Detailed information NTG0999268

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABD409_RS06665
• Genome accession: NZ_CP155741
• Coordinates: 1312991..1314028 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 400/03
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1307991..1319028

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD409_RS06645 (ABD409_06620)	-	1308741..1309367 (+)	627	WP_010922497.1	A24 family peptidase	-
ABD409_RS06650 (ABD409_06625)	rlmN	1309449..1310528 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABD409_RS06655 (ABD409_06630)	-	1310532..1311152 (-)	621	WP_002992791.1	YutD family protein	-
ABD409_RS06660 (ABD409_06635)	-	1311600..1312577 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
ABD409_RS06665 (ABD409_06640)	sepM	1312991..1314028 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABD409_RS06670 (ABD409_06645)	coaD	1314015..1314506 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABD409_RS06675 (ABD409_06650)	rsmD	1314496..1315035 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABD409_RS06680 (ABD409_06655)	asnA	1315158..1316150 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ABD409_RS06685 (ABD409_06660)	arcC	1316463..1317413 (-)	951	WP_015057899.1	carbamate kinase	-
ABD409_RS06690 (ABD409_06665)	-	1317433..1318764 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=999268 ABD409_RS06665 WP_010922499.1 1312991..1314028(-) (sepM) [Streptococcus pyogenes strain 400/03]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=999268 ABD409_RS06665 WP_010922499.1 1312991..1314028(-) (sepM) [Streptococcus pyogenes strain 400/03]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693