Detailed information NTG0998919

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABD408_RS06295
• Genome accession: NZ_CP155735
• Coordinates: 1267740..1268777 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 4958/15
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1262740..1273777

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD408_RS06275 (ABD408_06245)	-	1263490..1264116 (+)	627	WP_010922497.1	A24 family peptidase	-
ABD408_RS06280 (ABD408_06250)	rlmN	1264198..1265277 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABD408_RS06285 (ABD408_06255)	-	1265281..1265901 (-)	621	WP_002992791.1	YutD family protein	-
ABD408_RS06290 (ABD408_06260)	-	1266349..1267326 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
ABD408_RS06295 (ABD408_06265)	sepM	1267740..1268777 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABD408_RS06300 (ABD408_06270)	coaD	1268764..1269255 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABD408_RS06305 (ABD408_06275)	rsmD	1269245..1269784 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABD408_RS06310 (ABD408_06280)	asnA	1269907..1270899 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ABD408_RS06315 (ABD408_06285)	arcC	1271212..1272162 (-)	951	WP_015057899.1	carbamate kinase	-
ABD408_RS06320 (ABD408_06290)	-	1272182..1273513 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=998919 ABD408_RS06295 WP_010922499.1 1267740..1268777(-) (sepM) [Streptococcus pyogenes strain 4958/15]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=998919 ABD408_RS06295 WP_010922499.1 1267740..1268777(-) (sepM) [Streptococcus pyogenes strain 4958/15]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693