Detailed information NTG0998976

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABD407_RS06465
• Genome accession: NZ_CP155736
• Coordinates: 1302119..1303156 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1966/14
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1297119..1308156

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD407_RS06445 (ABD407_06415)	-	1297869..1298495 (+)	627	WP_010922497.1	A24 family peptidase	-
ABD407_RS06450 (ABD407_06420)	rlmN	1298577..1299656 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABD407_RS06455 (ABD407_06425)	-	1299660..1300280 (-)	621	WP_002992791.1	YutD family protein	-
ABD407_RS06460 (ABD407_06430)	-	1300728..1301705 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
ABD407_RS06465 (ABD407_06435)	sepM	1302119..1303156 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABD407_RS06470 (ABD407_06440)	coaD	1303143..1303634 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABD407_RS06475 (ABD407_06445)	rsmD	1303624..1304163 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABD407_RS06480 (ABD407_06450)	asnA	1304286..1305278 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ABD407_RS06485 (ABD407_06455)	arcC	1305591..1306541 (-)	951	WP_015057899.1	carbamate kinase	-
ABD407_RS06490 (ABD407_06460)	-	1306561..1307892 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=998976 ABD407_RS06465 WP_010922499.1 1302119..1303156(-) (sepM) [Streptococcus pyogenes strain 1966/14]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=998976 ABD407_RS06465 WP_010922499.1 1302119..1303156(-) (sepM) [Streptococcus pyogenes strain 1966/14]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693