Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | ABFJ88_RS00290 | Genome accession | NZ_CP155815 |
| Coordinates | 64030..65379 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain CUBIST-17 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 57159..100882 | 64030..65379 | within | 0 |
| SCCmec | 44014..65379 | 64030..65379 | within | 0 |
Gene organization within MGE regions
Location: 44014..100882
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ABFJ88_RS00185 (ABFJ88_00185) | mecA | 44014..46023 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| ABFJ88_RS00190 (ABFJ88_00190) | mecR1 | 46120..47877 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| ABFJ88_RS00195 (ABFJ88_00195) | mecI | 47877..48248 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| ABFJ88_RS00200 (ABFJ88_00200) | psm-mec | 48333..48401 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| ABFJ88_RS00205 (ABFJ88_00205) | - | 48735..49865 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| ABFJ88_RS00210 (ABFJ88_00210) | cstB | 49979..51313 (-) | 1335 | Protein_39 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ABFJ88_RS00215 (ABFJ88_00215) | - | 51346..52410 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| ABFJ88_RS00220 (ABFJ88_00220) | cstR | 52546..52806 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| ABFJ88_RS00225 (ABFJ88_00225) | - | 52806..53444 (+) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| ABFJ88_RS00230 (ABFJ88_00230) | - | 53789..54451 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| ABFJ88_RS00235 | - | 54843..54902 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| ABFJ88_RS00240 (ABFJ88_00235) | erm(A) | 54985..55716 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| ABFJ88_RS00245 (ABFJ88_00240) | - | 55842..56624 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| ABFJ88_RS00250 (ABFJ88_00245) | - | 56775..57152 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| ABFJ88_RS00255 (ABFJ88_00250) | - | 57159..59051 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| ABFJ88_RS00260 (ABFJ88_00255) | - | 59048..60133 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| ABFJ88_RS00265 (ABFJ88_00260) | - | 60252..60569 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| ABFJ88_RS00270 (ABFJ88_00265) | - | 60590..61096 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| ABFJ88_RS00275 (ABFJ88_00270) | - | 61114..61425 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| ABFJ88_RS00280 (ABFJ88_00275) | - | 61512..61862 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ABFJ88_RS00285 (ABFJ88_00280) | ccrB | 62380..64008 (-) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| ABFJ88_RS00290 (ABFJ88_00285) | ccrA | 64030..65379 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| ABFJ88_RS00295 (ABFJ88_00290) | cch1 | 65613..67406 (-) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| ABFJ88_RS00300 (ABFJ88_00295) | ssb | 67406..67702 (-) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| ABFJ88_RS00305 (ABFJ88_00300) | - | 67895..68941 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| ABFJ88_RS00310 (ABFJ88_00305) | - | 69192..70333 (-) | 1142 | Protein_59 | IS3-like element ISSau4 family transposase | - |
| ABFJ88_RS00315 (ABFJ88_00310) | - | 70844..71777 (-) | 934 | Protein_60 | YfcC family protein | - |
| ABFJ88_RS00320 (ABFJ88_00315) | - | 72490..73185 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| ABFJ88_RS00325 (ABFJ88_00320) | - | 73160..75829 (-) | 2670 | WP_000446429.1 | sensor histidine kinase KdpD | - |
| ABFJ88_RS00330 (ABFJ88_00325) | kdpF | 75996..76076 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| ABFJ88_RS00335 (ABFJ88_00330) | kdpA | 76097..77773 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| ABFJ88_RS00340 (ABFJ88_00335) | - | 77792..79813 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| ABFJ88_RS00345 (ABFJ88_00340) | - | 79829..80386 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| ABFJ88_RS00350 (ABFJ88_00345) | - | 80931..81800 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| ABFJ88_RS00355 (ABFJ88_00350) | - | 81810..82706 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| ABFJ88_RS00360 (ABFJ88_00355) | - | 83825..84451 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| ABFJ88_RS00365 (ABFJ88_00360) | - | 84566..86074 (+) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| ABFJ88_RS00370 (ABFJ88_00365) | - | 86324..86458 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| ABFJ88_RS00375 (ABFJ88_00370) | - | 86422..86514 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| ABFJ88_RS00380 (ABFJ88_00375) | - | 86661..88406 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| ABFJ88_RS00385 (ABFJ88_00380) | - | 88504..88859 (-) | 356 | Protein_74 | tRNA-dihydrouridine synthase | - |
| ABFJ88_RS00390 (ABFJ88_00385) | - | 89164..89252 (-) | 89 | Protein_75 | hypothetical protein | - |
| ABFJ88_RS00395 (ABFJ88_00390) | - | 89350..90105 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| ABFJ88_RS00400 (ABFJ88_00395) | cstR | 90105..90365 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| ABFJ88_RS00405 (ABFJ88_00400) | cstA | 90502..91566 (+) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| ABFJ88_RS00410 (ABFJ88_00405) | cstB | 91597..92931 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ABFJ88_RS00415 (ABFJ88_00410) | sqr | 92950..94143 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| ABFJ88_RS00420 (ABFJ88_00415) | - | 94410..94624 (-) | 215 | Protein_81 | universal stress protein | - |
| ABFJ88_RS00425 (ABFJ88_00420) | - | 94810..95796 (-) | 987 | WP_000662022.1 | tRNA-dihydrouridine synthase | - |
| ABFJ88_RS00430 (ABFJ88_00425) | - | 96105..96308 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| ABFJ88_RS00435 (ABFJ88_00430) | - | 96357..96653 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| ABFJ88_RS00440 (ABFJ88_00435) | - | 96861..97463 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| ABFJ88_RS00445 (ABFJ88_00440) | - | 97730..100882 (+) | 3153 | WP_000080564.1 | ATP-binding protein | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=999440 ABFJ88_RS00290 WP_000815646.1 64030..65379(-) (ccrA) [Staphylococcus aureus strain CUBIST-17]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=999440 ABFJ88_RS00290 WP_000815646.1 64030..65379(-) (ccrA) [Staphylococcus aureus strain CUBIST-17]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |