Detailed information NTG0999529

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: EL099_RS13940
• Genome accession: NZ_LR134271
• Coordinates: 2673781..2675889 (+)
• Length: 702 a.a.
• NCBI ID: WP_126525442.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain NCTC7988
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 2668781..2680889

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL099_RS13915 (NCTC7988_02622)	-	2668845..2669063 (+)	219	WP_000011686.1	sterile alpha motif-like domain-containing protein	-
EL099_RS13920 (NCTC7988_02623)	-	2669453..2669884 (+)	432	WP_000455861.1	CHAP domain-containing protein	-
EL099_RS13925 (NCTC7988_02624)	-	2670025..2671305 (-)	1281	WP_001191005.1	hydroxymethylglutaryl-CoA reductase, degradative	-
EL099_RS13930 (NCTC7988_02625)	-	2671560..2672726 (+)	1167	WP_000151980.1	hydroxymethylglutaryl-CoA synthase	-
EL099_RS13935 (NCTC7988_02626)	-	2672897..2673418 (-)	522	WP_000262603.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
EL099_RS13940 (NCTC7988_02627)	clpE	2673781..2675889 (+)	2109	WP_126525442.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
EL099_RS13945 (NCTC7988_02628)	-	2675956..2676126 (-)	171	WP_000022350.1	FeoB-associated Cys-rich membrane protein	-
EL099_RS13950 (NCTC7988_02629)	feoB	2676139..2678133 (-)	1995	WP_000432916.1	ferrous iron transport protein B	-
EL099_RS13955 (NCTC7988_02630)	-	2678145..2678372 (-)	228	WP_126525443.1	FeoA family protein	-

Sequence

Protein

• Length: 702 a.a.
• Molecular weight: 78008.63 Da
• Isoelectric Point: 4.7368

>NTDB_id=999529 EL099_RS13940 WP_126525442.1 2673781..2675889(+) (clpE) [Staphylococcus aureus strain NCTC7988]
MNNNFFNSDFDSILRRMMQDMQNSNQTSNKKYYINGKEVSPEELAQFTQQGGNHSAEQSAQAFQQAALRQQGQQSGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISI
DISSLEAGTQYRGAFEENIQKLVEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNIMKDAALTRRFNEVLVSEPSAKDTVEILKGIREKFETHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAIDKVATEKRISELEHDKRKAVSAEEYKKADDIQNVIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDANDIERLKNISSRLRSKIIGQDKAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKEA
LIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGTDQEYDDIMQEMKKFFRPEFLNRFNGIVEFLHLDKESLQEIINLLLDDVQVTLDKKGITMNV
SQDAKDWLIEEGYDEDLGARPLRRIVEQQVRDKITDYYLDHTGVKHVDLDIEDNELVIKGKS

