Detailed information NTG0998862

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ABD411_RS07270
• Genome accession: NZ_CP155734
• Coordinates: 1407731..1408768 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 8373/17
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1402731..1413768

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD411_RS07250 (ABD411_07220)	-	1403481..1404107 (+)	627	WP_010922497.1	A24 family peptidase	-
ABD411_RS07255 (ABD411_07225)	rlmN	1404189..1405268 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ABD411_RS07260 (ABD411_07230)	-	1405272..1405892 (-)	621	WP_002992791.1	YutD family protein	-
ABD411_RS07265 (ABD411_07235)	-	1406340..1407317 (-)	978	WP_023612501.1	LacI family DNA-binding transcriptional regulator	-
ABD411_RS07270 (ABD411_07240)	sepM	1407731..1408768 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ABD411_RS07275 (ABD411_07245)	coaD	1408755..1409246 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ABD411_RS07280 (ABD411_07250)	rsmD	1409236..1409775 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ABD411_RS07285 (ABD411_07255)	asnA	1409898..1410890 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ABD411_RS07290 (ABD411_07260)	arcC	1411203..1412153 (-)	951	WP_369324670.1	carbamate kinase	-
ABD411_RS07295 (ABD411_07265)	-	1412173..1413504 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=998862 ABD411_RS07270 WP_010922499.1 1407731..1408768(-) (sepM) [Streptococcus pyogenes strain 8373/17]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=998862 ABD411_RS07270 WP_010922499.1 1407731..1408768(-) (sepM) [Streptococcus pyogenes strain 8373/17]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693