 Protein_127 IS4 family transposase ISEc13 Transposase
MS6193_RS24420 () 100585..101895 - 1311 WP_000476108.1 ABC transporter substrate-binding protein -
MS6193_RS24425 () 101888..102961 - 1074 WP_000950177.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC VF
MS6193_RS24430 () 102967..103791 - 825 WP_000922702.1 phosphodiesterase -
MS6193_RS24435 () 103802..104689 - 888 WP_001271561.1 carbohydrate ABC transporter permease -
MS6193_RS24440 () 104679..105557 - 879 WP_000338039.1 sugar ABC transporter permease -
MS6193_RS24445 () 105688..106128 - 441 Protein_133 zinc-binding dehydrogenase -
MS6193_RS24450 () 106102..106296 + 195 WP_000796505.1 hypothetical protein -
MS6193_RS24455 () 106529..107419 + 891 WP_001077068.1 dihydrodipicolinate synthase family protein -
MS6193_RS24460 () 107444..107824 + 381 WP_000710783.1 Rid family detoxifying hydrolase -
MS6193_RS24465 () 107857..108822 + 966 WP_001022265.1 2-keto-3-deoxygluconate transporter -
MS6193_RS24470 () 108868..109620 - 753 WP_000562172.1 IclR family transcriptional regulator -
MS6193_RS24475 () 110225..110509 + 285 WP_001387467.1 ribbon-helix-helix domain-containing protein Antitoxin Detail
MS6193_RS24480 () 110509..110784 + 276 WP_000421272.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin Detail
MS6193_RS24485 () 110890..111183 + 294 WP_001105060.1 hypothetical protein -
MS6193_RS24490 () 111218..111346 - 129 Protein_142 IS481 family transposase -
MS6193_RS24495 () 111379..112548 - 1170 WP_001072355.1 hypothetical protein -
MS6193_RS24500 () 113041..113348 + 308 Protein_144 type II toxin-antitoxin system ParD family antitoxin -
MS6193_RS24505 () 113691..113873 + 183 WP_042065278.1 hypothetical protein -
MS6193_RS24510 () 113994..114734 + 741 WP_001066942.1 tyrosine-type recombinase/integrase -
MS6193_RS24515 () 115019..115996 - 978 WP_000361612.1 RepB family plasmid replication initiator protein -
MS6193_RS24520 () 116782..117592 + 811 Protein_148 hypothetical protein -
MS6193_RS24525 () 117999..118696 + 698 Protein_149 IS1 family transposase IS1R Transposase
MS6193_RS24530 () 118712..119041 + 330 Protein_150 TOBE domain-containing protein -
MS6193_RS24535 () 119150..120082 - 933 WP_000081352.1 homocysteine S-methyltransferase -
MS6193_RS24540 () 120069..121472 - 1404 WP_001373486.1 S-methylmethionine permease -
MS6193_RS24545 () 121680..122696 + 1017 WP_012372828.1 IS5 family transposase IS5D Transposase
MS6193_RS24550 () 122924..123241 + 318 WP_001513659.1 hypothetical protein -
MS6193_RS24555 () 123191..123604 - 414 Protein_155 IS3 family transposase ISLad1 Transposase
MS6193_RS24560 () 123528..123887 - 360 WP_001513660.1 hypothetical protein -
MS6193_RS24565 () 123915..124094 - 180 WP_001513661.1 hypothetical protein -
MS6193_RS24570 () 124099..124479 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin Detail
MS6193_RS24575 () 124479..124700 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin Detail
MS6193_RS24580 () 124883..126439 + 1557 WP_001553856.1 type I restriction-modification system subunit M -
MS6193_RS24585 () 126436..127719 + 1284 WP_001553855.1 restriction endonuclease subunit S -
MS6193_RS24590 () 127841..130957 + 3117 WP_001553854.1 HsdR family type I site-specific deoxyribonuclease -
MS6193_RS24595 () 131171..131868 + 698 Protein_163 IS1 family transposase IS1G Transposase
MS6193_RS24600 () 132005..132937 - 933 WP_000991832.1 hypothetical protein -
MS6193_RS24605 () 132941..133936 - 996 WP_000246636.1 hypothetical protein -
MS6193_RS24610 () 134401..136539 + 2139 WP_000350635.1 AAA family ATPase -
MS6193_RS24615 () 136701..137117 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin Detail
MS6193_RS24620 () 137114..137344 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin Detail
MS6193_RS24625 () 137651..140770 + 3120 WP_001553851.1 hypothetical protein -
MS6193_RS24630 () 141033..142166 + 1134 WP_000545983.1 DUF3800 domain-containing protein -
MS6193_RS24635 () 142186..142470 + 285 WP_000642771.1 hypothetical protein -
MS6193_RS24640 () 142467..142664 - 198 WP_000215657.1 hypothetical protein -

Similar MGE(s)


Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.

Detail Organism MGE type Related TA Genome accession Coordinates Mash
distance