Nucleotide

• Length: 2109 bp

>NTDB_id=999529 EL099_RS13940 WP_126525442.1 2673781..2675889(+) (clpE) [Staphylococcus aureus strain NCTC7988]
ATGAATAACAATTTTTTCAATAGTGACTTCGATTCTATTTTGCGAAGAATGATGCAAGACATGCAAAACTCAAATCAGAC
TAGTAACAAGAAATACTATATTAATGGTAAAGAAGTTTCACCGGAAGAATTAGCACAATTTACGCAACAAGGTGGTAATC
ATTCTGCCGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACTAAGACAACAAGGTCAACAAAGTGGCAATGGCAATTAT
CTAGAACAAATTGGTCGTAACTTAACGCAAGAGGCTCGTGATGGATTATTAGATCCAGTCATCGGTCGTGATAAAGAAAT
CCAAGAAACTGCAGAAGTCTTAAGTAGACGCACTAAAAACAATCCTATCCTAGTCGGAGAAGCTGGAGTTGGTAAAACTG
CGATTGTCGAAGGTTTAGCGCAAGCAATCGTTGAAGGGAACGTACCTGCAGCAATCAAAGATAAAGAAATTATATCTATA
GATATTTCATCGCTTGAAGCTGGAACGCAATATCGTGGCGCCTTTGAAGAAAACATCCAAAAGTTAGTTGAAGGCGTTAA
ATCATCACAAAATGCTGTGCTCTTCTTTGACGAAATTCACCAAATCATCGGTTCCGGCGCAACAGGAAGTGATTCCGGTA
GTAAAGGGTTATCTGATATTTTAAAACCAGCATTAAGTCGTGGTGAAATTTCAATTATAGGTGCAACAACTCAAGATGAA
TATCGCAATAATATCATGAAAGACGCTGCATTAACGCGCAGATTTAATGAAGTGCTTGTTAGTGAACCAAGCGCTAAAGA
TACTGTTGAAATTTTAAAAGGTATTCGCGAAAAATTTGAAACACACCATCAAGTCAAATTACCTGATGACGTATTAAAGG
CATGTGTAGACTTATCCATTCAATATATTCCACAACGCTTATTACCTGACAAAGCAATCGATGTATTAGATATTACAGCT
GCACATTTATCTGCACAAAGCCCTGCTATTGATAAAGTCGCGACTGAAAAACGTATTTCTGAATTGGAACATGATAAGCG
TAAAGCTGTAAGTGCTGAAGAATATAAAAAAGCAGATGACATTCAAAATGTAATTAAATCTCTACAAGATAAATTAGAAA
ACAGTAATGGTGAACATACTGCAGTAGCAACGGTGCACGATATTTCTGATACCATTCAACGATTAACTGGTATTCCTGTA
TCTCAAATGGATGCCAATGACATTGAACGTTTAAAAAATATTTCTAGTCGTTTAAGAAGTAAAATCATCGGTCAAGATAA
AGCTGTAGAAATGGTTTCTCGTGCCATTCGTCGTAATCGAGCTGGTTTTGATGATGGCAATCGTCCAATTGGTAGCTTCC
TATTTGTCGGTCCTACTGGTGTTGGTAAAACAGAGCTTGCCAAACAGTTAGCCATTGATTTATTTGGTAATAAAGAGGCA
CTGATTCGACTTGATATGAGTGAATATAGTGATACTACTGCTGTTTCTAAAATGATTGGTACAACTGCTGGTTATGTCGG
TTATGACGATAATTCAAATACATTAACTGAAAAAGTACGACGCAATCCATATTCAGTCATTCTATTTGATGAAATTGAAA
AGGCTAATCCACAAATATTAACATTATTACTACAAGTGATGGATGATGGTAATTTAACAGATGGTCAAGGTAACGTCATC
AACTTTAAAAACACAATCATTATTTGTACGTCAAACGCTGGTTTTGGTAACGGTACAGACCAAGAATACGATGACATTAT
GCAAGAAATGAAAAAATTCTTCCGCCCTGAATTTCTTAACCGCTTCAATGGTATTGTGGAATTCTTACACCTAGATAAAG
AGTCACTACAAGAAATCATTAATTTATTGTTGGATGATGTCCAAGTAACATTAGATAAAAAAGGTATTACGATGAATGTC
TCTCAAGATGCAAAAGATTGGTTAATTGAAGAAGGTTATGATGAAGACTTAGGCGCACGCCCATTAAGACGTATTGTTGA
ACAACAAGTGCGTGACAAAATAACAGATTATTATTTAGATCATACAGGCGTTAAACATGTGGATTTAGATATCGAAGACA
ACGAATTAGTCATCAAAGGTAAATCATGA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (448-603)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

• AAA lid domain (AAA_lid_9) (264-363)

• ATPase family associated with various cellular activities (AAA) (AAA) (123-257)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	47.9	91.595	0.439
clpC	Lactococcus lactis subsp. cremoris KW2	46.361	90.028	0.417
clpE	Streptococcus pneumoniae Rx1	47.326	87.892	0.416
clpE	Streptococcus pneumoniae D39	47.326	87.892	0.416
clpE	Streptococcus pneumoniae R6	47.326	87.892	0.416
clpE	Streptococcus pneumoniae TIGR4	47.326	87.892	0.416
clpC	Bacillus subtilis subsp. subtilis str. 168	43.817	93.305	0.409
clpC	Streptococcus thermophilus LMD-9	44.64	89.031	0.397
clpC	Streptococcus thermophilus LMG 18311	44.48	89.031	0.396
clpC	Streptococcus pneumoniae TIGR4	43.994	87.749	0.386
clpC	Streptococcus pneumoniae Rx1	43.994	87.749	0.386
clpC	Streptococcus pneumoniae D39	43.994	87.749	0.386
clpC	Streptococcus mutans UA159	43.74	87.607	0.383
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.055	88.746	0.373