Detailed information NTG0999035

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABD412_RS06805
• Genome accession: NZ_CP155737
• Coordinates: 1343313..1344350 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 9606/11
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1338313..1349350

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD412_RS06785 (ABD412_06755)	-	1339063..1339689 (+)	627	WP_010922497.1	A24 family peptidase	-
ABD412_RS06790 (ABD412_06760)	rlmN	1339771..1340850 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABD412_RS06795 (ABD412_06765)	-	1340854..1341474 (-)	621	WP_002992791.1	YutD family protein	-
ABD412_RS06800 (ABD412_06770)	-	1341922..1342899 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
ABD412_RS06805 (ABD412_06775)	sepM	1343313..1344350 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABD412_RS06810 (ABD412_06780)	coaD	1344337..1344828 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABD412_RS06815 (ABD412_06785)	rsmD	1344818..1345357 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABD412_RS06820 (ABD412_06790)	asnA	1345480..1346472 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ABD412_RS06825 (ABD412_06795)	arcC	1346785..1347735 (-)	951	WP_015057899.1	carbamate kinase	-
ABD412_RS06830 (ABD412_06800)	-	1347755..1349086 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=999035 ABD412_RS06805 WP_010922499.1 1343313..1344350(-) (sepM) [Streptococcus pyogenes strain 9606/11]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=999035 ABD412_RS06805 WP_010922499.1 1343313..1344350(-) (sepM) [Streptococcus pyogenes strain 9606/11]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693