Detailed information NTG0999209

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABD410_RS06320
• Genome accession: NZ_CP155740
• Coordinates: 1266318..1267355 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1851/03
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1261318..1272355

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD410_RS06300 (ABD410_06270)	-	1262068..1262694 (+)	627	WP_010922497.1	A24 family peptidase	-
ABD410_RS06305 (ABD410_06275)	rlmN	1262776..1263855 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABD410_RS06310 (ABD410_06280)	-	1263859..1264479 (-)	621	WP_002992791.1	YutD family protein	-
ABD410_RS06315 (ABD410_06285)	-	1264927..1265904 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ABD410_RS06320 (ABD410_06290)	sepM	1266318..1267355 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABD410_RS06325 (ABD410_06295)	coaD	1267342..1267833 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABD410_RS06330 (ABD410_06300)	rsmD	1267823..1268362 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABD410_RS06335 (ABD410_06305)	asnA	1268485..1269477 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ABD410_RS06340 (ABD410_06310)	arcC	1269790..1270740 (-)	951	WP_015057899.1	carbamate kinase	-
ABD410_RS06345 (ABD410_06315)	-	1270760..1272091 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=999209 ABD410_RS06320 WP_010922499.1 1266318..1267355(-) (sepM) [Streptococcus pyogenes strain 1851/03]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=999209 ABD410_RS06320 WP_010922499.1 1266318..1267355(-) (sepM) [Streptococcus pyogenes strain 1851/03]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693