Detailed information NTG0999152

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABD426_RS06815
• Genome accession: NZ_CP155739
• Coordinates: 1343281..1344318 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 997/08
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1338281..1349318

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD426_RS06795 (ABD426_06765)	-	1339031..1339657 (+)	627	WP_010922497.1	A24 family peptidase	-
ABD426_RS06800 (ABD426_06770)	rlmN	1339739..1340818 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABD426_RS06805 (ABD426_06775)	-	1340822..1341442 (-)	621	WP_002992791.1	YutD family protein	-
ABD426_RS06810 (ABD426_06780)	-	1341890..1342867 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
ABD426_RS06815 (ABD426_06785)	sepM	1343281..1344318 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABD426_RS06820 (ABD426_06790)	coaD	1344305..1344796 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABD426_RS06825 (ABD426_06795)	rsmD	1344786..1345325 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABD426_RS06830 (ABD426_06800)	asnA	1345448..1346440 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ABD426_RS06835 (ABD426_06805)	arcC	1346753..1347703 (-)	951	WP_015057899.1	carbamate kinase	-
ABD426_RS06840 (ABD426_06810)	-	1347723..1349054 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=999152 ABD426_RS06815 WP_010922499.1 1343281..1344318(-) (sepM) [Streptococcus pyogenes strain 997/08]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=999152 ABD426_RS06815 WP_010922499.1 1343281..1344318(-) (sepM) [Streptococcus pyogenes strain 997/08]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693